Tcipatent
@TCIPATENT
The Claimed Intermediate is a Text/Structure Searchable Online Database which covers Process Patents for Named Marketed Pharmaceutical Drugs.
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A high yielding, easily purified key intermediate A - just what's needed! Synthesis 3889 Rivaroxaban is obtained via the synthesis of X-ray defined intermediate A perchlorate salt. (Unichem Laboratories Ltd) #medicinalchemistry #drugprocesspatent #pharmaceuticals #rivaroxaban
#Celecoxib via #flowchemistry Patent Synthesis 4100 Celecoxib is obtained in a flow synthesis with the reaction of prepared intermediates 5 and 6 using flow rates, conditions and solvents as defined #medicinalchemistry #drugprocesschemistry #pharmaceuticals
I'm sure the UK Government will cover any shortfall.....haha!
Tanya Sheridan from @RoySocChem warns that UK chemistry received over £10 million less from EU sources in 2017-18 than in 2015-16 chemistryworld.com/news/brexit-un…
"Patents are designed to communicate knowledge. Indeed, they can serve as their own form of technical literature." Can and do...…!
How Companies Can Extract Value from Expired Drug Patents drugpatentwatch.com/blog/how-compa…
drugpatentwatch.com
How Companies Can Extract Value from Expired Drug Patents
Information contained in expired drug patents can be invaluable to researchers developing new products, but caution is required to avoid legal problems.
✨SYNTHESIS Editor’s Choice Time!✨If you work in the field of cycloadditions of #tropones, don’t miss this very interesting publication from @vincent_gandon @djpleboeuf and coauthors. Their contribution will be open access for the next 72 h❗ 👉fal.cn/35gpi
Specific for US Patents but general enough for most States!
Naloxegol - the 4,068th Patent Synthesis added to the Claimed Intermediate Database - Text/Structure Searchable. #Patent #Pharma #Synthesis
Relax and reduce your reaction!
To all #organicchemistry students out there who just started their new semester: be patient, be persistent and hang in there! 🔬👨🔬 You're not #diene, YOU CAN DO THIS! 😊💡
Excellent review!
To all #organicchemistry students out there who just started their new semester: be patient, be persistent and hang in there! 🔬👨🔬 You're not #diene, YOU CAN DO THIS! 😊💡
Flow chemistry appearing in patent drug syntheses - #patent, #drugsynthesis, #pharma
Success in chemistry is traditionally much more reliant on the person doing the work than in biology or physics, but that no longer needs to be the case chemistryworld.com/opinion/lesson…
Forget the water - reuse the whisky!
Success in chemistry is traditionally much more reliant on the person doing the work than in biology or physics, but that no longer needs to be the case chemistryworld.com/opinion/lesson…
Novartis team describes optimized, 6 step route to dual kinase inhibitor Dactolisib on 150 kg scale in 51% y. Pd charge in Suzuki coupling reduced to 0.3 mol% by using PPh₃ additive. pubs.acs.org/doi/10.1021/ac…
Noted CN 109796346 (Univ Dalian Tech) ..continuous hydrogenation preparation of aromatic amine through a nitro-compound - a static bed liquid phase catalysis hydrogenation process is utilized and the activity of the catalyst is not lowered after 400-hour continuous running.
Success in chemistry is traditionally much more reliant on the person doing the work than in biology or physics, but that no longer needs to be the case chemistryworld.com/opinion/lesson…
✨150 years of the remarkable work of our namegiver: Friedrich Miescher✨The Basler #scientist laid the chemical groundwork for #DNA discovery almost a century before Watson and Crick! 🧬 Read more about his legacy 👉bit.ly/2JOXafj
🤩 Erick Carreira and Moritz Hönig highlighted the great achievement of Jiasu Xu and Viresh Rawal from @UChiChemistry in the enantioselective #totalsynthesis of (–)-Ambiguine in SYNFACTS. 🧐 Well done! 👍 ➡️ Read more: fal.cn/33haf @ETH_en @CarreiraGroup
Comprehensive real drug example of continuous synthesis.
Success in chemistry is traditionally much more reliant on the person doing the work than in biology or physics, but that no longer needs to be the case chemistryworld.com/opinion/lesson…
Very interesting - more process patents include flow synthesis!
"Integration of technologies and techniques is critical for success." Paul Quigley and Samuel Bourne recently participated in a #PanelDiscussion on the application of #FlowChemistry for accelerated #DrugDevelopment. Read the @TKSpublisher article here: teknoscienze.com/tks_article/pa…
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