Pediatric Nephrology
@Ped_Neph
Original clinical research and reviews on all aspects of acute & chronic diseases affecting kidney function in children. Official journal of IPNA @IPNA_PedNeph
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Children on kidney replacement therapy face complications resulting in recurrent hospitalizations. Read this Original Article comparing hospitalization rates & causes between children treated w/chronic peritoneal dialysis & hemodialysis. #OpenAccess link.springer.com/article/10.100…
Nephrotic syndrome (NS) is characterized by increased glomerular permeability resulting from podocyte injury & disruption of the glomerular filtration barrier. Read this Research Letter about neuraminidase activity in pediatric NS. #OpenAccess link.springer.com/article/10.100…
Children & adolescents on hemodialysis typically engage in substantially less physical activity than their healthy peers. Read this Research Letter on exergaming to promote physical activity in children & adolescents during hemodialysis. #OpenAccess link.springer.com/article/10.100…
Limited data exist on the use of novel iron therapies in children w/CKD. Read this Original Article comparing iron polymaltose complex & liposomal iron in pediatric patients w/CKD & iron deficiency anemia. #OpenAccess link.springer.com/article/10.100…
Hyperkalemia following nephrectomies in children is a poorly studied, life-threatening complication. Read this Original Article on frequency & risk factors for hyperkalemia in pediatric patients who underwent nephrectomies resulting in an anephric state. link.springer.com/article/10.100…
APOL1 high-risk variants predispose to CKD in people of African genetic ancestry due to podocyte toxicity; CAKUT have variable outcomes driven by podocyte injury. Read this Original Article on APOL1 kidney risk variants & outcomes in children w/CAKUT. link.springer.com/article/10.100…
Accurate volume assessment is essential in the management of children on dialysis. Read this Original Article on N-terminal pro B-type natriuretic peptide levels in a pediatric hemodialysis cohort. link.springer.com/article/10.100…
Exploring the role & scope of microbiota-targeted therapies in pediatric CKD is important. Read this Review of gut-targeted therapies for restoring a balanced gut microbiota, & their effects on clinical outcomes in pediatric CKD. Free access this month. bit.ly/44R2Nmt
Recent technologic advances in neonatal dialysis have changed current dialysis practices. Read this Original Article on dialysis modality & mortality of the Contemporary Infant and Neonatal Dialysis (COINED) Cohort. #OpenAccess link.springer.com/article/10.100…
AKI is a frequent & severe condition in hospitalized children, leading to significant morbidity, mortality, & long-term risk of CKD. Read this Review of the gut–kidney axis in pediatric AKI: pathophysiological mechanisms & therapeutic frontiers. link.springer.com/article/10.100…
Pediatric nephrology patients have high rates of treatment nonadherence, increasing their risk for poor health outcomes. Read this Ed Review of local environment, socioeconomic status, & health literacy: key modifiers of adherence in pediatric nephrology. link.springer.com/article/10.100…
Ravulizumab drug monitoring has not been explored for mor maintenance therapy in patients w/complement-mediated (atypical) hemolytic uremic syndrome (aHUS). Read this Original Article on ravulizumab trough levels in aHUS in remission. link.springer.com/article/10.100…
Post-kidney transplant arterial hypertension (HTN) is a common complication after kidney transplant. Read this Original Article on circadian BP patterns in kidney transplant recipients assessed by ambulatory BP monitoring. link.springer.com/article/10.100…
Differentiating STEC-HUS from aHUS can be challenging due to overlapping clinical presentations. Confirming STEC infection is crucial to guide treatment. Read this Original Article on the role of serology in STEC detection. link.springer.com/article/10.100…
The current criteria modified from KDIGO for neonatal AKI underestimate its prevalence. Read this Original Article on establishing a reference range for serum creatinine in the neonatal population & re-defining neonatal AKI. link.springer.com/article/10.100…
Lupus nephritis (LN) is a severe manifestation of systemic lupus erythematosus, affecting up to 1/3 of pediatric SLE patients. Read this Systematic Rev /Meta-analysis of efficacy of mycophenolate mofetil vs. cyclophosphamide in mgmt of childhood-onset LN. link.springer.com/article/10.100…
Early detection of ophthalmological & kidney complications of hypertension in children & adolescents may help w/prophylaxis & prevent irreversible organ damage. Read this Original Article on retinal vascular density in children w/HT. #OpenAccess link.springer.com/article/10.100…
Lesch–Nyhan syndrome is a rare X-linked recessive disorder. It is characterized by severe neurological manifestations & self-injurious behavior. Kidney involvement is an underrecognized but important aspect. Read these Clinical Insights for more. link.springer.com/article/10.100…
Familial hypocalciuric hypercalcemia (FHH) is a rare genetic disorder of calcium regulation. FHH type 3 (FHH3) is caused by pathogenic variants in AP2S1. Read these Clinical Insights on cinacalcet therapy in a symptomatic 11-yr-old girl w/FHH3. link.springer.com/article/10.100…
Adolescent primary hypertension is associated w/decreased neurocognitive performance, suggesting early target organ damage to the brain. Read this Original Article on brain magnetic resonance imaging in adolescents w/primary hypertension. link.springer.com/article/10.100…
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