AxonalPlasticityLab
@AxonalLab
The Axonal Plasticity Lab is located at the Institute of Anatomy and Cell Biology at JKU Linz, Austria.
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Quite remarkable (understatement of the day!).
Published in @ScienceMagazine: "Direct optical measurement of intramolecular distances with angstrom precision" (Sahl et al.) science.org/doi/10.1126/sc… @mpi_nat @mpi_mr_hd #Optics #Imaging #Microscopy #MINFLUX #Fluorescence
Fantastic opportunity for candidates serious about top notch cell biology in combination with cutting edge imaging!!
PNAS Inaugural Article published: "MINFLUX reveals dynein stepping in live neurons" by J.M. Schleske et al. Open access - read it at pnas.org/doi/abs/10.107… @mpi_mr_hd @mpi_nat @PNASNews #Optics #Imaging #Microscopy #MINFLUX #Fluorescence
My research focuses on the axon initial segment in neurons. I’ll be expanding this work by combining efficient CRISPR genome editing techniques. I’ll be recruiting postdocs, grad students, technicians, and postbacs. If you're interested, please feel free to get in touch!
A dendrite is a dendrite is a dendrite? Dendritic signal integration beyond the “antenna” model link.springer.com/article/10.100…
New publication focusing on one of the coolest cell types ever!
What do you know about Cajal-Retzius cells? Here we show a novel role of this transient population, known for their contribution in cortical layering. nature.com/articles/s4146…
An evolutionarily conserved AnkyrinG-dependent motif clusters axonal K2P K+ channels rupress.org/jcb/article-ab…
And another piece of the puzzle .... great work @VictorMacarron and @ElisaDEste & team.
I have to ask - will this be streamed?? We would all love to hear it! With and without the AIS!
London #neuroscience 🧠 community, you really have to register for 𝗣𝗿𝗼𝗳𝗲𝘀𝘀𝗼𝗿 @GrubbLab's inaugural lecture @dev_neuro @KingsIoPPN. It will clearly be a masterclass in puns - and yes, he will also probably show some pretty cool science⤵️
FAT CONGRATS MATT !!!
Super place for some amazing science, in a great city on top of that! Go check out the Kole group!!
Vacancy alert: we are looking for a postdoc! If you would like to work on the wiring and physiology of the axon (initial segment) in a highly collaborative and supportive environment, supervised by a fantastic mentor, go apply! Please share and retweet🧠 nin.nl/vacancies/post…
Tumor-neuron networks continue to intrigue me ever since we received out first surgery samples from @Miriam__Ratliff in Mannheim. Nice to see you're still going strong! Cheers from Linz!
As part of my PhD thesis @wick_wolfgang lab @DKFZ, @uniklinik_hd, @UniHeidelberg, @HdNeurooncology we investigated the cellular and molecular composition of tumor microtube networks in #Glioblastoma (1/6) The manuscript is hot off the press @NatureComms: nature.com/articles/s4146…
Thorough study with exciting data by our friends across the big pond at @jenkins_paul lab and @NeuroBender . I love the straight forward approach and your attention to detail! Science as it should be😎Congratulations!!
Cajal-Retzius cells in the postnatal hippocampus Read this Research Highlight showcasing work from Ingvild Lynneberg Glærum @Ingvild_glerum, Keagan Dunville @DunvilleKeagan, Giulia Quattrocolo @GQuattrocolo @KISNeuro and colleagues: journals.biologists.com/dev/article/15…
Now published in @BrainStrucFunc !! Our immunohistochemical parcellation of human hippocampal fields DG, CA3, #CA2 & CA1 all along the head, body and tail. Includes stereo coordinates as templates for MRI segmentation. A collab with Carmen Cavada link.springer.com/article/10.100…
See our new preprint 📝! In collaboration with Carmen Cavada, we performed an histochemical segmentation of the human hippocampus along the longitudinal axis using Rph3a, PCP4, Chromogranin A and RGS-14 immunostaining. researchsquare.com/article/rs-282… Much more coming soon!!
Experience shapes chandelier cell function and structure in the visual cortex: tinyurl.com/4vyn875y This publication was a collaborative effort between @kseignet from @ChristiaanLevelt's lab and several colleagues from @PieterRoelfsema 's and Maarten Kole's lab.
Christmas indeed - a new and very interesting study unraveling more of the dynamics at the AIS. Needless to add - beautiful images! Congratulations @christlet and @Biosdfp !
20-30% of scientists may be using commercial antibodies that don’t work as advertised in their protein studies, potentially skewing results. elifesciences.org/digests/91645/….
elifesciences.org
Ineffective antibodies
Twenty to thirty percent of scientists may be using ineffective commercial antibodies in their protein studies suggesting that large-scale independent antibody validation is needed.
So exciting to see this piece of beauty out for real. Congratulations @FreAmeLie and @NoraJamann plus team! Sodium channel endocytosis drives axon initial segment plasticity | Science Advances science.org/doi/10.1126/sc…
Following up recent work highlighting the dynamics of whole-scale axon onset remodeling, this preprint by the Wahle group adds exciting data! Check it out here: biorxiv.org/content/10.110…
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