#n6amt1 search results
Welcome to read and share this paper @MediPharma_MDPI "Cross-Reactivity of #N6AMT1 #Antibodies with Aurora Kinase A: An Example of Antibody-Specific Non-Specificity" mdpi.com/2073-4468/13/2…
Stressed mitochondrial RNA granules from our recent work on the cover of @PNASNews! A photo by E. Recazens illustrating our new story led by M. Foged on the cytosolic control of mitochondrial RNA processing and innate immunity by #N6AMT1. #mitochondria #dsRNA @FBM_UNIL
In summary, our work identifies a novel mechanism involved in #mitochondrial_biogenesis from 𝗼𝘂𝘁𝘀𝗶𝗱𝗲 mitochondria. It is based on: N6AMT1 > TRMT10C/PRORP synthesis > mtRNA processing > OXPHOS Could that explain how #N6AMT1 participates to #cancerproliferation? 8/9
In #N6AMT1-depleted cells: ❌#mitochondrial_translation ❌#OXPHOS ⏫unprocessed #mtRNA and #dsRNA - a very immunogenic molecule ‼️#interferon and #innate_immunity signaling are triggered 🦠 7/9
We found #N6AMT1 affects cytosolic translation, in particular enzymes of the #mtRNA_metabolism machinery. We confirmed this using #mePROD and #mePRODmt @MuenchLab Strikingly, two proteins were common across all three technologies: #TRMT10C (MRPP1) and #PRORP (MRPP3). 5/9
Our story on a novel pathway that controls #mitochondria from the 𝐜𝐲𝐭𝐨𝐬𝐨𝐥 and influences #immunity is now peer-reviewed and available at @PNASNews! pnas.org/doi/10.1073/pn… By M. Foged @DIB_UNIL @FBM_UNIL @MuenchLab @VamsiMootha #N6AMT1 #mtDNA #RNA_processing A recap 🧵
In summary, our work identifies a novel mechanism involved in #mitochondrial_biogenesis from 𝗼𝘂𝘁𝘀𝗶𝗱𝗲 mitochondria. It is based on: N6AMT1 > TRMT10C/PRORP synthesis > mtRNA processing > OXPHOS Could that explain how #N6AMT1 participates to #cancer proliferation? 9/10
In #N6AMT1-depleted cells: ❌ #mitochondrial_translation ❌#OXPHOS ⏫unprocessed #mtRNA and #dsRNA - a very immunogenic molecule ‼️#interferon and #innate_immunity signaling are triggered 🦠 8/10
We found #N6AMT1 affects cytosolic translation, in particular enzymes of the #mtRNA_metabolism machinery. We confirmed this using #mePROD and #mePRODmt @MuenchLab Strikingly, two proteins were common across all three technologies: #TRMT10C (MRPP1) and #PRORP (MRPP3). 5/10
Our story on a novel pathway that controls #mitochondria from the 𝐜𝐲𝐭𝐨𝐬𝐨𝐥 and influences #immunity is now peer-reviewed and available at @PNASNews! pnas.org/doi/10.1073/pn… By M. Foged @DIB_UNIL @FBM_UNIL @MuenchLab @VamsiMootha #N6AMT1 #mtDNA #RNA_processing A recap 🧵
Stressed mitochondrial RNA granules from our recent work on the cover of @PNASNews! A photo by E. Recazens illustrating our new story led by M. Foged on the cytosolic control of mitochondrial RNA processing and innate immunity by #N6AMT1. #mitochondria #dsRNA @FBM_UNIL
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