Lihan Zhang
@npevolution
The Zhang lab studies (bio)chemical diversity of natural products and synthetic biology applications at Westlake University.
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We developed a prediction tool for the substrate amino acid of adenylation domains. Hope this can be helpful for NRPS analysis! nrpstransformer.cn
nrpstransformer.cn
NRPS Transformer
NRPS Transformer
NRPStransformer, an Accurate Adenylation Domain Specificity Prediction Algorithm for Genome Mining of Nonribosomal Peptides | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/ja…
pubs.acs.org
NRPStransformer, an Accurate Adenylation Domain Specificity Prediction Algorithm for Genome Mining...
Nonribosomal peptides serve as pivotal sources for drug discovery. Accurate prediction of the substrate specificity of adenylation domains in nonribosomal peptide synthetases is crucial for genome...
And appreciate this beautiful News&Views by Dr. Grininger for our works. nature.com/articles/s4158…
Breakthrough in Enzyme Engineering! Researchers from Westlake University published two back-to-back papers in Nature Chemical Biology, unveiling a novel approach to enzyme engineering that could revolutionize the way we manufacture complex chemical molecules.…
Out today at @ScienceMagazine - giant PKZILLA proteins spew huge polyketide marine toxins, just like #Godzilla! Witnessed by @photocyte & @VikShende at @Scripps_Ocean science.org/doi/10.1126/sc…
Excited to share our work on stereochemical prediction of cis-AT modular PKS. We found the KR motif-based prediction is affected by the module architecture and taxonomic origin of the PKS, and provided an update in stereochemical prediction. beilstein-journals.org/bjoc/articles/…
We are excited to finally publish the unprecedented biosynthetic origins of enediyne natural products: iodinated polyynes! This transformative discovery is a huge milestone for these clinical antitumor antibiotics. @Kalkreuter @guichun98 @nchembio nature.com/articles/s4158…
Move over titin... introducing PKZILLA as the largest protein in life that makes one the largest nonpolymeric compounds in biology, the marine polyether toxin prymnesin. Congrats to @photocyte & @VikShende and rest of team! biorxiv.org/content/10.110…
Interesting PKS and C domain reaction!
Our recent work published on @NatureSynthesis nature.com/articles/s4416…
nature.com
Discovery and biosynthetic pathway analysis of cyclopentane–β-lactone globilactone A
Nature Synthesis - β-Lactone-containing natural products are rare. Now, a polyketide with a unique cyclopentane–β-lactone skeleton is reported. The key enzymes identified for the...
Glad that our review has been selected as a VIP. Hope our bioinformatics-driven approach can be helpful in providing a clearer picture of T2PKS biosynthesis and the product molecules.
Type II Polyketide Synthases: A Bioinformatics-Driven Approach (Zhang and Xie) @npevolution onlinelibrary.wiley.com/doi/10.1002/cb…
Wishing you a wonderful spring for the new academic year! #WestlakeSeasons #WestlakeYunguCampus
See how Yajie Wang’s synthetic biology and protein engineering team at Westlake University’s WangSynbio Lab is exploring the use of engineered enzymes and modified microbes to create a healthier, cleaner and more sustainable world. #WomenInScience #WomensHistoryMonth #HerWestlake
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