Covalent Modifiers

@CovalentMod

A feed for the blog http://covalentmodifiers.blogspot.com. Discusses the covalent modification of proteins. Available on bsky and mass std don

Ottawa, Ontario

covalentmodifiers.blogspot.com

Joined April 2017

843Posts 5KFollowers 317Following

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Covalent Modifiers

@CovalentMod

Aug 8

FYI, the code that tweets out notices of new posts stopped working some months ago. If you'd like to continuing following this content, subscribe to the blog feed directly or follow us on bsky.

Zongertinib (BI 1810631), an Irreversible HER2 TKI, Spares EGFR Signaling and Improves Therapeutic Response in Preclinical Models and Patients with HER2-Driven Cancers covalentmodifiers.blogspot.com/2025/05/zonger…

Covalent Modifiers

@CovalentMod

May 25

Design, synthesis and biological evaluation of the activity-based probes for FGFR covalent inhibitor covalentmodifiers.blogspot.com/2025/05/design…

Covalent Modifiers

@CovalentMod

May 24

Discovery of a Novel Serine-Targeting Covalent Inhibitor against HCES2A for Treating Drug-induced Diarrhea and Ulcerative Colitis covalentmodifiers.blogspot.com/2025/05/discov…

Covalent Modifiers

@CovalentMod

May 18

Chimeric deubiquitinase engineering reveals structural basis for specific inhibition of the mitophagy regulator USP30 covalentmodifiers.blogspot.com/2025/05/chimer…

Covalent Modifiers

@CovalentMod

May 16

Blocking C-terminal processing of KRAS4b via a direct covalent attack on the CaaX-box cysteine covalentmodifiers.blogspot.com/2025/05/blocki…

Covalent Modifiers

@CovalentMod

May 8

Discovery of Carbodiimide Warheads to Selectively and Covalently Target Aspartic Acid in KRASG12D covalentmodifiers.blogspot.com/2025/05/discov…

Covalent Modifiers

@CovalentMod

May 8

Residue-Selective Inhibitors Discovery via Covalent DNA-Encoded Chemical Libraries with Diverse Warheads covalentmodifiers.blogspot.com/2025/05/residu…

Covalent Modifiers

@CovalentMod

May 2

Glecirasib, a potent and selective covalent KRAS G12C inhibitor exhibiting synergism 2 with cetuximab or SHP2 inhibitor JAB-3312 covalentmodifiers.blogspot.com/2025/05/glecir…

Covalent Modifiers reposted

Ingo Hartung

@HartungIngo

Apr 27

Clinical update for zoldonrasib - Ras(on)G12D selective covalent inhibitor - dosed at 1200 mg qd po (MTD previously not reached). Generally well tolerated, 89% disease control rate for NSCLC patients, two promising case studies shared, but still very early days. #AACR25 @AACR

HartungIngo's tweet image. Clinical update for zoldonrasib - Ras(on)G12D selective covalent inhibitor - dosed at 1200 mg qd po (MTD previously not reached). Generally well tolerated, 89% disease control rate for NSCLC patients, two promising case studies shared, but still very early days. #AACR25 @AACR

Covalent Modifiers

@CovalentMod

Apr 27

Discovery and Optimization of a Covalent AKR1C3 Inhibitor covalentmodifiers.blogspot.com/2025/04/discov…

Covalent Modifiers

@CovalentMod

Apr 27

DCAF16-Based Covalent Degradative Handles for the Modular Design of Degraders covalentmodifiers.blogspot.com/2025/04/dcaf16…

Covalent Modifiers

@CovalentMod

Apr 26

Proteomic Ligandability Maps of Phosphorus(V) Stereoprobes Identify Covalent TLCD1 Inhibitors covalentmodifiers.blogspot.com/2025/04/proteo…

Covalent Modifiers

@CovalentMod

Apr 26

Discovery and Optimization of a Covalent AKR1C3 Inhibitor covalentmodifiers.blogspot.com/2025/04/discov…

Covalent Modifiers

@CovalentMod

Apr 24

Discovery of RNA-Reactive Small Molecules Guides Design of Electrophilic Modules for RNA-Specific Covalent Binders covalentmodifiers.blogspot.com/2025/04/discov…

Covalent Modifiers

@CovalentMod

Apr 20

Identification of a phenyl ester covalent inhibitor of caseinolytic protease and analysis of the ClpP1P2 inhibition in mycobacteria covalentmodifiers.blogspot.com/2025/04/identi…

Covalent Modifiers

@CovalentMod

Apr 13

Substrate Trapping in Polyketide Synthase Thioesterase Domains: Structural Basis for Macrolactone Formation covalentmodifiers.blogspot.com/2025/04/substr…

Covalent Modifiers

@CovalentMod

Apr 13

Covalent Modification of Glutamic Acid Inspired by HaloTag Technology covalentmodifiers.blogspot.com/2025/04/covale…

Covalent Modifiers

@CovalentMod

Apr 13

If you'd like to follow Covalent Modifier content on LinkedIn, our "company page" is online linkedin.com/company/covale…

Covalent Modifiers

@CovalentMod

Apr 8

A predictive model for thiol reactivity of N-heteroaryl α-methylene–γ-lactams—a medicinally relevant covalent reactive group covalentmodifiers.blogspot.com/2025/04/a-pred…