tasvinder_singh's profile picture. Mitochondria-savvy PhD exploring cancer and tumour-immune metabolism; bridging cancer cell heterogeneity with T cell bioenergetics in the TME.

Tashvinder Singh

@tasvinder_singh

Mitochondria-savvy PhD exploring cancer and tumour-immune metabolism; bridging cancer cell heterogeneity with T cell bioenergetics in the TME.

Tashvinder Singh reposted

it is now unequivocally clear that mitochondria play a multitude of cellular functions beyond energy production. We now appreciate that mitochondria are essential organelles directing the fate and function of innate and adaptive immune cells. Mitochondria are vital for modulating…

Madam_Mito's tweet image. it is now unequivocally clear that mitochondria play a multitude of cellular functions beyond energy production.
We now appreciate that mitochondria are essential organelles directing the fate and function of innate and adaptive immune cells.
Mitochondria are vital for modulating…

Alterations in mitochondrial morphology as a key driver of immunity and host defence | EMBO reports embopress.org/doi/full/10.15…



Tashvinder Singh reposted

The bioelectric aspects of mitochondria are of particular relevance on all levels of organization of an organism. Mitochondria not only stand out because of their high membrane potential but also since they can form mitochondrial networks that can be electrically coupled.…

Madam_Mito's tweet image. The bioelectric aspects of mitochondria are of particular relevance on all levels of organization of an organism. 

Mitochondria not only stand out because of their high membrane potential but also since they can form mitochondrial networks that can be electrically coupled.…

Tashvinder Singh reposted

Mitochondria near the nucleus (i.e., in the perinuclear region) have generally a lower membrane potential than in the periphery of the cell. There is a great heterogeneity with respect to morphology and the metabolic state (indicated by the MMP) The mitochondrial membrane…

Madam_Mito's tweet image. Mitochondria near the nucleus (i.e., in the perinuclear region) have generally a lower membrane potential than in the periphery of the cell.
There is a great heterogeneity with respect to morphology and the metabolic state (indicated by the MMP) The mitochondrial membrane…

The bioelectric aspects of mitochondria are of particular relevance on all levels of organization of an organism. Mitochondria not only stand out because of their high membrane potential but also since they can form mitochondrial networks that can be electrically coupled.…

Madam_Mito's tweet image. The bioelectric aspects of mitochondria are of particular relevance on all levels of organization of an organism. 

Mitochondria not only stand out because of their high membrane potential but also since they can form mitochondrial networks that can be electrically coupled.…


Tashvinder Singh reposted

The ANRF grant process should be made fully transparent. The criteria of judgment should be spelled out beforehand, and we should be able to view the proposals that were rewarded.


Tashvinder Singh reposted

We are in the Era of Nepo-docs… Professional Competence of an applicant with 15+ new species is “Moderate”.. A big ugly joke…. #anrf #npdf

Hari_SHM's tweet image. We are in the Era of Nepo-docs…

Professional Competence of an applicant with 15+ new species is “Moderate”.. 

A big ugly joke….

#anrf #npdf

Tashvinder Singh reposted

🧠 Normal brain: win → dopamine spikes near miss → dopamine flat 🎰 Gambler’s brain: win → dopamine spikes near miss → dopamine spikes HIGHER This is "loss-chasing" = addiction hijacks the ventral striatum so that uncertainty and loss (not reward) create a chase.

KeithSakata's tweet image. 🧠 Normal brain: 
win → dopamine spikes 
near miss → dopamine flat

🎰 Gambler’s brain: 
win → dopamine spikes
near miss → dopamine spikes HIGHER

This is "loss-chasing" = addiction hijacks the ventral striatum so that uncertainty and loss (not reward) create a chase.

Tashvinder Singh reposted

Khalsa Aid Tennessee provided  backpacks and stationary kits collaborating with Beyond Education organisation to almost 100 kids going back to school.

KhalsaAidUSA's tweet image. Khalsa Aid Tennessee provided  backpacks and stationary kits collaborating with Beyond Education organisation to almost 100 kids going back to school.
KhalsaAidUSA's tweet image. Khalsa Aid Tennessee provided  backpacks and stationary kits collaborating with Beyond Education organisation to almost 100 kids going back to school.
KhalsaAidUSA's tweet image. Khalsa Aid Tennessee provided  backpacks and stationary kits collaborating with Beyond Education organisation to almost 100 kids going back to school.

Tashvinder Singh reposted

In Uttarkashi, one of our amazing supporters met the Khalsa Aid team and joined hands in distributing relief to flood-hit families. #Uttarkashi #HumanityFirst #khalsaaidindia #khalsaaid #uttarakhand #floodrelief #flashfloods #uttarkashiflashfloods


Tashvinder Singh reposted

A white couple was brutaIIy beaten at a jazz festival by a black "teen mob" in Cincinnati yesterday. 0 national coverage.

EndWokeness's tweet image. A white couple was brutaIIy beaten at a jazz festival by a black "teen mob" in Cincinnati yesterday.

0 national coverage.
EndWokeness's tweet image. A white couple was brutaIIy beaten at a jazz festival by a black "teen mob" in Cincinnati yesterday.

0 national coverage.

Tashvinder Singh reposted

The majority of people don't want this... you do realize that, right? You're catering to the world of insecure and severely introverted/depressed people who can't manage being in public with other individuals. This is terrible for society.


Tashvinder Singh reposted

Even the most advanced AI can't solve these 😭


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