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T cell friends! CAR T cell aficionados! Here a quiz for you! The TCR have four signalling chains, the CAR uses only one, which one do you think will perform best?
Un autentico honor y un placer volver a Majadahonda. Aquí hice mi tesis doctoral, aquí nació la semilla de la investigación, y ahora volver cierra un emotivo circulo. Gracias a la SICAM por la invitación.
Los Ponentes de las XIII Jornadas Científicas SICAM
Had a great visit to the Kennedy Institute at Oxford yesterday- thanks @AGerardLab for hosting me!
On Monday 18th Nov, Dr Mahima Swamy joins us to talk about "The multiple roles of intraepithelial T lymphocytes in maintaining intestinal homeostasis". Don't miss it! Oxford Talks: talks.ox.ac.uk/talks/id/c51b1…
Vamos, @RafaelNadal! As you get ready to graduate from tennis, I’ve got a few things to share before I maybe get emotional. Let’s start with the obvious: you beat me—a lot. More than I managed to beat you. You challenged me in ways no one else could. On clay, it felt like I…
Excited to read this paper on the changes in the gut upon ageing
Our new paper on the role of Age-related loss of intestinal barrier integrity on T cell ageing is published in Ageing Cell! A massive thank you to@MsMacrophage @GAnderson808 @WvSchaik @ClaudioMauro6 and amazing team @jessicaconway_ doi.org/10.1111/acel.1…
Congratulations Jan! What a year, your are rocking it!
Excited to share that our story on PGE2-mediated control of NK cell metastasis surveillance in lung tissue is now published in @CellReports 🤝 Thanks to the many great colleagues who helped conduct this study! 👏Congratulations to first author @AMPedde! cell.com/cell-reports/f…
Interesting and important.
1/10 PREPRINT MONDAY at the SchubertLab Benchmarking TCR-Epitope Predictors with ePytope-TCR (doi.org/10.1101/2024.1…) Short-Summary: - 18 pre-trained public methods - evaluated on 2 benchmarking datasets - for repertoire annotation & cross-reactivity prediction
Wow, thanks Chenqi for sharing, as always, interesting, insightful and fun to read!
We are happy to publish a perspective @NatRevImmunol, focusing on a charge-based signaling motif BRS. Being widely present in immunoreceptors and other membrane proteins, BRS can regulate many aspects of immune responses. nature.com/articles/s4157…
nature.com
Charge-based immunoreceptor signalling in health and disease
Nature Reviews Immunology - The basic-residue-rich sequence (BRS) is a common motif located in the cytoplasmic tail of most immunoreceptors. This Perspective highlights the mechanisms of BRS...
We are happy to publish a perspective @NatRevImmunol, focusing on a charge-based signaling motif BRS. Being widely present in immunoreceptors and other membrane proteins, BRS can regulate many aspects of immune responses. nature.com/articles/s4157…
nature.com
Charge-based immunoreceptor signalling in health and disease
Nature Reviews Immunology - The basic-residue-rich sequence (BRS) is a common motif located in the cytoplasmic tail of most immunoreceptors. This Perspective highlights the mechanisms of BRS...
On the way back to @UniFreiburg after the @CIBSS_UniFR review @dfg_public - after being focused on this event for months, time to be a little unfocused or shift the focus to other things.
‼️ Don't miss the next Immunity & Infection #seminar on Monday, November 11, 2024 with Prof. Dr. Christina Zielinski @sfb1160
Delighted to share our paper on adipose gd T cells making IL-17 every night for homeostasis, coordinating lipid metabolism after eating @Nature Huge effort by @Akaron0884 & @BrennethS and the team and collaborators to work this out. Aaron's Tweetorial 👇 nature.com/articles/s4158…
Our new work led by our fantastic PhD student Jose (@j__cabezas) showing dramatic reductions in TCR-T cell cross-reactivity without modifying the TCR. Part of this work relied on SPR-based @carterra_bio to measure 163 TCR/pMHC affinities within 24 hours at 37 degrees.
I am excited to share the results from my PhD project at the @Dushek lab and my first first-author manuscript! Generation of T cells with reduced off-target cross-reactivities by engineering co-signalling receptors. biorxiv.org/content/10.110… 🧵
Just over 2 weeks left to apply! Our highly collaborative and interdisciplinary Cluster of Excellence is looking for a new colleague with expertise in #cryoEM #structuralbiology and #signaling #facultypositions #professorship
🚨 #JobAlert: W3 Professorship in Physical Chemistry with a focus on Cryo-Electron Microscopy. Join the Faculty of #Chemistry and #Pharmacy @UniFreiburg and contribute to cutting-edge research in the Cluster of Excellence #CIBSS. Apply by Nov 12, 2024! 👉 uni-freiburg.de/stellenangebot…
Come work with me at the @MedUni_Wien - I have a PhD position open which investigates CAR T cell downstream signaling!
#PhDCall 2024: Optimise #CARTcells like a #lego model! 🧬⤵ In one of our PhD projects, you can optimise the signalling pathways of CAR T cells - just like a lego model! Read more and apply now! ➡ bit.ly/3ZK6bOg @ZajcCharlotte
#PhDCall 2024: Optimise #CARTcells like a #lego model! 🧬⤵ In one of our PhD projects, you can optimise the signalling pathways of CAR T cells - just like a lego model! Read more and apply now! ➡ bit.ly/3ZK6bOg @ZajcCharlotte
Happy to hear your thoughts about this perspective! Do you think there is still space for further improvements?
REVIEW @NatRevImmunol From TCR fundamental research to innovative chimeric antigen receptor design nature.com/articles/s4157…
Excellent review from the lab about CAR design 😍 Look inside 👀
Do you know how to design innovative CAR T cells? The TCR is an incredible inspiration and has tons to teach us! Check our latest perspective in Nat Rev Immunology: rdcu.be/dXDkG You will find a new exciting way to look at CAR T cells! @CIBSS_UniFR @BUnifr @UniFreiburg
Do you know how to design innovative CAR T cells? The TCR is an incredible inspiration and has tons to teach us! Check our latest perspective in Nat Rev Immunology: rdcu.be/dXDkG You will find a new exciting way to look at CAR T cells! @CIBSS_UniFR @BUnifr @UniFreiburg
📣 Join us for the yEFIS General Assembly on 🗓️ November 12, 2024, at 5 PM CET via Zoom. 🧑💻 ✨ Connect with over 850 young immunologists, meet our task force, and discover upcoming activities and opportunities. 🔗 Register now: tinyurl.com/yEFIS4thGA (limited spots available!)
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