Machine Learning 4 Oncology
@ml4onc
Team of researchers, students, and clinicians using machine learning to help people with cancer | PI: Rob Grant
New research out today: ML can predict future symptoms during cancer treatment from EHR data. Congrats to Noke for his first paper during his PhD.👏 Great to collaborate with @PM_CDI and the rest of the team. @JCOCCI_ASCO @PMResearch_UHN. ascopubs.org/doi/10.1200/CC…
PASS-01:ph II mFFX v GnP;#PDAC denovo met ds; excl gBRCA/PALB2 ➡️no clinically sig diff GnP v mFFX ➡️basal-like poor OS-mPFS on mFFX 3 mths ➡️54% receive 2nd line; mOS<6mths ➡️PDOs/ctDNA to come @AmberHabowski 1st-line biomarkers essential-RAS &🤞subtype doi.org/10.1200/JCO-25…
Terrific preprint by @hartjackson using imaging mass cytometry (IMC) & matched genomics for building multimodality prediction models: Integrated spatial proteomics of human PDAC uncovers an expanded tumour–immune– stroma spectrum with genomic associations biorxiv.org/content/10.110…
Final COMPASS trial data advanced #PDAC ➡️268 WGS& 253RNA-seq ➡️basal-like& hi GRIm-S ⬇️OS, both unique TME inc CD8 variation,NB primaries vs mets ➡️LTS :HRD, KRAS WT ➡️KRAS major enriches basal, >type II DM ➡️LAPC≠intact SMAD4 ➡️47% receive 2nd line tx nature.com/articles/s4146…
Study demonstrated cisplatin treatment was followed by a predictable decrease in the estimated glomerular filtration rate (eGFR), placing patients with a lower baseline eGFR at the highest risk of CKD. ja.ma/41eBxMU
Sharing our research in @JAMAOnc predicting chronic kidney disease after cisplatin treatment. Thanks to @KevinJCHe, @onconeph, @MarzyehGhassemi, and the rest of the team, as well as @ICESOntario, @PMResearch_UHN, @thePMCF, and @OICR_news for their support jamanetwork.com/journals/jamao…
Congrats to PhD student Noke's team for winning the @UofT_TCAIREM Health Datathon! mailchi.mp/utoronto/tcair…
Inspiring to see the international community come together at the PRECEDE Annual Meeting to figure out how to prevent pancreatic cancer! Our screening program at @pmcancercentre contributes to this important initiative
The @PrecedeStudy, the nation’s largest pancreatic cancer early detection initiative, is holding its annual meeting in San Diego on Nov 7-8. We aim to improve early detection and increase the 5-year survival rate to 50% in the next decade! bit.ly/3ApP5Lp
The @PrecedeStudy, the nation’s largest pancreatic cancer early detection initiative, is holding its annual meeting in San Diego on Nov 7-8. We aim to improve early detection and increase the 5-year survival rate to 50% in the next decade! bit.ly/3ApP5Lp
Congrats to David, Kevin (co-supervised with @bhaibeka), and Yuanchang (with PanCuRx at @oicr_news and @LabNotta) ! And huge thank you to MOHCCN for the support!
The winners are: 📸🔼 Julia Nguyen (UHN), Yuanchang Fang (UHN), Dr. David Henault (UHN), Xin Kevin Wang (UHN), Ali Khajegili Mirabadi (UBC), Xindi Zhang (OICR) 📸🔽Jorge Pinzón-Mejía (Dal), Hyojin Song (UCalgary), Caralyn Reisle (BC Cancer), Andrew Garvin (Queen's University)
Thank you to TD Ready Commitment. We are honoured and appreciate the responsibility that comes with this incredible gift. Our team is already hard at work to realize our vision of using AI to improve cancer care.
Thank you to TD Ready Commitment for their generous gift. You’re making it possible for Dr. Robert Grant and his team to improve cancer patients’ lives with AIM2REDUCE, an AI-based early warning system for patients who would be more likely to face adverse cancer events.
Great summary of our recent study on the performance of LLMs on medical oncology exams in @JAMANetworkOpen. Amazing effort from @IanHirsch3 and the team! Thanks to @thePMCF @pmcancercentre @PM_CDI @OICR_news @ICESOntario
1/ Large Language Models (LLMs) contain extensive medical knowledge despite not being specifically trained for it; but, their performance on standardized tests across various subspecialties is inconsistent.
PASS-01 trial #PDAC #ASCO24 ➡️rand ph2 mFFX vs.GnP ➡️WGS/RNA/PDO/CTCs/ctDNA ✅PP PFS 5.5 (GnP) vs. 4.0mths (mFFX) ➡️PP ❌gBRCA/PALB2 >KRASWT in GnP ➡️MTB directed 2nd line ➡️ GnP remains a backbone for drug dvp ➡️basal-like unmet need Proud @AmberHabowski as translational leads
🌞Great sunny day in Toronto, just starting the Cholangiocarcinoma in PSC Symposium at @UHN 🤩Looking forward to great talks and discussion on new strategies for prevention and treatment of cancer in PSC @myESMO @EASLedu @ILCAnews @curecc #livertwitter @sapisochin
REACT is an AI chatbot to help healthcare workers triage care for patients with cancer. Looking forward to Robert Grant @pmcancercentre @UHN_Research pitching his innovation at Falcons' Fortunes this Thursday. #FF2024 facit.ca/falcons-fortun…
🔥Great summary by @KevinJCHe of his study! 👏👏
1/ Palliative care (PC) can significantly improve outcomes for advanced cancer patients. But limited capacity often delays or prevents access. Our latest study from Ontario, 🇨🇦, explores using machine learning to address this gap. @JCO_ASCO ascopubs.org/doi/10.1200/JC…
🎉 Welcome to the team Robert Grant! Dr. Grant's research focuses on using machine and deep learning to integrate multimodal data to improve clinical decision-making for people with cancer ices.on.ca/ices-scientist…
A prognostic #MachineLearning system can promote early palliative care. ➡️ brnw.ch/21wHciH #PallOnc @ml4onc
🔥World Cholangiocarcinoma (CCA) Day 2024🔥 #WorldCCADay 💪The multidisciplinary TEAM in Toronto 🇨🇦 is growing😅 👉Dedicated to fight this devastating disease 🙏to all who support! #BeClearOnCCA @myESMO @EASLedu @ILCAnews @curecca #livertwitter @UHN @UHN_Research @PMResearch_UHN…
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