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Our latest work: As it turns out different positive allosteric modulators bind to different sites at the mu opioid receptor. Find out more in our @biorxivpreprint. biorxiv.org/content/10.110…
A take on the current state of biased signaling in psychedelic action and psychedelic drug discovery by John McCorvy and I: Biased Signaling in Psychedelic Action | Annual Reviews - go.shr.lc/4lx1pLf
Job Alert! Open Postdoc position in membrane protein structural biology, molecular pharmacology @ drug discovery in New York. More info can be found here: wackerlab.com
Lessons from a Toad Psychedelic about the Role of different Serotonin Receptors in Psychedelic Physiology: nature.com/articles/s4158… Congrats to Audrey and @LankriDavidIL in this collab with @SamesLab and @ScottRusso published in @Nature
Asenapine as a potent TAAR1 agonist nature.com/articles/s4146… Congrats @NeuroStructure
nature.com
Molecular basis of human trace amine-associated receptor 1 activation
Nature Communications - hTA1 is a drug target for several neuropsychiatric disorders. Using cryo-EM and pharmacological assays, the authors illuminate hTA1’s similarity to neurotransmitter...
Tetracyclic antidepressants potently activate serotonin receptors 5-HT1e and 5-HT1F, explaining some of their clinically observed effects. @NeuroStructure @martafilizola @biorxivpreprint @biorxiv_neursci biorxiv.org/content/10.110…
Also, here is our @biorxivpreprint on the structure and pharmacological properties of human TAAR1 biorxiv.org/content/10.110…
Happy to share our new @biorxivpreprint: “Architecture of the human erythrocyte ankyrin-1 complex” from Clarke lab (first author the incredibly talented @Frances84469032) and collaborators @lab_cali and @alexjamesnoble! Read on to find out more (it was a surprise package…):
Peer-reviewed version of @filizolalab1’s ‘Mechanism of μ-Opioid Receptor-Magnesium Interaction and Positive Allosteric Modulation’ is now available on @biophysJ - ScienceDirect sciencedirect.com/science/articl…
EXCITING NEWS! Dr. Denise J. Cai receives prestigious @NIH Director’s New Innovator Award from the @NIH_CommonFund’s High-Risk, High-Reward Research program! A HUGE CONGRATULATIONS to @denisejcai on this great honor!🍾🎉🌟 PRESS RELEASE: ow.ly/tO5y50wycTn
I am currently looking for a motivated Postdoc to join our team to work on the structure and function of neurotransmitter receptors and transporters. Spread the word! More info on our lab webpage wackerlab.com
Graduate student position available in my lab for highly motivated student!
Online now at Cell: VEGAS as a Platform for Facile Directed Evolution in Mammalian Cells zpr.io/gJjGU
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