WilsonLab
@WilsonLab2
Ribosomes & Translation Regulation; Antibiotics & Resistance Mechanisms; Structural Biology & Cryo-EM; University of Hamburg.
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Our latest work on structures of translation initiation complexes trapped by natural product inhibitors kasugamycin, edeine and GE81112 is out in the Biorxiv…biorxiv.org/content/10.110…
Out Now! A generative artificial intelligence approach for the discovery of antimicrobial peptides against multidrug-resistant bacteria bit.ly/3KzLwqv #ArtificialIntelligence #AntimicrobialPeptides #MultidrugResistance
Structural basis of enhanced stalling efficiency of an engineered ribosome arrest peptide - PubMed pubmed.ncbi.nlm.nih.gov/41099701/
We are hiring…position suitable for PhD student with interest in ribosomes, antibiotics and cryoEM… uni-hamburg.de/en/stellenange…
Save the Date for RNA 2026 in Montreal, Canada!
BREAKING NEWS The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”
See also accompanying paper from Carol Gross' lab with a similar approach in Bacillus subtilis: cell.com/cell-systems/a…
Took a bit longer than I wanted, but out now @CellSystemsCP very proud of this work, game changer for genetic interaction studies in bacteria IMHO: cell.com/cell-systems/f…
Genome-wide dual CRISPRi-seq! Knocking down every gene with every other gene in the pneumococcus, identifying > 4000 genetic interactions (GIs), most of which have never been reported. biorxiv.org/content/10.110…
GCN1 couples GCN2 to ribosomal state to initiate amino acid response pathway signaling | Science science.org/doi/10.1126/sc…
Thrilled to share our latest paper now out in @ScienceMagazine 🎉🤩 We investigated a century of plasmid evolution 🧬 and uncovered how they have adapted to the antibiotic era 💊 science.org/doi/10.1126/sc…
Life’s “operating system” is a universal genetic code. For billions of years it seemed frozen. In ChemCatChem we explain why it looks this way - and how we might carefully expand it. DOI: doi.org/10.1002/cctc.2… #GeneticCode #LifeEngineering #SyntheticBiology #Xenobiology
Pre- and postantibiotic epoch: The historical spread of antimicrobial resistance | Science science.org/doi/10.1126/sc…
Deep-mining the archaeal proteome for antibiotics | Nature Microbiology nature.com/articles/s4156…
In the latest issue! SPIDR enables multiplexed mapping of RNA-protein interactions and uncovers a mechanism for selective translational suppression upon cell stress dlvr.it/TNBk21
Early-career scientists: here’s your chance to lead independent research!🌟Max Planck Research Groups offer 6+ years, up to €2.7M in funding, open-topic freedom, team support & tenure-track opportunities. Intrigued? 😃Apply by Oct 14, 2025! mpg.de/career/max-pla…👉
Evolution of drug-binding residues in eukaryotic ribosomes - PubMed pubmed.ncbi.nlm.nih.gov/40944914/
Looking for a new approach to studying or eliminating phages? Check out our study introducing anti-phage ASOs (antisense oligos) out in @Nature today. nature.com/articles/s4158…
New online! Integrated structural biology of the native malarial translation machinery and its inhibition by an antimalarial drug bit.ly/4mluP07
Our #CryoET story on how a top antimalarial drug candidate perturbs the native malarial translation machinery is out @NatureSMB🥳rdcu.be/eBbrH Massive team effort led by @leonie_anton @mehsehret @Wenjing_Cheng_ in collaboration with @DziekanJerzy @CowmanAlan #teamtomo
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