Alex Merk
@axmrk_
stats | psy | genomics | fin(tech) | langs | post-rock | hiking | 2wheels | (kite)surf
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Alex Young: IQ, disease and statistical genomics razibkhan.com/p/alex-young-i… This week on the Unsupervised Learning Podcast, Razib talks to returning guest Alex Young of UCLA and Herasight. Trained originally as a mathematician, Young studied statistics and computational biology…
An impressive paper giving precise estimates of heritability from whole genome data. However, although framed in terms of missing heritability, they only compare their estimates to 'pedigree' estimates from UKB, not twin or Loic's own recent sib estimates, which are often…
We are pleased to announce that our new study explaining the missing heritability of many phenotypes using WGS data from ~347,000 UK Biobank participants has just been published in @Nature. Please check out our manuscript here: nature.com/articles/s4158….
Further progress on closing the “missing heritability” gap “On average … we find that WGS captures approximately 88% of the pedigree-based narrow sense heritability: that is, 20% from rare variants (MAF < 1%) and 68% from common variants (MAF ≥ 1%” nature.com/articles/s4158…
“You can stack the genetic deck ahead of time, minimizing disease burden, making sure they have a decent level of cognitive ability, low level of psychopathology proneness... That's probably going to be as effective or more effective than a lot of things parents already do.” —…
I’m thrilled to dive into the world of polygenic embryo testing (PGTP) & ImputePGTA with Jonathan Anomaly, Director of Communications @herasight delighted that Herasight is choosing to share their newest tech, ImputePGTA for the first time: youtu.be/Fm6AWfa-HW4 #pgta #pgtp
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ImputePGTA & PGTP Explained: The Latest in Polygenic Embryo Testing w...
Would you want to pick the height and IQ of your kids? Advances in genetic testing are giving parents incredible new insights into the traits of their future children. @Brook Silva-Braga goes inside the company that's pushing the ethical and scientific boundaries.
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The timeline flip will surprise many, but embryo screening polygenic traits like IQ is going to be a mass-market consumer good extremely quickly, when it springboards on PGT-A. Many bioethicists criticized PGT-P on "accessibility" grounds that already look ridiculous.
Herasight has done it again! Now they've invented a way to take some of the most readily available data from IVF clinics and get accurate polygenic scores from it That means Herasight can help any couple do embryo selection! And they want to prove it with 90% off testing!
We’re offering a 90% discount to the first qualified customer from each country in the world (T&Cs apply). Contact us if you’re interested in testing your embryos: herasight.com/get-early-acce…
Today parents can, for the first time, access polygenic embryo testing for IQ and many diseases through a routine test (PGT-A) done worldwide and in 60% of US IVF cycles. Read on to learn how Herasight’s ImputePGTA algorithm is enabling polygenic testing in IVF to go global. 🧵
Excited to get this preprint out! I wanted to highlight the phasing aspect of our pipeline for embryo reconstruction from PGT-A data, which I found particularly interesting as it required developing new methods to achieve the level of accuracy required for ImputePGTA.
Today parents can, for the first time, access polygenic embryo testing for IQ and many diseases through a routine test (PGT-A) done worldwide and in 60% of US IVF cycles. Read on to learn how Herasight’s ImputePGTA algorithm is enabling polygenic testing in IVF to go global. 🧵
Done IVF or considering IVF? Sign up here: herasight.com/get-early-acce… Herasight has already served people from 11 countries across Europe, North America, and Asia. Now we’re offering a 90% discount to the first qualified customer from each country in the world (T&Cs apply).
Today parents can, for the first time, access polygenic embryo testing for IQ and many diseases through a routine test (PGT-A) done worldwide and in 60% of US IVF cycles. Read on to learn how Herasight’s ImputePGTA algorithm is enabling polygenic testing in IVF to go global. 🧵
Check out our new paper on the genetics of educational fields in @NatureGenet Open access link: nature.com/articles/s4158…
We’re proud of this achievement which has been almost four years in the making. Stay tuned for CogPGT 2.0, which will have more variants and more advanced methodology. Exciting times in genomics!
Today we reveal CogPGT, the world’s most powerful genetic predictor of IQ. We achieve a correlation with IQ of 0.51 (0.45 within-family). Herasight customers can boost the expected IQ of their children by up to 9 points by selecting the embryo with the highest CogPGT score. 🧵
Interested in using CogPGT in your IVF journey? Sign up here: herasight.com/contact-us/. Check out the CogPGT validation whitepaper here for all the scientific details: herasight-project.webflow.io/technical-pape….
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Building on @JonathanAnomaly's thread last week, we find no evidence of negative off-target effects from screening for cognitive ability. In fact, our results highlight diverse and positive pleiotropic effects for SES, mental health, physical health, etc.
Today we reveal CogPGT, the world’s most powerful genetic predictor of IQ. We achieve a correlation with IQ of 0.51 (0.45 within-family). Herasight customers can boost the expected IQ of their children by up to 9 points by selecting the embryo with the highest CogPGT score. 🧵
We analyzed off-target effects of selection for IQ by correlating CogPGT with other outcomes, including behavioral phenotypes in 9-10 year olds. We find almost* uniformly beneficial correlations, including reduced ADHD symptoms and autistic traits with higher CogPGT score. *only…
Today we reveal CogPGT, the world’s most powerful genetic predictor of IQ. We achieve a correlation with IQ of 0.51 (0.45 within-family). Herasight customers can boost the expected IQ of their children by up to 9 points by selecting the embryo with the highest CogPGT score. 🧵
Herasight have set a new standard in genetic prediction of Type 1 diabetes. T1D straddles the boundary between PGT-M (for single gene disorders) and PGT-P (for polygenic). There's an outsized contribution from risk alleles in the HLA region, so in families with a parent that…
1/ We’re launching the world’s best Type 1 Diabetes predictor. It captures risk in key immune system genes and across millions of other genetic signals. Couples can now greatly reduce the risk of passing on this disease to their children. 🧵
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