Tor Erik Rusten
@rustenlab
Cancer Researcher. Associate prof. at the University of Oslo, PI at The Norwegian Radium Hospital and CanCell Centre of Excellence. Tweets are my own.
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We are very proud to share our work #Autophagy-mediated wasting of host tissues provides amino acids and sugars that contribute to tumor biomass. Great collaboration with @GottliebLab, @RusanLab, @SchoborgLab, @HopeJahren, Jasperlab & @CanCell_UiO members embopress.org/doi/10.15252/e…
Yea @RogerLiang9 rock star
Where do cancers start? In the liver, not all cells are the same. The liver is divided into 3 “zones,” and each specializes in different metabolic tasks. We show in @Science that where a mutation occurs in a liver lobule can determine a cell’s fate. science.org/doi/10.1126/sc… (1/9)
Online Now: Metabolic environment-driven remodeling of mitochondrial ribosomes regulates translation and biogenesis dlvr.it/TP6Tcj
Great story by White lab member @CararoLopes @RutgersCancer @LudwigCancer @Princeton showing that mitochondrial respiration enables serine synthesis for the growth of lung cancer! Defective mitos cause dependence on dietary serine for tumor growth! rdcu.be/eAUIx
Online today in @Nature - our latest study led by superstar postdoc @GillesRademaker detailing the role of PSCK9 in driving sterol dependent metastatic organ choice in pancreatic cancer nature.com/articles/s4158… full text available here 👉 rdcu.be/em0VG and thread 👇
One year ago, I reserved and paid a deposit on two rooms at @Hyatt Place Princeton through @hotelsdotcom for my daughter's graduation. One day before arrival I learn that @hyatt canceled one room without explanation or recourse. Now am scrambling to find housing. Buyers beware.
Everything you've ever wanted to know about #Ferroptosis in Health and Disease! Massive review from many in the field. Happy to have contributed and huge thank you for the leadership from Carsten Berndt / Marcus Conrad @Conrad_Lab. 🙂 doi.org/10.1016/j.redo…
Sharing our latest review on peptide hormones by Laetitia Coassolo @Laeti67202 and Amanda Wiggenhorn @AmandaWigg_ in Trends in Biochemical Sciences @TrendsBiochem @StanfordPath Free full text: sciencedirect.com/science/articl…
Lactate controls cancer stemness and plasticity through epigenetic regulation dlvr.it/TJwtQM
We are thrilled to announce the appointment of Alec C. Kimmelman, MD, PhD, as the next Chief Executive Officer at @nyulangone and Dean of @nyugrossman effective September 1, 2025. Learn more: nyulangone.org/news/nyu-lango…
KnockTF: a comprehensive human gene expression profile database with knockdown/knockout of transcription factors Now KnockTF 2.0 👤🐭🌱🌽 >1400 transcriptomes ~800 TF/TcoF licpathway.net/KnockTF/index.… Go to "Search" for your TF "Quick Search" does not work @NAR_Open 2020…
Lactate homeostasis is maintained through regulation of glycolysis and lipolysis dlvr.it/TJMzm9
Congrats @realTonyHui
New! Online now: An organism-level quantitative flux model of energy metabolism in mice dlvr.it/TJ5KPX
Munich 1938, Europe’s leaders made an agreement that Adolf Hitler could take parts of Czechoslovakia in exchange for a promise that Germany would not engage in further acts of war. Czechoslovakia was not involved in negotiations but had to accept the outcome.
Top 5 advances in medicine this week (🧵) 1. The first-in-human use of iPSC-derived CAR-NK cells
A rapid chemical reprogramming system to generate human pluripotent stem cells nature.com/articles/s4158… nature.com/articles/s4158…
Body and brain must communicate to adapt behavior efficiently. Using the fly, we discover a bidirectional pathway between the fat body and the brain and show that fat body-produced dopamine changes food preference.
A Bidirectional Brain-Fat Body Axis for Pathogen Avoidance biorxiv.org/cgi/content/sh… #biorxiv_neursci
GLP-1 receptor agonists, which are effective for weight loss, can cause substantial muscle loss. A Comment in @TheLancetEndo discusses the effects of GLP-1 receptor agonists on skeletal muscle mass: hubs.li/Q02WgC490
New preprint! Our latest study identifying how MHC-I is captured by autophagy and targeted for degradation in #PDAC - It all happens at the ER ! Congrats to co-first authors @marineberquez @li_alexl & Matthew Luy. Details below 👇 biorxiv.org/content/10.110…
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