Daniel Kantor
@DrKantor
Please visit: https://twitter.com/KantorNeurology http://facebook.com/KantorNeurology
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Thank you @MSDoc_Freedman @uOttawaMed @uOttawa @OttawaHospital for your service to ACTRIMS ®. Congratulations Emmanuelle Waubant @UCSF for taking over as President. @ACTRIMS
Great job by the scientific organizing committee: Veronique Miron @UofTNeurology @UofT, @DanOntaneda @ClevelandClinic, Tiffany Braley @UMich, Jeffrey Cohen @ClevelandClinic, @AnneCross1 @WashUNephrology @WashU, @Duttalab2017 @ClevelandClinic, @AKunchok @ClevelandClinic, ...
... Jiwon Oh @UofToronto, Manu Rangachari @universitelaval, Dalia Rotstein @uoftoronto, and @DrBenSegalNeuro @OhioStateNeuro @OhioState Thank you #ACTRIMSFORUM 2025!
Late-breaking #ACTRIMSFORUM talk by Alexandra Scharf @CWRUSOM @cwru @ClevelandClinic on Application of 2024 McDonald Criteria to Individuals with Atypical and Radiological Only Presentations in a Multicenter Diagnostic Biomarker Study. @ACTRIMS
Using new criteria, 32% of participants with radiologically-only presentation & 28% with atypical onset meet the new criteria. CVS (central vein sign) is among the most useful para-clinical tool to confirm #MS in these populations.
But what do YOU think about these new (complicated) 2024 McDonald criteria? @SKriegerMD @IcahnMountSinai
Late-breaking #ACTRIMSFORUM: @MDKornberg @JohnsHopkins on A Six-month Ketogenic Diet Alters the Immune and Metabolic Landscape In Multiple Sclerosis. @ACTRIMS @ECTRIMS @lactrims_org
• Decreased B cell activation • Dietary effects on lymphocytes may be downstream of myeloid-lymphoid cross-talk • Immunologic changes are associated with metabolic adaptations across immune
Dr Myla Goldman @VCUnews @VCU answered audience member’s question that adherence to the diet was verified by daily urine dipsticks looking for ketones. #Neurtrition
Late-breaking #ACTRIMSFORUM chaired by @DanOntaneda @ClevelandClinic & Wee Young @UCalgary. Jiwon Oh @utoronto on Paramagnetic Rim Lesions as a Prognostic and Predictive Biomarker in the Tolebrutinib Phase 3 Trials for Disability Outcomes.
The impact of @sanofi @sanofius #tolebrutinib vs. hashtag#Aubagio #terifkunomide on 6-month CDW (confirmed disability worsening) was more evident in participants with PRLs (paramagnetic rim lesions) at baseline in #GEMINI.
Same for CDP (confirmed disability progression) for tolebrutinib vs. placebo in #HERCULES. @ACTRIMS @ECTRIMS
#ACTRIMSFORUM: Letizia Leocani @MyUniSR on Functional Assessment of Disrupted Connectivity. - Utility of MEG (magnetoencephalography) in MS. - Visual oddball ERP - Use of motor evoked potentials in #MS - Is #MS a length-dependent central axonopathy?
- Biogen #Natalizumab #Tysabri restores evoked potential abnormalities in patients with #RRMS. @ACTRIMS @lactrims_org @ictrims2024
#ACTRIMSFORUM: Manuel Comabella Lopez @vallhebron on Astrocyte Mediated Synaptopathy in Multiple Sclerosis. - A highly neuro/inflammatory environment in #MS induces a specific reactive astrocyte state that triggers syncopathy and contributes to neuronal damage. @ACTRIMS
- CHI3L1 is a molecular mediator that links astrocyte to synaptic pathology — represents a potential therapeutic target.
#ACTRIMSFORUM: María Isabel Zuluaga Rodas Multiple Sclerosis Center Medicarte on Connection Between Patients, Patients’ Associations, and Physicians to Collect Real World Data in LATAM. 34% of neurologists in Latin America have no relationship with #MS patient organizations!
Real-world data provide insights that clinical trials alone cannot capture: - Long-term treatment outcomes; - Performance of therapies in diverse, real-life populations; - Measures the impact of comorbidities or regional differences in healthcare access;
- #MS progression is difficult to predict and evaluate in the short term. The relationship between neurologists and people with MS (and their carepartners) in Latin America can learn a lot from the U.S. @MS_Focus @MSassociation @ACTRIMS
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