Patrick Rensen
@Rensen_Lab
Professor metabolic aspects of vascular disease I Chairman European Lipoprotein Club #brownfat #nash #circadianrhythm #atherosclerosis
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Guoli Li, Sijing Dong, Chunhao Liu, Jing Yang, Patrick C N Rensen, Yanan Wang academic.oup.com/lifemeta/artic…
Great paper of the Gerhart-Hines group just appeared in @Nature! 😊👍 Happy to have been modestly involved!
Our new paper, "NK2R control of energy expenditure and feeding to treat metabolic diseases," is out today in @Nature. Here we identify a single receptor that can both peripherally increase energy expenditure and centrally suppress appetite. nature.com/articles/s4158… 1/12 🧵👇
Just online: Liver-targeted Angptl4 silencing attenuates hyperlipidemia and atherosclerosis development in APOE*3-Leiden.CETP mice, our well-established model for human-like lipid metabolism and cardiometabolic diseases @LUMC_Leiden @Lipigon_Pharma academic.oup.com/cardiovascres/…
academic.oup.com
Liver-targeted Angptl4 silencing by antisense oligonucleotide treatment attenuates hyperlipidaemia...
AbstractAims. Angiopoietin-like 3 (ANGPTL3) and 4 (ANGPTL4) inhibit lipoprotein lipase to regulate tissue fatty acid (FA) uptake from triglyceride (TG)-ric
It was a real pleasure to give a keynote on (pre)clinical studies on #brownadiposetissue #bat at the annual meeting of the Austrian Atherosclerosis Society. Thank you so much for the kind invite! @LUMC_Leiden
Our new paper, "NK2R control of energy expenditure and feeding to treat metabolic diseases," is out today in @Nature. Here we identify a single receptor that can both peripherally increase energy expenditure and centrally suppress appetite. nature.com/articles/s4158… 1/12 🧵👇
Just published in ATVB. Kudos to Frank Schaftenaar!
Pharmacologic inhibition of the immunoproteasome with ONX-0914 attenuates atherosclerosis, metabolic syndrome, and reduces white adipose tissue mass in mice @Rensen_Lab @FoksAmanda @mariedepuydt @JilldeMol ahajrnls.org/4aolEW2
51 weeks a year a devoted scientist, one week a year absolutely not 😉🎉🎈🇳🇱
Afterparty op treinstation Malmö #eurovision #esf #ESC2024 #Netherlands #Europapa
#CETP inhibition enhances bacterial clearance to reduce pneumoniae-associated mortality in APOE*3-Leiden.CETP mice, suggesting CETP inhibitors to be repurposed to prevent #sepsis-related mortality in humans! @LUMC_Leiden insight.jci.org/articles/view/…
CETP Inhibition may well have therapeutic applications beyond targeting ASCVD, including protection against septicemia. Certainly relevant, giving that the bulk of circulating #CETP derives from #macrophages! @LUMC_Leiden @NewAmsPharma sciencedirect.com/science/articl…
Proud of @MilenaSchonke who just received an #EFSD grant to study the molecular mechanisms by which late #exercise via the #gut #microbiome improves #NAFLD! @LUMC_Leiden 👇
Proud of @KooijmanSander who was awarded a Dekker Senior Scientist grant of the Dutch Heart Foundation to dive deeper into the #circadianrhythmn of #brownfat to reveal novel (chrono)therapeutic approaches to comBAT atherosclerotic #CVD! 😊👍 #batman @LUMC_Leiden 👇
De Hartstichting feliciteert 10 toponderzoekers van @ErasmusMC, @MaastrichtUMC, @umcg, @amsterdamumc, @LUMC_Leiden, @UMCUtrecht met de toekenning van de Dekkerbeurs. Hiermee kunnen zij belangrijk onderzoek doen naar hart- en vaatziekten.
Highly recommended PhD position with a dedicated supervisor in Almería, and with the opportunity to perform part of the research at @LUMC_Leiden! 😊👍
📢We are offering a PhD position📢. Those who are interested, send me an email! @FPUinvestiga @FJIprecarios
Pharmacological inhibition of DHCR24 prevents #nash development by increasing the endogenous #lxr agonist #desmosterol! @LUMC_Leiden #patentpending 👇 lumc.nl/en/about-lumc/…
Today Huub van Eyk defended his thesis ‘GLP-1 receptor agonism to improve cardiometabolic health’, also with flying colors! Proud promotor! 😊🎉🎈 @LUMC_Leiden
.@LUMC_Leiden researchers and collaborators show that inhibition of DHCR24 decreases liver #collagen content and plasma alanine transaminase levels in an established #NAFLD model. 🔓 #OpenAccess at @EmboMolMed bit.ly/46kjCW9
Today Robin van Eenige defended his thesis ‘Targeting adipose tissue to improve cardiometabolic health’ with flying colors! All six experimental chapters, mainly supervised by @KooijmanSander have been published. Very proud promotor! 😊 @LUMC_Leiden
Combined #GIP and #GLP1 receptor agonism additively attenuate #NAFLD development. Proud of Zhixiong and Robin! 😊👍 @LUMC_Leiden @EliLillyandCo sciencedirect.com/science/articl…
Just published: a novel pharmacological approach to block #nash development by specifically activating LXRa in macrophages. Proud of @Enchen__Zhou ! 😊👍 embopress.org/doi/full/10.15…
It has been great organizing a lipid session with @PAspichueta at #EASL2023! Already looking forward to next year’s edition! 😊👍
Novel strategies to target lipid metabolism una NASH in #EASL2023 . It was a pleasure to share the session with @RubenNogueiras @Rensen_Lab #GregorySteinberg @PAspichueta
Proud of @CarlijnHoekx who gave a great flash talk at #DAS2023 on her recent paper in @CellRepMed showing that hunan #BAT is activated by #ADRB2 rather than #ADRB3! 😊👍 @AtheroNL @LUMC_Leiden
It’s not too bad to be cold 🥶 as it activates brown fat which is associated with a better #cardiovascular health Carlijn Hoekx shows how activation of ADRB2 stimulates brown fat. @UniLeidenNews #DAS2023
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