Anthony Rullo: chemically modulating proximity
@LabRullo
Covalent and multivalent - proximity inducing strategies for basic and translational chemical biology
قد يعجبك
In @J_A_C_S, we present TTD, a thianthrenium reagent for the in cellulo identification of protein-protein interactions based on a short-lived episulfonium intermediate. Enrichment via an alkyne tag provides high sensitivity for modified peptides. 🔓: pubs.acs.org/doi/10.1021/ja…
Rewiring the Fusion Oncoprotein EWSR1::FLI1 in Ewing Sarcoma with Bivalent Small Molecules | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/ja…
Fast and Site-Specific Covalent Targeting of Proteins by Arylfluorosulfate-Modified Aptamers | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/ja…
Cool bispecific nanobody engagers for multiple myeloma nature.com/articles/s4159…
Bulky Phosphine Ligands Promote Palladium-Catalyzed Protodeboronation | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/ja…
Chemoselective Tagging of Protein Methacrylation | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/ja…
Imine-linked covalent organic frameworks: Recent advances in design, synthesis, and application @COF_papers @MOF_papers @Molecular_Cages @POC_Papers doi.org/10.1002/smm2.1…
Imine-linked covalent organic frameworks: Recent advances in design, synthesis, and application @COF_papers @MOF_papers @Molecular_Cages @POC_Papers doi.org/10.1002/smm2.1…
Excited to share our review on Induced Proximity-based therapeutic modalities now out in Nature Reviews Drug Discovery! nature.com/articles/s4157…
🎉 New paper in Drug Discovery Today in collaboration with the Tuveson lab. “Clickable Covalent Metabolite Mimetics (CoMMs)” – nature-inspired scaffolds. Big congrats Elliot, Dharmendra, Shoujun & Adam! 🔗 lnkd.in/ey5Y7q5Q #DrugDiscovery #CovalentDrugs #ClickChemistry
Great chemical review on induced proximity in the context of cellular immunotherapy nature.com/articles/s4157…
Specific binders to peptide–MHC class II are rapidly generated without laborious screening go.nature.com/4gj5OQk rdcu.be/eMYFS
With gratitude to reviewers, we are thrilled to report on a new type of hybrid drug: Baited SELEX: Drug-Directed Selection of Aptamers to PSMA for In Vivo Targeting of Prostate Cancer in Mice pubs.acs.org/doi/10.1021/ja… @PCR_news @BeatPCa @prostatecanada @PCFNews @AptamerSociety
Development of Dual-Receptor Lysosome-Targeting Chimeras for Protein Degradation | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/ja…
"We used a very low dose, almost 100 times lower compared to the traditional small-molecule drug, and the ABC still can achieve much better efficacy compared to the small-molecule drug given on its own," says @chemistrymit postdoc Bin Liu news.mit.edu/2025/bottlebru…
A new generation of radiotherapies promises a more targeted attack on cancer. Learn more: scim.ag/3IACb1i @NewsfromScience
How to make immune cells “invisible” to facilitate allogeneic cell therapies? MIT and Harvard Build “Invisible” Immune Cells That Obliterate Cancer scitechdaily.com/mit-and-harvar…
Happy to share my lab’s work out today in @Cancer_Cell demonstrating that multiple myeloma relapses after CAR T therapy frequently express low BCMA levels. We develop novel SEMA4A-directed CAR T cells eradicating MM, especially under BCMA low conditions. authors.elsevier.com/a/1lvYf_YwcvnX…
Controlling the 3D structure of #glycans allows increased binding to proteins- not just a curiosity but a powerful concept to develop better #vaccines
Stapling of β-Glucans Increases Antibody Binding | Journal of the American Chemical Society @peterseeberger @MpiciPotsdam @FU_Berlin pubs.acs.org/doi/10.1021/ja…
Folding-mediated secretion of pure bispecific antibodies go.nature.com/48NEM2o
Today's Nobel Prize for Physiology or Medicine relates to research on regulatory T cells nobelprize.org/prizes/medicin… For readers interested in harnessing the biology of regulatory T cells to treat disease, here's a comprehensive review nature.com/articles/s4157… rdcu.be/eJHU8
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