KALLEL Labs
@labs_sir
KALLEL is a gerotech company that combines the study of aging with technology to extend human healthspan. AI-generated art on display.
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Major milestone achieved by LRI's Dr. Boominathan and her team who - for the first time - allotopically expressed a mitochondrial gene in vivo and showed successful incorporation into the electron transport chain in mammals (mice). lifespan.io/news/nuclear-e… By: @ArkadyMazin
lifespan.io
Nuclear Expression of a Mitochondrial Gene in Mice
Scientists from the Longevity Research Institute (LRI), which was formed by the merger of SENS Research Foundation and Lifespan.io, have achieved expression of an essential mitochondrial […]
Spatial Omics enthusiasts!! Spatial Proteomics is the Method of the Year 2024 🤩🤩🤩 nature.com/nmeth/volumes/…
Sequencing human genomes & transcriptomes is relatively easy compared to sequencing the proteome. The reason stems in part from their respective sizes: blog.slavovlab.net/2023/09/23/the…
Did you know that 93% of your longevity is determined by your lifestyle, not your genetics? Great convo today w our CEO @ericverdin and @drmarkhyman on the Dr Hyman Show pod
Just 1.2 to 1.6 minutes of vigorous physical activity per day is associated with a 30% reduction in major cardiovascular events, a 33% lower risk of heart attack, and a 40% lower risk of heart failure. That's less than two minutes of vigorous exercise daily, and the impact on…
High concentrations of sucralose inhibit SIRT1 & induce inflammation in brain-derived microglia cells. These are high doses (10-50 mM) so whether this is relevant to long-term consumption of sucralose will require further study onlinelibrary.wiley.com/doi/10.1002/fs…
Longevity news: 40 months of treatment of monkeys with the diabetes drug metformin was associated with younger ages in ProteinAge, DNAmAge & TranscriptAge clocks, compared to an untreated group. DNAmAge of major organs was 3-6 years younger
Metformin and monkeys: what can we learn about delaying aging? nature.com/articles/s4168…
🌟 DeSci Serendipity: DeSci Workshops! 🌟 🎥 “First Approval workshop ” by @FirstApproval #DeSci #DecentralizedScience #Workshops #Innovation
Open Genes—a new comprehensive database of human genes associated with aging and longevity academic.oup.com/nar/article/52… @OpenGenes @CRafikov
Curiosity at its finest🐢📷 Fun fact💡From tiny cute hatchlings to towering giants! Adult male Aldabra giant tortoises can reach up to 1.3m (4ft) and weigh as much as 350kg (770lbs)🐢 📷@iotaseychelles
"Our results reveal that whenever handwriting movements are included as a learning strategy, more of the brain gets stimulated, resulting in the formation of more complex neural network connectivity...typewriting do[es] not activate...networks the same way that handwriting does."
![prmshra's tweet image. "Our results reveal that whenever handwriting movements are included as a learning strategy, more of the brain gets stimulated, resulting in the formation of more complex neural network connectivity...typewriting do[es] not activate...networks the same way that handwriting does."](https://pbs.twimg.com/media/GdkK_TjboAQ-7dE.jpg)
Gene regulation involves thousands of proteins that bind DNA, yet comprehensively mapping these is challenging. Our paper in @NatureGenet describes ChIP-DIP, a method for genome-wide mapping of hundreds of DNA-protein interactions in a single experiment. nature.com/articles/s4158…
Omega-3s broadly seem to have pharmacological potential similar to that of a drug, but a risk profile more akin to nutrient. For most people, taking about 2g per day [EPA + DHA] increases omega-3 index from 4% to 8%, which is associated with a 5-year increase in life expectancy
"Large language models surpass human experts in predicting neuroscience results" w @ken_lxl and BrainGPT.org. LLMs integrate a noisy yet interrelated scientific literature to forecast outcomes. nature.com/articles/s4156… 1/8
Behold the #FountainOfYouth brought to life! ✨ On one side, the wisdom of age; on the other, the vitality of youth. This artwork captures the magical transformation of time and the allure of eternal rejuvenation. 🌿💧 #AIBio_Art, #AntiAging, #fountain_of_youth
Stronger promoters not only transcribe more RNA but also show higher effective translation rates.
The time of day when we eat is crucial for our health A study shows that eating more than 45% of our calorie intake after 5 p.m. alters glucose levels, with serious consequences for health uoc.edu/en/news/2024/t…
In just 10 days of eating whole, unprocessed foods and practicing a few simple habits, you can reduce symptoms of all diseases by 70%. From migraines to depression to IBS, the connection between what you eat and how you feel is undeniable. No drugs, no deprivation—just real…
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