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The antigen landscape in cancer is dynamic, maluable, & easily influenced by it's environment. By treating cancer cells with common drugs, we can manipulate both the IDENTITY & DENSITY of epitopes presented, & use those changes to our advantage💪 pnas.org/doi/abs/10.107… @PNASNews
Deal News: exciting new partnership between @hotspotthera and @abbvie for allosteric modulators of transcription factor IRF5... Blog on the topic from HotSpot CEO @JDMontagu: What Took So Long - How Tech Has Finally Caught Up With Transcription Factors lifescivc.com/2022/12/what-t…
lifescivc.com
What Took So Long: How Tech Has Finally Caught Up With Transcription Factors - LifeSciVC
By Gerry Harriman and Jonathan Montagu, CSO and CEO, respectively, and co-founders of HotSpot Therapeutics, as part of the From The Trenches feature of LifeSciVC. HotSpot Therapeutics today announced...
This is fabulous. ⬇️
Pele doing everything your favourite player does, first. The King of Football 👏🤴🏿
Physicists have used Google's quantum computer to send a signal through a wormhole, a shortcut in space-time first theorized by Einstein and Rosen in 1935. The landmark experiment was published today in Nature. Lots to say about it. Here's my deep dive: quantamagazine.org/physicists-cre…
Hot off the press! Do solid tumors undergo spontaneous regression? Can placebo alone produce response in solid tumors? We attempt to answer this question in this new study published @eClinicalMed : thelancet.com/journals/eclin…
How does natural microbial exposure influence ILC2 responses toward airway allergens? See our story in @NatImmunol to find out! This project is a collaboration between @Jamequistlab of @CFI_UMN and Kita lab of @MayoClinic nature.com/articles/s4159…
nature.com
Physiological microbial exposure transiently inhibits mouse lung ILC2 responses to allergens
Nature Immunology - Here the authors show that mice exposed to a variety of pathogens initially have impaired innate type 2 responses to lung allergens, but reactivity resets over time, indicating...
My Editor's Choice in @ScienceMagazine highlights work in @jclinicalinvest by @johanna_strobl, @StaryGeorg & al. Authors describe effects of #tick bites on #ImmuneSystem & develop an ex vivo model of #LymeDisease! EC: bit.ly/EC221118 Article: bit.ly/3USYkbR
Elizabeth Holmes receives sentence of 135 months in prison
If you've never seen what a CRL looks like, the FDA published one in full (p.43) in briefing documents before an Ardelyx adcomm tomorrow. (and behold the stark contrast b/t a CRL PR and an actual CRL!) fda.gov/media/163150/d… ir.ardelyx.com/news-releases/…
Dean is right. A hugely important story, barely covered cepr.net/the-crushing-h…
$REGN's Yancopoulos makes a point."We aren't the ones who are literally selling poison like high fructose corn syrup to children or polluting the earth with plastics." Those companies should help shoulder the cost of health care, he says scrip.pharmaintelligence.informa.com/articles/2022/…
The Black Death -- which killed 30-50% of the population of medieval Europe in just a few years -- is an amazing example of strong, quick natural selection that can be revealed with ancient DNA analysis nature.com/articles/s4158…
nature.com
Evolution of immune genes is associated with the Black Death
Nature - Klunk and colleagues identify signatures of natural selection imposed by Yersinia pestis and demonstrate their effect on genetic diversity and susceptibility to certain diseases in the...
What is the secret behind the success of novel ADCs? In this unmissable @Cancer_Cell commentary, the authors highlight how the increased efficacy at doses close to the MTD, rather than improved therapeutic index, makes the difference in the clinic. cell.com/cancer-cell/fu…
This is really cool/weird - a liver has survived for 108 years in total, having been transplanted from one person to another newscientist.com/article/234260…
Beautiful story on the discovery of integrins by the fantastic 2022 Lasker awardee Immunologist Tim Springer and cancer biologists Erkki Ruoslahti & Richard Hynes. Incredible how many transformative discoveries were made during my adult life. cell.com/cell/fulltext/…
A century ago, height helped to reconcile Mendel’s laws with the inheritance of complex traits. Now, @LoicYengo et al made it the first trait to have all its common genetic effects captured, which predict better than the parental average. This is major. - nature.com/articles/s4158…
Late-stage data unveiled on Thursday showed GSK's respiratory syncytial virus (RSV) vaccine was 82.6% effective in a keenly-watched late-stage study involving older adults. reut.rs/3g42E8I
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