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What impact does hearing loss have on dementia risk? evidence.nihr.ac.uk/alert/what-imp… via @NIHRresearch @CostafredaSergi @Gill_Livingston @UCLEarInstitute @UCLPsychiatry
“The evolution of AI illustrates a major quality and regulatory dilemma.” Is the FDA ready to meet the moment? jamanetwork.com/journals/jama/…
The APS2 blood test had high diagnostic accuracy for identifying Alzheimer disease among individuals w/ cognitive symptoms in primary and secondary care, providing superior performance vs the diagnostic accuracy after standard clinical evaluation. ja.ma/3AbO898
The FNIH comparison of leading Alzheimer's blood tests is now published. Tests were from C2N, Fujirebio, ALZPath, Janssen, Roche and Quanterix. Plasma %p-tau217/p-tau217 best predicted amyloid and tau PET, brain volumes, and dementia. #ENDAlz #FNIH alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…
Please re-Tweet these 7 ways to improve your #memory. (image: @BelievePHQ) #aging #health #exercise #nutrition
In adults without cognitive impairment and with low brain Aβ levels, a blood test combining p-tau217 and Aβ42/40 better predicted longitudinal changes in brain Aβ load than individual biomarkers. ja.ma/4dM62xd @biofinder_study
Another tech giant is working hard to bring something in their AI portfolio to healthcare. - foundation models for medical imaging - a healthcare data analysis platform - to build an AI documentation product geared toward nurses. healthcaredive.com/news/microsoft…
News: First wave of COVID-19 increased risk of heart attack, stroke up to three years later nih.gov/news-events/ne…
This is pretty interesting. UCL demographer’s work debunking ‘Blue Zone’ regions of exceptional lifespans wins Ig Nobel prize | IOE - Faculty of Education and Society - UCL – University College London ucl.ac.uk/ioe/news/2024/…
New large study finds COVID may increase risk of heart attacks and strokes three years after infection. Unlike other infections, the elevated heart risks from infection did not appear to diminish over time, a striking finding that the researchers say is "unique to COVID."
“The intervention comprises components such as psychoeducation, strengthening routine, light therapy, increased activity, exercise, and carer support. It is tailored to the needs of people with dementia and their relatives.”
ICYMI: New research, published in @LancetLongevity by @rapaport_penny, @Gill_Livingston & colleagues from @UCLPsychiatry, showed that a multicomponent intervention significantly enhanced sleep for those with #dementia, as well as their family carer. bit.ly/3BsjKYq
This summer, the design and baseline results paper of FINGER-NL was published. Today, Kay Deckers will present this work at the @AlzheimerEurope Conference #34AEC. Don’t miss his poster (POS1-03)!
Ramanan et al. examine the evolution of clinical phenotypes in patients diagnosed with Alzheimer's disease or FTLD, and show that behavioural and cognitive profiles of individuals with the same initial diagnosis can converge or diverge over time. tinyurl.com/4c6ymf2x
Join NIA on Oct. 16 and 17 for an upcoming webinar on leveraging adaptive technology interventions for aging and #Alzheimer’s disease and Alzheimer’s disease-related dementias. Register now: go.nia.nih.gov/4dnjiYZ
Wonderful recognition of basic and foundational discovery science on #microRNA done in a 'simple' model organism of #Celegans as a stepping stone for translational work and #NobelPrize2024.
BREAKING NEWS The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.
Happy to share one of my very favorites of our new papers: nature.com/articles/s4139… Early presence of Alzheimer's MRI patterns relate to cardiovascular, immune, and neurondocrine systems, subsequent progression relates to APOE4, tau, amyloid Led by @JunhaoWen
“The research team scrutinized the autophagy process in astrocytes and discovered that when toxic protein buildup or inflammation occurs in the brains of AD patients, astrocytes respond by inducing genes that regulate autophagy.”
New Astrocyte Target for #Alzheimers Therapy neurosciencenews.com/astrocytes-alz… via @neurosciencenew #dementia #science #neuroscience
“The treatment suppressed p-tau by 1/2 to 3/4, while lowering t-tau to the levels in wild-type mice. Dendritic arborization & spine density returned to wild-type levels as well. Neurons stopped dying, and neuronal calcium responses and neurogenesis bounced back to normal.”
A chimeric peptide that recruits protein phosphatase 1 to tau lowered phospho-tau and total tau in the brain and restored synapses in two tauopathy mouse models. #alzheimersdisease @HuazhongUST ow.ly/oASe50TFfZa
“The study provides a new perspective on the involvement of inflammatory markers in the aging process & the development of Alzheimer’s disease, implying that regulating inflammation may have a pivotal role in promoting successful aging & in the prevention … of Alzheimer’s.”
Cai et al. measure plasma inflammatory markers over 10 years in people with preclinical Alzheimer’s disease, and show that changes relative to controls in complement C3, IL-1β and IL-6 are associated with Alzheimer’s disease development. tinyurl.com/3b9kdcdh
JAMA Medical News: Study suggests the body roundness index (BRI) may be a more accurate predictor of all-cause mortality than BMI, potentially offering a more precise assessment of visceral adipose tissue & cardiometabolic risk. ja.ma/3ZT6BBV
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