MicroMol_Lab
@MicroMol_Lab
Microbiological, molecular biological, cell biological and immunological laboratories; interface for Research and Development; cell bank and phage analytics
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#Industrial #microbiology is a highly interesting topic of #EUROmicroMOOC (in fact all are highly interesting! 😀). Did you know what #microorganisms do besides being pathogenic? #welovemicrobiology #MicroMol
Do not miss this weeks topics!
This week in #EUROmicroMOOC at 17:00 CET 6⃣ - Microbial synthetic biology by @krisnino86 7⃣ - Industrial microbiology by @ManoloSanchezA 8⃣ - Virulence and pathogenicity by @baylorete @FEMSTweets
Carefully use #antibiotics and help us detecting #bacteriophages as an important #alternative against #multiresistant #bacteria. We welcome any sample of wet material from special, non-everyday areas (such as mud from the rainforest).
This week in #EUROmicroMOOC at 17:00 CET 6⃣ - Microbial synthetic biology by @krisnino86 7⃣ - Industrial microbiology by @ManoloSanchezA 8⃣ - Virulence and pathogenicity by @baylorete @FEMSTweets
What a great picture of our #pets #Bacteriophages
Selected representative #PhageHunter image taken and colorized by T. deCarvalho of the Keith Porter Imaging Facility @UMBCCNMS @UMBC and the @UMBCPhageHunter @UMBCBiology undergrads this year! Siphos, Myos, Podos, and Tectis, oh my! #SEAPHAGES @phagesdb @GHatfull
Was a great evening being #teacher at #EUROmicroMOOC. Who missed the training can read it at wakelet.com/@SEMicrobiolog… #Microbiology is great!
Remember that you can have access to all the lessons (also in pdf) of the course Trends in Microbiology by Twitter in the Wakelet-SEM page #EUROmicroMOOC @FEMSTweets wakelet.com/@SEMicrobiolog…
Do you have any question about our lesson “Bacteriophages”? Ask directly to your teacher @MicroMol_Lab #EUROmicroMOOC
Want to learn how to work with #Phages? Let us meet at the 4th International hands-on PHAGE BIOTECHNOLOGY course in Braga-Portugal. #MicroMol #Tentamus #Laboratory #EUROmicroMOOC bit.ly/2ofh8EA
The world first prospective multicentric, randomised, single blinded and controlled clinical trial of #phage therapy ever performed according to GMP and GCP ended in 2017. Phage community is looking forward to see the results. #MicroMol #EUROmicroMOOC phagoburn.eu
#Phage therapeutical preparations require rigorous #biosafety assessment. Parameters like #microbial #purity, #cytotoxicity, #pyrogenicity, #identity, #host range and #stability must be tested before use on patients. #MicroMol #Laboratory #EUROmicroMOOC bit.ly/2CcuBXI
The #phage phiX174 was the first "organism" to have its entire nucleotide sequence determined, a feat that was accomplished by Frederick Sanger and colleagues in 1977. #MicroMol #Tentamus #Laboratory #EUROmicroMOOC bit.ly/2wAmUEv
In 1943 Luria and Delbrück in their famous experiment using #phage T1 and E. coli cultures proved that genetic mutations arise in the absence of selection, rather than being a response to selection. #MicroMol #Tentamus #Laboratory #EUROmicroMOOC bit.ly/2PTFaBB
genestogenomes.org
Luria & Delbrück: Jackpots and epiphanies
In the early 1940s, many biologists doubted bacteria had genes. After all, they seemed to play by their own genetic rules: they appeared to lack chromosomes, meiosis, mitosis, sex, and all the other...
The genetic material is so densely packed in viron heads that a preassure of tens of atmospheres is exerted on the inner capsid walls. #MicroMol #Tentamus #Laboratory #EUROmicroMOOC bit.ly/2wwUT1n
#Phages are so specific to their hosts that they can be used for strain differentiation within one species using a method called phage typing. #MicroMol #Tentamus #Laboratory #EUROmicroMOOC bit.ly/2orRRXQ
#Phages recognize their hosts by protein structures that perfectly match the receptors on the cell surface of #bacteria. #MicroMol #Tentamus #Laboratory #EUROmicroMOOC
"Virus burst size” is a term describing the number of released virions from single bacterial cell after lysis. Usually about 100 - 1000 phages are produced in a single cell. #MicroMol #Tentamus #Laboratory #EUROmicroMOOC bit.ly/2wAvJ0T
To avoid overkilling of their host #Phages communicate via small proteins that are discharged during lysis of the #bacteria . With increasing concentrations phages become lysogen instead of lytic, what helps stabilizing the bacterial culture. #MicroMol #Laboratory #EUROmicroMOOC"
Researchers have found that some #Phages can communicate. They produce and sense chemical signals and thus can decide whether to kill or keep their hosts alive. #MicroMol #Tentamus #Laboratory #EUROmicroMOOC go.nature.com/2MS5QnM
Scientists use the #CRISPR mechanism to cut and modify any genome in the lab. The European Court of Justice ruled resulting organisms in July 2018 as genetically modified. #MicroMol #Tentamus #Laboratory #EUROmicroMOOC bit.ly/2BQHfeJ
#CRISPR is a bacterial immune mechanism against #Phage contamination. Bacterial cells that survived an infection keep the genetic information of the intruder to later recognize and precisely cut the phage DNA #MicroMol #Tentamus #Laboratory #EUROmicroMOOC doi.org/10.1016/j.cell…
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