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New Online! Mechanistic insights into cargo sorting and export from the Golgi apparatus bit.ly/49FYldq
In its first year tidyplots.org has become the go-to data viz for many life science researchers, got 620+ stars on Github, ~30K CRAN downloads, and 11 citations. Thank you for using, sharing, citing, and feedback! There is more to come 🤩 #rstats #dataviz #phd
Nature research paper: Adenosine signalling drives antidepressant actions of ketamine and ECT go.nature.com/4qPa53C
nature.com
Adenosine signalling drives antidepressant actions of ketamine and ECT
Nature - Adenosine signalling is identified as the central mechanism of action of the antidepressant effects of ketamine and electroconvulsive therapy, and newly developed analogues of ketamine...
Scientists have created the most detailed maps yet of how our brains differentiate from stem cells during embryonic development and early life go.nature.com/3LsSpuj
The protein concentration in the cytoplasm is so high that the average protein has a water hydration shell of only ≈ 10 water molecules separating it from the adjacent protein hydration shell.
How are promoter interactions coordinated during cell differentiation? In our first paper, we investigate the temporal relationship between genome folding, transcription and histone modifications during ESC differentiation. (1)
Our latest paper has just been published in Cell! doi.org/10.1016/j.cell… We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
CRISPR live-cell imaging reveals chromatin dynamics and enhancer interactions at multiple non-repetitive loci go.nature.com/49EhzA4
Congratulations Daniel, Daiji and the team! We took a loss of function approach to dissect Oct4 enhancer function in pluripotent stem cells and mouse embryogenesis! cell.com/stem-cell-repo…
New Online! Regulation of RNA-binding proteins by small biomolecules bit.ly/4nME6OF
Now online! Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions dlvr.it/TP6lWB
cell.com
Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory...
Li et al. apply base-pair resolution Micro Capture-C ultra to map chromatin contacts between individual motifs within cis-regulatory elements and reveal a unified model of biophysically mediated...
Fat storage in the body relies on specialized structures called lipid droplets. In a new Science study, researchers identified the microprotein adipogenin as a regulator of adipocyte lipid droplet size, revealing a key mechanism in lipid homeostasis. Learn more in this week's…
Ten essential tips for robust statistics in cell biology nature.com/articles/s4155… (read free: rdcu.be/eOl8q) 🧬🖥️🧪 1/3...
New: Ketogenic Diet Associated with Reduced Depression Scores in @JAMAPsych New meta analysis show ketogenic diet improves psychiatric scores compared to high carb diet. They also showed that ketogenic diet showed greater improvement than just going "low carb."
This systematic review and meta-analysis found that ketogenic diet interventions were associated with small to moderate improvements in depressive symptoms, especially in RCTs with ketone monitoring. ja.ma/4qB7nyv
Online now!✨RESEARCH: Civiletto et al identify the herb-derived metabolites thymol and carvacrol as activators of autophagy and mitophagy, and demonstrate their therapeutic potential in aging nature.com/articles/s4358… rdcu.be/eHXGm
Why does the naked mole rat have the longest lifespan and healthspan of any rodent, nearly 40 years? A 30-year long mystery unraveled @ScienceMagazine today! Its cGAS enzyme in cells has 4 missense mutations that upends its function, promoting DNA repair and suppressing…
1/ You tested 10,000 genes. 500 are significant (p < 0.05). Exciting? Maybe. But if you used raw p-values, you just got played by randomness. Let’s talk FDR.
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