The Lewis Lab
@PeterLewisLab
Chromatin biochemistry and genomics in development and cancer. @UWMadison @UWSMPH @BMC_UW
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We are excited to share our new preprint demonstrating that nucleic acid interactions with SUZ12 constrain PRC2 activity, establishing a kinetic buffer essential for targeted gene silencing and revealing vulnerabilities in diffuse midline gliomas. tinyurl.com/4yrwftrn
Mechanisms of DNMT3A–3L-mediated de novo DNA methylation on chromatin nature.com/articles/s4159…
1/ 🚀 AEBP2 isn’t what we thought. You were told that AEBP2 promotes PRC2 activity on chromatin. We found the opposite: the most prevalent AEBP2 isoform inhibits PRC2 activity. Excited to share our new paper surl.li/cgwqcq A thread 🧵
Happy to share our latest work on Polycomb repression reprogramming in early development, spearheaded by two super talented Ph.D students Yitian Zeng and Feng Kong. cell.com/cell-stem-cell…
Our work "Aquarius helicase facilitates HIV-1 integration into R-loop enriched genomic regions," is out in @NatureMicrobiol nature.com/articles/s4156…
Really excited that our manuscript on Synovial Sarcoma is now online. Link to Open Access PDF: tinyurl.com/55bnssws A summary🧵 :
@BeatrizGerFalc summarizing some of her latest work with the lab. #EZH2 controls cell plasticity in #ProstateCancer through coordination with activation of #translation and the RNA degrading protein #tristetraprolin @CPDR_Labs
Today in @Nature we share our back-to-back stories with @nzhenguw revealing chemical-genetic convergence between a molecular glue & E3 ligase cancer mutations. 1/6
The summer has been busy! Along with the move and a PhD defense, we have updated two preprints: biorxiv.org/content/10.110… and biorxiv.org/content/10.110…
Hypertranscription state in early embryos that both shapes and is fostered by the three-dimensional genome organization, revealing an intimate interplay between chromatin structure and transcription @Nature @xielablife nature.com/articles/s4158…
Online Now: Distinct specificity and functions of PRC2 subcomplexes in human stem cells and cardiac differentiation dlvr.it/TMRwWj
This work was lead by PhD candidate Cecilia Gavilan, with contributions from multiple Iwase lab members. Check it out online! buff.ly/7XaD7cN
Ever wondered what else SETD2 does beyond transcription? 🧬 Check out our new @NatureCellBio study. Awesome work from Abid Khan (@AbidKhanEpigen) showing how SETD2 moonlights to safeguard the genome during cell division. nature.com/articles/s4155…
Excited to see this published with additional data following our preprint a while back. Cool combination (in our biased view) of controlled TF expression and machine learning to decode chromatin sensitivity. sciencedirect.com/science/articl….
Excited to share our latest preprint. Lead by Sevi (@biosevi) we asked how transcription factors (TFs) with short and abundant motifs drive specific cell fates. Our test cases: Two bHLH factors that bind to seemingly similar E-boxes. 1/7 biorxiv.org/content/10.110…
Excited to share with you our latest preprint on SMARCA2/4 degraders! at the @UoDCeTPD in collaboration with #GeorgWinter´s lab. Here, we show how a Molecular Glue Degrader can covalently and redundantly recruit DCAF16 and FBXO22 to degrade SMARCA2/4 biorxiv.org/content/10.110…
(1/n) Excited to share our new preprint! We uncover that RNA actively promotes nucleation and function of pathogenic condensates, amplifying locus-specific oncogenic transcription and promoting tumorigenesis. #epigenetics #condensates #cancer #RNA biorxiv.org/content/10.110…
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