Wei Zhou
@weizhouw
I develop and apply statistical and computational tools to study genetics of human diseases and traits using biobanks. Assistant Investigator @CGM_MGH
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Excited to share our latest preprint introducing SAIGE-QTL, a powerful tool for single-cell eQTL analysis! Check it out here: medrxiv.org/content/10.110… #eQTL #scRNAseq #genomics (1/9)
Would you believe me if I told you that a single variant in a non-coding RNA explains ~0.5% of all undiagnosed individuals with neurodevelopmental disorders (NDD) in @GenomicsEngland ??? I didn’t initially either, but here is the story of RNU4-2 🧵1/9
Thrilled to share our latest discovery on a spliceosomal snRNA gene causing neurodevelopmental disorders: medrxiv.org/content/10.110… Thank you to everyone who contributed; it’s been a phenomenal effort to collaborate with clinicians and researchers for what would help many families!
Excited to share our work in print at @AJHGNews using variant call data to estimate DNA contamination. As our sample sizes get into the millions of genomes, we need methods like this to efficiently process and quality control the data authors.elsevier.com/a/1i8PAgeX6LB%…
Out today @Nature – our analysis of the influences of common nuclear DNA variation on mitochondrial DNA copy number and heteroplasmy across >250,000 people across two biobanks! disq.us/t/4ibyjjo
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