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To preserve their internal states, living systems often need to fully adapt to disturbances from their environment. Researchers from the @KhammashLab characterise the universal structures for maximally robust biomolecular networks > bit.ly/3DWPsuJ @PNASNews @ETH_en
Credit to my amazing co-author @ankitguptamath and to @ERC_Research for funding. Thanks also to @ETH_en and @ETH_BSSE for providing an excellent research environment and for their continued support.
How do biological networks maintain tight regulation of variables while being subjected to an onslaught of perturbations? We establish simple universal principles for maximal robust adaptation in all biomolecular systems. pnas.org/doi/10.1073/pn… #sysbio #synbio #cybergenetics
Ever needed to grow microbial communities w. different growth rates at fixed population ratios? Here we combine light-controlled antibiotic resistance w/ automated composition sensing & cybergenetics to achieve precise ratiometric control of co-cultures. doi.org/10.1038/s41467…
What are single-cell trajectories trying to tell us? A lot, it turns out. To listen to them we must work in the frequency domain. We've developed methods to connect the underlying network to the frequency spectra of stochastic single-cell trajectories. go.nature.com/3PI0V63
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