Jeffrey Pullin
@jeffreypullin
PhD Student at the MRC Biostatistics Unit, University of Cambridge | Gates Cambridge Scholar | Bioinformatics, genetics, statistics
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I'm incredibly excited to announce that I've been awarded a @Gates_Cambridge scholarship to do a PhD at the @MRC_BSU at @Cambridge_Uni with @chr1swallace, looking at improving methods for genetic colocalization analysis.
🙌 We're delighted to introduce the next cohort of @Gates_Cambridge scholars! Gates Cambridge aims to build a global network of future leaders dedicated to improving the lives of others. 77 scholars from 32 different countries will join us this year 👇 bit.ly/3o7Ag9H
Incredibly proud of PhD student @htanudisastro from my team, who just gave a fantastic #ASHG24 talk on the impact of tandem repeat variation on cell type-specific expression. Check out her preprint: biorxiv.org/content/10.110…
Two #ASHG2024 / #ASHG24 talks tomorrow from the TenK10K collaboration between the Centre for Population Genomics and @drjosephpowell’s team, which has now done WGS + blood scRNA-seq on ~1,800 people. Lots of cool biology to discuss!
Really excited to have this out: a cell type-specific map of the impact of an understudied class of genetic variation (tandem repeats) on gene expression, at serious scale: nearly 1800 people with both WGS and blood scRNA-seq. So much signal!
📢 New preprint alert: We’ve just published a deep dive into the role of tandem repeats (#TRs) in single-cell gene expression across the immune system, using #WGS and #scRNA-seq data from 1,790 individuals and over 5 million blood cells! 🧬 🧵👇 #repeats #SingleCell 1/9
📢 New preprint alert: We’ve just published a deep dive into the role of tandem repeats (#TRs) in single-cell gene expression across the immune system, using #WGS and #scRNA-seq data from 1,790 individuals and over 5 million blood cells! 🧬 🧵👇 #repeats #SingleCell 1/9
Have a rare disease GWAS and want to increase your number of significant loci by 500%*? Then check out this great new method from @chr1swallace and Andy Bass *500% not guaranteed, but it's what they get in a real data example in the paper....
Very happy to share the first paper from my PhD on adding variant-specific information to coloc! Do check it out if you are a user of coloc
Variant-specific priors in colocalisation analysis biorxiv.org/cgi/content/sh… #biorxiv_genetic
Variant-specific priors in colocalisation analysis biorxiv.org/cgi/content/sh… #biorxiv_genetic
We are looking for a postdoc bioinformatician to work on cutting edge spatial omics analysis and methods development. This is a joint role with my lab in Bioinformatics and Advanced Technology at WEHI. There will be really cool spatial data to play with! wehi.wd3.myworkdayjobs.com/en-US/WEHI/det…
I'm incredibly excited to announce that I've been awarded a @Gates_Cambridge scholarship to do a PhD at the @MRC_BSU at @Cambridge_Uni with @chr1swallace, looking at improving methods for genetic colocalization analysis.
🙌 We're delighted to introduce the next cohort of @Gates_Cambridge scholars! Gates Cambridge aims to build a global network of future leaders dedicated to improving the lives of others. 77 scholars from 32 different countries will join us this year 👇 bit.ly/3o7Ag9H
A comparison of marker gene selection methods for single-cell RNA sequencing data bio.papers.bar/paper/c04afcfa… Single-cell RNA sequencing has enabled scientists to catalogue and probe the transcriptional heterogeneity of... 🧵 👇
The authors attribute the difference to the different formulas used for computing fold changes.
Thanks for highlighting this part of our paper @slavov_n! Hopefully greater awareness of these issues will lead to more consistency in the future.
The results of different methods applied to the same scRNA-seq data differ substantially. This is true even for fold changes, as shown below for Seurat and Scanpy. The differences between selected transcript "markers" are even larger: biorxiv.org/content/10.110… via @davisjmcc
#SingleCell #Genomics (1/6) Our computational toolkit for personalised haplotype assembly and crossover profiling using single gametes is out @NAR_Open! Supervised by @heejungshim and @davisjmcc academic.oup.com/nar/advance-ar…
🏆 Congratulations to the inaugural winners of the @StatSocAus Venables Award: Sam Nelson, @lookayzee & @petra_kuhnert! 🏅Congratulations also to the runner-ups @MattCowgill and @westgatecology, @daxkellie, Matilda Stevenson & @peg_newman ! statsocaus.github.io/venables-award/
Multiple testing exercise: spot the non-nulls! This plot shows 100 z-statistics in 10 independent groups (vertical stripes). Each true parameter βj is estimated with N(0,1) error, and estimates in the same group have correlation 0.8 Five βj values are nonzero. Can you see them?
#Stumple 85 🏏 - 3/8 ⬛⬛⬛⬛🟩⬛⬛ ⬛🟩⬛🟨🟩⬛🟨 🟩🟩🟩🟩🟩🟩🟩 The daily wordle just went next level 👏 @stumplegame
My top excel tip is to close it and download RStudio
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