Liisa Lutter
@LiisaLutter
Postdoctoral researcher in the Eisenberg lab at @UCLA protein folding & misfolding / neurodegeneration / amyloid / structural biology / biophysics
Just in time for Christmas! Excited to see our fibril structures published, showing changing polymorphism of IAPP during the course of amyloid assembly. As always, brilliant team effort from the amyloid team, thanks all @AstburyCentre @naranson @RadfordLab sciencedirect.com/science/articl…
Structural reconstruction of individual filaments in Abeta42 fibril populations assembled in vitro reveal rare species that resemble ex vivo amyloid polymorphs from human brains biorxiv.org/cgi/content/sh… #bioRxiv
Fantastic to see Trace_y software tools accessible for all to use in their research to do AFM image analysis of helical fibril samples.🤗 github.com/wfxue/Trace_y
github.com
GitHub - wfxue/Trace_y
Contribute to wfxue/Trace_y development by creating an account on GitHub.
Trace_y: Software algorithms for structural analysis of individual helical filaments by three-dimensional contact point reconstruction atomic force microscopy biorxiv.org/cgi/content/sh… #bioRxiv
So proud to hear that Liam won a poster prize at this weeks FASEB meeting on proton aggregation in Dublin for his super exciting data on amyloid fuzzy coats. Well done Liam!!
Our new paper on #tau : Solid-state NMR of paired helical filaments formed by the core tau fragment tau(297-391) biorxiv.org/content/10.110…
Happy life update 📢: Last week I joined the Eisenberg lab at @UCLA as a postdoctoral researcher. After an incredribly warm welcome I'm excited for new scientific adventures 👩🔬🌿
Integrating individual tau filament AFM 3D envelopes with cryo-EM structures now in @JMolBiol. Demonstrated on an excellent tau297-391 sample by @YoussraHilaly, which was most closely related to PHFs from AD tissue. Illustrative movie below & quantitative comparison in paper.
Trace_y: Software algorithms for structural analysis of individual helical filaments by three-dimensional contact point reconstruction atomic force microscopy biorxiv.org/cgi/content/sh… #bioRxiv
Happy to share our preprint combining 3 of my favourite things - AFM, cryo-EM & polymorphic amyloid fibrils.🔬 The analysis reveals that unlike heparin-induced tau, dGAE tau fibrils are structurally most closely related to PHFs from #Alzheimer's disease brain tissue.
Structural identification of individual helical amyloid filaments by integration of cryo-electron microscopy-derived maps in ... biorxiv.org/cgi/content/sh… #biorxiv_biophys
Fantastic time meeting everyone in person yesterday ❤️🔬
Wonderful to talk science, amyloid structural biology and cell biology in person again, was a wonderful day with the joint @SerpellLab and @wfxue_lab research away day in East Sussex countryside @Serpell1 💡💡💡
Amazing to be able to contribute with @LiisaLutter @LDAubrey a review of amyloid polymorphism sciencedirect.com/science/articl… for @JMolBiol AlphaFold: A Special Issue and a Special time for Protein Science, now out with a fantastic set of 19 great reviews sciencedirect.com/science/articl… 😎💡🔬
Today with @emblebi, we're launching the #AlphaFold Protein Structure Database, which offers the most complete and accurate picture of the human proteome, doubling humanity’s accumulated knowledge of high-accuracy human protein structures - for free: dpmd.ai/alphafolddb 1/
Our recent review on amyloid polymorphism with a twist of AlphaFold 2/structure prediction 😊
My group has recently written a review on our current structural knowledge of the amyloid polymorphism phenomenon. Check out our just-accepted manuscript 💡🔬😎 sciencedirect.com/science/articl…
🎉Delighted to share our work out in @Nature today 🎉 using Super-Resolution Localization methods to increase #AFM resolution beyond the limits set by tip radius, reaching at least 4Å resolution. Huge thanks and brilliant working with @ScheuringLab 🙏 nature.com/articles/s4158…
Baker lab's effort at reproducing AlphaFold2 is out on bioRxiv. Pretty impressive performance gains (relative to original trRosetta), if not quite yet at AlphaFold2 level. biorxiv.org/content/10.110…
Released today @EMDB_EMPIAR & @PDBeurope, & published @CellCellPress, the awesome 3.9 Å #CryoEM structure of the #Flagellar #Motor-Hook complex, the molecular machine that drives rotation of the #Flagellum for #Bacterial motility by Tan et al. from @ZJU_China 1/2
Been working with @phospho animation on amyloid aggregation. 1st effort is pretty stunning, I think! This is an in vitro, wild-type hIAPP fibril from @R_U_Gallardo @RadfordLab lovely paper in @NatureSMB @Astbury_BSL @AstburyCentre #LoveTheWigglyBits rdcu.be/b7bGc
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