Leon Smyth
@lcdsmyth
Neuroimmunology, meningeal stroma, and barriers 🦠 🧠 | Group Leader @MonashUni | former @kipnislab @wustl postdoc
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I am excited to share our latest research on the arachnoid barrier, a crucial yet poorly understood structure that partitions the CNS and the dura, out today @Nature. We discovered that gaps in this barrier allow communication between the CNS and the dura. nature.com/articles/s4158…
As in life, academia is about overlapping stages. Now it's one of those moments: closing (euphemism for paper under consideration) my PhD work at @RuiBenedito_ lab while starting an exciting new chapter as a postdoc with @StefanieDimmel1. Tweetorial ahead👀doi.org/10.1101/2025.0…
Clearance of intracranial debris by ultrasound reduces inflammation and improves outcomes in hemorrhagic stroke models - @StanfordRad go.nature.com/4nO5s71
Therapeutic VEGFC treatment provides protection against traumatic brain injury-driven tauopathy pathogenesis: @CellReports cell.com/cell-reports/f…
Happy to share our latest work led by two talented PhD students, Kevin Ziegler and Aydan Askarova, examining cell type contributions of vascular cell types to dementia risk. Many thanks to the donors, and for support from @UKDRI and @alzassociation. cell.com/neuron/fulltex…
Our glial circadian atlas in AD and aging mice is now out in @NatureNeuro! Congrats to @patwsheehan for incredible work and to our collaborators @johnthefryer, @CarpeRibosomam, @darshan1s, Ron Anafi, and the team. @johnthefryer and I started this in 2019! nature.com/articles/s4159…
T-ALL exploits a neural proinflammatory pathway to colonize the meninges @jclinicalinvest jci.org/articles/view/…
Tertiary lymphoid structures in a subset of gliomas that show signs of functional adaptive immune activation and are associated with longer overall patient survival and an immune-permissive tumor microenvironment @ImmunityCP @K_Imkeller 🇩🇪 cell.com/immunity/fullt…
Excited to share new work from the lab showing that loss of AD risk gene Ms4a4a promotes abeta clearance and protects against amyloid plaque accumulation in a mouse model 🧠🐭 @WashUMedADRC @alzassociation alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…
Congratulations, @tmamuladze for this very well deserved recognition by @WashUdbbs 👏👏👏
Next #ReThinkNeuroimmunology (#RTN2026) will be at the @WeizmannScience 🤩 We are so excited to come back to peaceful Israel 🇮🇱
Spotlight in @ImmunityCP Fibroblasts are not so scar-y in brain injury cell.com/immunity/fullt… on nature.com/articles/s4158… @Nature
Thank you for the wonderful @NeuroCellPress Preview write-up about our recent publication on the velum interpositum (the VI-P of the leptomeninges) @SiegenthalerLab. I'm just disappointed that I missed out on such a good play on words. cell.com/neuron/abstrac…
Excited to share our new paper out in @NeuroCellPress today! Ever wondered how peripheral #myeloid cells get into the #brain? We discovered it's a leptomeningeal structure called the velum interpositum. Check it out here: authors.elsevier.com/c/1lCYs3BtfHC~…
I’m very happy to share the preprint of one of the projects I’ve been working on during my postdoc in Michal Schwartz’s lab at the @WeizmannScience 🧠 Alzheimer’s disease disrupts bone marrow myelopoiesis, leading to systemic immune dysfunction. biorxiv.org/content/10.110…
It is debated whether poor #blood flow underlies white matter loss in #aging. Our recent study in aged mice supports this idea: Impaired drainage through rare, deep-reaching #venules causes mild #hypoperfusion that triggers inflammation and demyelination. nature.com/articles/s4159…
Find out more about #ANS2025 symposia for the Hobart 2025 ANS meeting including "New insights into the roles of cerebrovasculature in nutrient supply, waste removal, neurodegenerative diseases and beyond" here: ans.org.au/ans-asm/program
& I'm going to repost this 🧵, there's 1 more day for comment: consultations.health.gov.au/health-economi… AND it's IMPORTANT @nhmrc @healthgovau @Mark_Butler_MP @Mon4Kooyong @ScienceAU @AAMRI_Aus @Science_Academy @AAHMS_health @uniaus @ConversationEDU @AusSMC @ScienceAlert @DrShaneRRR @bairdjulia
Dear Everyone, I've read the #NHMRC draft strategy and I have notes ... So I'm going to...🧵🤔🧵😱🧵😵💫🧵🙏🧵🧵🧵 #NHMRCdraftStratergy #Ihavenotes #ValueFundamentalScience
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