Creative Biostructure
@CreBiostructure
We specialize in offering solutions for academia and biotech/pharmaceutical industries in the fields of structural biology and membrane protein technologies.
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Workflow tips (alignment, CTF, WBP/SIRT, STA), fixes for low SNR/missing wedge, and where tools like AreTomo, RELION, Dynamo, Warp, Tomo3D, CryoDRGN-ET fit in—plus AI boosts for picking & denoising. Read: creative-biostructure.com/resource-cryo-… #CryoET #CryoEM #Tomography #StructuralBiology
The authors use time-resolved cryo-EM to reveal the interactions of the redox-active cofactor TXNL1 with the human 26S proteasome and detect ATPase motor states that indicate burst-like mechanisms for hand-over-hand substrate translocation. nature.com/articles/s4159…
Thanksgiving deal: 15% OFF all Creative Biostructure services (Nov 10-30, 2025). Protein expression → XRD, Cryo-EM, NMR, MicroED, CD/FTIR & more. Redeem: add THANKS15 in the “Project Description” when you inquire/order. Start here 👉 creative-biostructure.com/thanksgiving-s… #StructuralBiology
FTIR spectroscopy = molecular fingerprinting. Reveal protein folding, ligand binding & membrane dynamics through infrared vibrations. Read how FTIR works + key applications in drug discovery & structural biology. creative-biostructure.com/guide-to-fouri… #FTIR #ProteinStructure #StructuralBiology
The authors use cryo-EM to obtain structures that reveal how DNMT3A2 and DNMT3L cooperate to read histone signals and bind chromatin, illustrating a mechanism that controls DNA methylation and shapes epigenetic regulation. nature.com/articles/s4159…
Single-Crystal XRD = Atomic Precision. Learn how XRD works + real case studies in drug design & materials science. 🔗 creative-biostructure.com/resource-singl… #XRayDiffraction #Crystallography #StructuralBiology #DrugDiscovery #CreativeBiostructure
Latency is conferred by a homodimeric prodomain with a previously undefined domain architecture. Here the authors define the architecture of the prodomain as domain-swapped providing structural insights into the mechanism of activation of L-TGF-β. nature.com/articles/s4146…
CD for proteins—quick, sensitive, solution-state: • Far-UV: secondary structure, folding, stability (Tm) • Near-UV: tertiary packing (Trp/Tyr/Phe, disulfides), ligand effect Setup tips + deconvolution & kinetics inside our guide. creative-biostructure.com/resource-circu… #ProteinCharacterization
Cholesterol plays a key role in membrane biology. Here, authors employ evolutionary molecular dynamics simulations to explore interactions driven by linear protein sequences, challenging the predictive power of traditional cholesterol-binding motifs. nature.com/articles/s4146…
Far-UV vs Near-UV CD—know when to use each: • Far-UV (190–250 nm): secondary structure, folding, stability (Tm) • Near-UV (250–320 nm): tertiary environment (Trp/Tyr/Phe, disulfides), ligand effects 🔗 creative-biostructure.com/resource-far-u… #CircularDichroism #ProteinCharacterization
ERDRP-0519, a potent nonnucleoside Morbillivirus inhibitor, was visualized bound to measles RNA polymerase by cryo-EM, revealing a unique RdRp palm pocket and clarifying resistance mechanisms for next-generation antivirals. nature.com/articles/s4146…
nature.com
Structural basis of measles virus polymerase inhibition by nonnucleoside inhibitor ERDRP-0519
Nature Communications - ERDRP-0519 is a potent nonnucleoside inhibitor of Morbilliviruses. In this work, authors solve cryo-EM structures that reveal ERDRP-0519 bound to measles RNA polymerase in a...
Protein X-ray crystallography challenges, solved: • Crystals: improve purity, use fusion tags or microseeding • Phasing: apply SAD/MAD or AlphaFold-based MR • Radiation: limit dose, use SSX/XFEL or cryo methods 🔗 creative-biostructure.com/resource-commo… #StructuralBiology #DrugDiscovery
Zika virus protease NS2B-NS3 is key to viral replication. Using crystallographic fragment screening and deep mutational scanning, researchers reveal binding sites for resistance-resilient antiviral inhibitors. nature.com/articles/s4146…
From construct design → host selection → Affinity/IEX/SEC → QC (DLS/CD/DSF/MS), great crystals start upstream. Our new guide shares solubility/stability fixes and scale-up tips to deliver crystal-ready protein—fast. 🔗 creative-biostructure.com/resource-optim… #StructuralBiology #DrugDiscovery
This study reveals how human SUMO E1 recruits its E2 partner UBC9 and transfers SUMO1 through large structural changes, uncovering key mechanisms that ensure specificity and fidelity in SUMOylation, an essential protein modification pathway. nature.com/articles/s4159…
SCXRD vs MicroED—what’s best for your crystal? • SCXRD: sub-Å precision, mature X-ray workflows • MicroED: nano/micro-crystals, minimal material, faster results 🔗 creative-biostructure.com/resource-scxrd… #Crystallography #SCXRD #MicroED #StructuralBiology #DrugDiscovery #MaterialsScience
Convergent evolution of proteins has been extensively studied at the levels of amino acid residues and local domain structures. Here, authors unveil a global structural convergence of protein complexes among fusion protein families in nature. nature.com/articles/s4146…
From snapshots to systems thinking: Integrative Structural Biology merges Cryo-EM/ET, X-ray, NMR, MS, SAXS, and MD/AI to deliver more accurate, dynamic models for #DrugDiscovery. Dive into workflows, case studies, and CRO use-cases in our new article. 🔗 creative-biostructure.com/resource-integ…
Comparison between structures of human, mouse and rat P2X7 receptors define ortholog-specific pharmacology and facilitated structure-based drug design of UB-MBX-46, an antagonist that selectively inhibits the human P2X7 receptor with sub-nanomolar potency. nature.com/articles/s4146…
MicroED vs. Cryo-EM SPA: • MicroED → atomic detail from tiny crystals • SPA → near-atomic maps of large complexes Full comparison: creative-biostructure.com/resource-micro… #MicroED #CryoEM #StructuralBiology
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