Dana-Farber Center for Patient Derived Models
@CancerModels
Research center working towards #precisiononcology. Ask us about generation, characterization & applications of patient-derived models (PDX, organoids, cells).
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CPDM's work and our recent Nature Biomedical Engineering paper were featured on dana-farber.org: blog.dana-farber.org/insight/2025/0…
blog.dana-farber.org
Cell Density Speaks Volumes About Cancer Treatment Choices
Published: June 23, 2025Written by: Beth DoughertyAs powerful as modern cancer medicines are, they don’t work for everyone. What if there were a quick test doctors could perform on an individual...
Are you joining us in Copenhagen for the first meeting to unite genomic and functional precision medicine? Find out more eha.fyi/SfPM
Podcast: AI and Organoids Show Promise for Glioblastoma Patients - UHealth physician-news.umiamihealth.org/podcast-ai-and…
Thrilled to share our latest work out today @Nature . A collaborative effort with many great, super smart colleagues, especially @gryfyndor @hovestadt @vangalenlab : nature.com/articles/s4158…
Nice new review of #fpm rdcu.be/ddSjj
Congrats Maria on a fantastic undergrad thesis defense in #glioblastoma functional precision medicine at CPDM. Way to get honors! We were so proud and happy to have you with us & mentors Kin Hoe Chow, Sonam Bhatia, Smitha Yerrum and @KeithLigon5 @NeurosciBU #gpn @BU_Tweets #fpm
Great to see #fpm growing this year to have a whole session at #AACR2023 with exciting prospective trials results and other studies from @CancerModels collaborator @DrTonyLetai as well as Pam Becker and @AlanaWelm @PhilippStaber
Our @TheSFPM president, @DrTonyLetai, starts with a great introduction on functional precision medicine opportunities and challenges #AACR23 #FPMatAACR23
Great meeting of the MassMinds!
President Biden said, "The goal is to cut cancer death rates by at least 50% in the next 25 yrs." This reignited Cancer Moonshot in Boston last September. Register for #SOP23 & explore the opportunities & barriers to realizing this ambitious goal. massbio.org/events/listing…
Great to see functional precision medicine now getting BigPharma attention #fpm #precisionmedicine #oncology #cancermodels
Mini-organs attract big pharma go.nature.com/3Ef6jK5 Hans Clevers, head of Pharma Research & Early Development at Roche, discusses the role for organoids in drug discovery and development in this new interview
Join us *THIS WEDNESDAY* March 8th at 11:30 AM EST / 8:30 AM PST for our next seminar featuring @ElementoLab from @WCMEnglanderIPM presenting "From reading genomes to patient avatars - the future of personalized medicine". Link/Info available here: sfpm.io/seminars
sfpm.io
Seminars | SFPM
The SFPM Seminar series is for those interested in the use of assaying technology to further biomarker discovery, drug R&D and personalized healthcare outcomes.
Check our highly collaborative effort with wonderful colleagues and lots of patient-derived models!
Our new paper w/BMS shows CAFs are the source of EMT signal in most cancers --> data from 333 PDX models/11 tumor types from @DanaFarber @CancerModels. Thx Michael Tolstorukov's DFCI I/A team, @Novartis, and David Weinstock for helping CPDM make the models rdcu.be/c6AQl…
Attending #AACR23 in Orlando this year? Save the date and Join us for a fun night of food, drinks, and networking. This is a great opportunity to learn more about the SFPM, meet the board, share ideas and even become a member! RSVP on sfpm.io
On average, it takes more than 10 years and billions of dollars to develop a new drug. Incorporating AI into the drug development pipeline could help create cheaper pharmaceuticals faster. trib.al/nB9fa7X
If an ASO lowers target RNA 50% in bulk brain tissue, is it 50% in all cells or 100% in half? Are cell types all impacted equally? Does CSF reflect neuronal target engagement? We did single-cell seq in ASO-treated mice & NHPs to find out doi.org/10.1101/2023.0… Thread 👇
We think we've found something v.interesting 🧐:IDHwt GBMs can be stratified by treatment response which might inform targeted therapies. Read our study here: tinyurl.com/3ybvwutd Funded by @UKRI_News @BRUKresearch @DiMeN_Diversity @LDShospcharity @OscarsCharity @YorkshireBTC
SFPM Seminar tomorrow: Travera CEO Cliff Reid will present on their novel rapid therapy guidance testing based on single cell mass. #precisionmedicine #oncology sfpm.io/seminars
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