Tae Hoon Kim
@taehoonkim
Professor - Scientist - Inventor http://e-rna.com
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New from me, in @Nature: Mathematicians put AI model AlphaProof to the test. A solicited News & Views article about @GoogleDeepMind AlphaProof that was an absolute joy to write! rdcu.be/ePz4Q
Synthetic α-synuclein fibrils replicate in mice causing MSA-like pathology nature.com/articles/s4158…
“Stop trying to be happy — and start figuring out how to make other people happy.” A 6-year research project found a surprisingly simple route to happiness apple.news/AAq3yJUNFRCGbp…
Another CRISPR screen, another discovery! Congrats to Elena De Cecco et al. for discovering a completely unexpected role for BMP signaling in prion uptake, the 1st step of prion propagation. No way to find this except by massive forward genetics. biorxiv.org/content/10.110…
Everywhere it seems impossible to keep up on science and technology for a normal person. Some who are enabled are building rockets while many of us are still tinkering with our bicycles. nature.com/articles/s4158… cell.com/cell/fulltext/…
Repair of DNA double-strand breaks leaves heritable impairment to genome function science.org/doi/10.1126/sc…
Please read the thoughtful Blog that @cshperspectives and the @openrxiv wrote on integrating pre-prints with AI review openrxiv.org/enabling-revie…
IT'S HAPPENING! 💥 I'm psyched to launch the collaboration between @qedScience & @openrxiv @biorxivpreprint! Let's go back to concentrating on making discoveries, and not on “getting published”, because it’s not going to matter soon, when feedback & evaluation are detached from…
Beautiful piece by James Somers @jsomers probing the question "What is thought?" I enjoyed it on many levels--for learning other neuroscientists' take on LLMS, for the great book recommendations, for the framing of the problem in my favorite form--the story of an individual…
Enjoyed reading the recent paper from gnomAD team on the modifiers of penetrance of clinically-relevant variants in 800k individuals in the gnomAD database. One example highlighted in the paper is extremely fascinating! It's a beautiful example of a loss of function (LOF)…
What an amazing paper from the Bonasio lab! Domesticated retroviral proteins and RNA-modifying enzymes that regulate RNA loading into and transportation via extracellular vesicles. The pseudouridine synthase PUS1 is a key determinant of RNA trafficking, and that its catalytic…
"The elite persona is defined by a studied obliviousness to status-seeking. You’re not supposed to act like you’re chasing influence. You’re supposed to act like you just happened to end up there while pursuing truth or service." robkhenderson.com/p/experts-and-…
The neuron–astrocyte metabolic unit as a cornerstone of brain energy metabolism in health and disease go.nature.com/47NI2Ke
In @Nature: Using AI and other cutting-edge techniques, the Klinge lab has captured the first near-continuous "molecular movie" of ribosome formation—revealing, frame by frame, how cells build the protein factories that make life possible. More here: rockefeller.edu/news/38513-maj…
I am happy to share that LocusCompare2 has been published in Nature Genetics @NatureGenet. This study is led by two outstanding PhD students Fei Liu and Junbin Gao. Paper: rdcu.be/eMTU7 Website: locuscompare2.com 1/9
Cool mechanism: C. elegans telomerase RNA hitchhikes on introns of germline–up-regulated genes science.org/doi/10.1126/sc…
For obvious reasons, I've become fascinated with retrotransposons. So we (Alex Whiteley and I) wrote an article now out in @NeuroCellPress on how we think retrotransposons influence brain function and health! sciencedirect.com/science/articl…
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