Nils Gauthier's Lab
@lab_gauthier
Our goal is to understand the roles of mechanical signals generated at the interface between membrane and cytoskeleton during tumor-associated biological events
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Our new discoveries on the transitions and dynamics of Spectrin molecular topologies in the mammalian cortex (not neurons or RBC only....) using expension microscopy and computational modeling with the group of Padmini Rangamani in UCSD. biorxiv.org/content/10.110…
Delighted to see this long-running collaborative project with @Sarah_R_Barger, Daan Vorselen, @lab_gauthier, and Julie Theriot published @eLife! doi.org/10.7554/eLife.… #actin #myosin #phagocytosis
LLSM (performed @AICjanelia) also allows observations of failed phagocytosis attempts and, when combined with microparticle TFM, measuring forces produced by cells that are stubbornly making repeated attempts at eating a particle.
Our new work with Sarah Barger and Daan Vorselen form Mira Krendel and Julie Theriot labs. Lattice light-sheet and deformable beads!! A fantastic collaborative effort born from human interactions during a MBI conference in Singapore in 2018!!! biorxiv.org/content/10.110…
COME ON US...count faster!!!!!....get rid of the Carrot Pig.....we are boiling to get this one and probably only good news for 2020!!!!!
One of our movies on the nuclear compression...enjoy the action-reaction of spectrin and actin upon compression relaxation allowed by our new device in IFOM.... (look at the nucleus on the right under the compressive piston)
the yin & yang of the cell cortex: check out how actin🟣 fires up when spectrin🟢 is displaced by compressive stress. Tremendous effort by the @lab_gauthier rdcu.be/b8iPp #mechanobiology #Microscopy
That's how we should look at the cell with Spectrin Check the Spectrin behaviour in cortex organization nuclear mechanics and motility modules.....
What if actin was not the one and only........ A bit of spectrin outside of neurons or red blood cells Find out our new paper nature.com/articles/s4146…
#ASAP Wherever you desire: Fluorescent probes from the @matile_group to image local membrane tension changes in any MOI (e.g., Golgi, ER, mitochondria, peroxisomes, endosomes): bit.ly/2ZYeB5q
We arrive later to the Twitter party, but we make it with a splash; check out our recent paper at @NatureCellBio ! Super-resolution and cell stretching to study protein deformations and reorganizations inside mechanosensitive structures. nature.com/articles/s4155…
nature.com
Cell stretching is amplified by active actin remodelling to deform and recruit proteins in mechan...
Nature Cell Biology - Massou et al. combine cell stretching, super-resolution imaging and single-protein tracking to investigate integrin-based mechanosensing in live cells.
Our new collaborative paper with Nir Gov and Voituriez group is accepted!! Bravo to Jonathan. You can soon find it in PRR. arxiv.org/abs/2003.03788
Cells may be able to play the guitar.
"Force-exerting perpendicular lateral protrusions in fibroblastic cell contraction" described by Padhi et al. nature.com/articles/s4200… #mechanobiology
Please have a look at the new issue of @MBoCjournal - the Fourth Special Issue on Forces on and Within Cells. Thanks to Issue Editors Dennis Discher, Alexander Dunn, Valerie Weaver, and Alpha Yap. Also check out the cover image by Janet Iwasa @janetiwasa! molbiolcell.org/toc/mboc/31/16
Very happy as to our paper (10.1038/s41467-020-17091-x) coming out @NatureComms on how the I-BAR protein IRSp53 shapes membrane and coordinates polarity during lumen formation in glandular tissues. Remarkable is the CLEM analysis of the AMIS
Our paper on the NuMA-Dynein mitotic interaction is out: congrats to everyone for the nice work! @LabMapelli @spasqualato @IEOufficiale sciencedirect.com/science/articl…
We are very proud to (virtually) host Mike Sheetz @bmb_utmb next Friday, July 10th (1 pm CEST). The "pioneer of mechanobiology and biomechanics" will talk about the inception to current day explosion of the very same. Join us via #zoom!
Our new findings are out. This was a tremendous effort form all of us and particularly Pascale. Hope this will help in the understanding of this damned cancer! Adaptive mechanoproperties characterize glioblastoma fitness for invasion biorxiv.org/content/10.110…
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