Tim Schleimer
@Tim_Schleimer
Research associate & PhD student @ Bochum University of Applied Sciences & The Parker Institute Copenhagen
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Stopping weight loss drugs is followed by weight regain and reversal of beneficial effects on heart and metabolic health markers like high blood pressure, finds BMJ review. Regain was faster than after behavioural weight management programmes @_WestSam bmj.com/content/392/bm…
Cannabis-Based Products for Chronic Pain: An Updated Systematic Review acpjournals.org/doi/10.7326/AN…
** NEW PAPER in BMJ ** "AMSTAR-PF: a critical appraisal tool for systematic reviews of prognostic factor studies" Allows the quality of prognostic factor reviews to be examined. Brilliantly led by Michael L Henry. bmj.com/content/391/bm…
A TRIUMPH for the GCGR-GLP1R-GIPR triple agonist Retatrutide in P3. Participants with #obesity and knee osteoarthritis taking retatrutide 12 mg lost an average of 28.7% of their body weight at 68 weeks. Mild dysesthesias noted #weightloss #arthritis investor.lilly.com/news-releases/…
Long term trial data confirm minimal benefit of arthroscopic subacromial decompression for subacromial pain syndrome bmj.com/content/391/bm…
New BMJ Research: Benefits and harms of ADHD interventions. This umbrella review indicates that although some drug interventions offer medium to large benefits in the short term for management of ADHD symptoms, they can be poorly tolerated bmj.com/content/391/bm…
We just preprinted a huge meta-meta-analysis examining the effects of exercise on cognition, memory, and executive function. In short: - 2,239 effect sizes - extreme between-study heterogeneity - extensive publication bias - some subgroup/exercise-specific effects More below
A new analysis of the SELECT trial confirms semaglutide lowers the risk of major heart problems in people who are overweight or obese and already have heart disease, even if they don’t have diabetes. Explore the research 👉 hubs.li/Q03Prz070
In patients with knee osteoarthritis, aerobic exercise is likely the most beneficial exercise modality for improving pain, function, gait performance, and quality of life, finds study bmj.com/content/391/bm…
📢 New in @LancetLongevity: The largest trial of #yoga and falls prevention showed Iyengar yoga increased falls in older adults. Yoga has many health benefits, but this style is not recommended for fall prevention. 👇 sciencedirect.com/science/articl… #fallsprevention #healthyageing 🧵
The TARGET guideline has been published today in JAMA and the BMJ. We hope this guideline helps researchers report studies that use observational data to estimate effects of interventions. jamanetwork.com/journals/jama/… bmj.com/content/390/bm… @UNSWMedicine @neuraustralia
Impressive results.... Personalised gait retraining for medial compartment knee osteoarthritis: a randomised controlled trial 👇👇👇 thelancet.com/journals/lanrh…
NEW RESEARCH—Cognitive functional therapy, with or without movement sensor biofeedback, produced sustained effects at 3 years versus usual care for people with chronic disabling low back pain bit.ly/3Jm6nwP
Efficacy of a Very-Low-Calorie Weight Loss Diet Plus Exercise Compared With Exercise Alone on Hip Osteoarthritis Pain: A Randomized Controlled Trial: Annals of Internal Medicine: Vol 0, No 0 acpjournals.org/doi/10.7326/AN…
🦵Our new published trial (RCT + parallel preference arm) in @AnnalsofIM suggests HTO can be disease-modifying for knee OA & varus alignment HTO + non-surgical care slowed disease progression and improved pain & function over 2 years 🔗 acpjournals.org/doi/10.7326/AN… #KneeOA #HTO
Clinical and cost-effectiveness of a cycling and education intervention versus usual physiotherapy care for the treatment of hip osteoarthritis in the UK (CLEAT): a pragmatic, randomised, controlled trial thelancet.com/journals/lanrh…
Booster sessions for maintaining the effect of neuromuscular exercise and progressive resistance training in hip osteoarthritis: 12-month follow-up from a multicenter cluster-randomized controlled trial pubmed.ncbi.nlm.nih.gov/40712915/
Original Article: Tirzepatide as Compared with Semaglutide for the Treatment of Obesity (SURMOUNT-5 phase 3b trial) nej.md/44ZeMPz @EASOobesity | #ECO2025
This updated SPIRIT 2025 (Standard Protocol Items: Recommendations for Interventional Trials) explanation and elaboration document provides guidance on protocols of randomised trials for researchers bmj.com/content/389/bm…
Input needed from clinical researchers and methodologists who have knowledge of patient reported outcomes, minimum clinically important differences, and possibly change vs absolute status: discourse.datamethods.org/t/challenges-i…
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