Z. Tariq
@TheLabDoc
Specimen consists of 🇵🇰🇺🇸trainee pathologist with foci of #SurgPath #CytoPath┃Dominus illuminatio mea┃#MedHistory #MedEd #LittleThingsInLife ☔️ 🌄 ☕️ 🏊 ✈️
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🚩Psammomatous calcification in ascitic fluid (Pap) Lamellated concentric rings Classically associated w/ serous carcinoma (ovary/Gyn tract) Look for an epithelial component (supporting malignancy; peritoneal involvement) Also consider RCC, PTC, other papillary #PathTwitter
🔬 Pleural biopsy Can you make the diagnosis from one pic, or is it #TooFarToDiagnose? #Pathology #PathTwitter
Spherule-thyroid FNA (DQ) Round cohesive cluster of follicular cells forming 3D sphere ±colloid Note bland nuclei, smooth contours Supportive of benign Dx (contextual) Contrast to microfollicles (<15 cells, scant colloid, tight sphere), suggesting follicular lesion #PathTwitter
What is this finding? In a young male patient with hematuria and hearing loss, what would be your top diagnosis? #DiagnoseThis #pathology #renal #kidneypath #pathx #pathtwitter
30s M 8cm pelvic mass, not arising from any particular organ. Dx/ddx/IHC? #PathTwitter #PathX
Herpes zoster on Tzanck smear prep ✅ 🔬 🦠 ✅ Acantholytic cells: distinct Peri nuclear halo ✅ Multinucleated giant cells :3Ms: Multinucleation, Margination of chromatin and nuclear Moulding #dermatopathology #dermatology #dermpath #pathology #pathX #PathTwitter #MedTwitter
Bubble-wrapped🫧 tumor cells of papillary RCC in a FNA kidney (DQ, CB) Loosely cohesive papillary clusters of cells w/ round uniform nuclei, closely associated w/ foamy macrophages ±hemosiderin ±psammoma bodies Workup: CK7, AMACR, CD10 MET mutations (hereditary form) #PathTwitter
Phantom yeasts: treated Cryptococcus in CSF (Pap) Note round empty spaces/halos (only capsule may remain post-Rx, major virulence factor), distorted yeast forms (poorly stained) Minimal inflammation (immune compromise CD4 <100) Mucicarmine, India ink (negative stain) #PathTwitter
Potpourri of Post Tx infections!! CMV, BKV, Mucor &Candida!! Add images of infections you come across, in comments!! #RenalBiopsy #NephTwitter #PathTwitter #RenalPathSociety #AskRenal #ISRTP #RenalPathLabsGurugram #PostTxInfections #PoojaMaheshwari
Metaplastic transformation of a #glioblastoma is relatively uncommon, but when it happens it's striking. Like this case, where the #GBM is transforming into bone. #pathology #neuropath #pathtwitter
A ser(i)ous identity crisis: Metastatic breast carcinoma in pleural fluid Malignant epithelial cells distinct from mesos (look for clusters, loss of polarity, nuclear pleomorphism ±nucleoli) Intracytoplasmic vacuoles or mucin Origin workup: GCDFP-15, mammaglobin, ER #PathTwitter
50/post menopausal female, D&C material. Mass present in anterior uterine wall. Presents with bleeding, ascites, skeletal mets in d2-d3 vertebrae. #Gynpath #Pathology #Pathresidents #PathX #Pathologists #Pathtwitter #Surgpath
A middle-aged female patient with a brain lesion, known to be medically free. In this case, what should be our initial thoughts? And what is the top differential diagnosis? #PathTwitter #Neuropath (1)
Submucosal syncytium: Granular cell tumor of esophagus 🔴Pseudoepitheliomatous hyperplasia of overlying mucosa (🚫SCC) Granular eosinophilic cytoplasm (lysosomes) Indistinct cell borders, ±interspersed blood vessels (🚫vascular lesions) Schwann cell origin (S100+) #PathTwitter
Ecchordosis Physaliphora, a hamartomatous lesion of notochord remnants. IHC identical to chordoma. Unlike chordoma it 1) Benign 2) No growth potential 3) No lobular architecture #pathx #pathtwitter #neuropath #neuropathology #cnspathology
Seen in necrotizing granulation tissue in superficial arm mass of 20s F. Mysterious objects are lurking. Can you name them? #fungus #PathX #PathTwitter #pathbugs
Ironclad: hepatic hemochromatosis Coarse golden-brown iron granules (initially Zone 1 hepatocytes if primary/HH) ±hepatocyte damage. Periportal fibrosis (bridging) > micronodular cirrhosis (seen on low power) Iron should usually be confirmed w/ Prussian blue stain. #PathTwitter
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