#psmaddition search results

A reflection of key prostate studies at @myESMO #ESMO25, starting with #PSMAddition. First positive study of a radioligand in mHSPC, with significant PFS improvement (HR 0.72), favourable safety profile. Complete response rates notably higher, 57% and 42% 1/4

Kenrickng1's tweet image. A reflection of key prostate studies at @myESMO #ESMO25, starting with #PSMAddition. First positive study of a radioligand in mHSPC, with significant PFS improvement (HR 0.72), favourable safety profile. Complete response rates notably higher, 57% and 42% 1/4

🎯Patient individualisation is a Must! For Patient selection and follow up! The aim is that the Patient live longer BUT also BETTER 🥇 #qualityoflife #PSMAddition #ESMO25 #prostatacancer @DrScottTagawa

UroTeragLATAM's tweet image. 🎯Patient individualisation is a Must! For Patient selection and follow up! The aim is that the Patient live longer BUT also BETTER 🥇 #qualityoflife #PSMAddition #ESMO25 #prostatacancer @DrScottTagawa
UroTeragLATAM's tweet image. 🎯Patient individualisation is a Must! For Patient selection and follow up! The aim is that the Patient live longer BUT also BETTER 🥇 #qualityoflife #PSMAddition #ESMO25 #prostatacancer @DrScottTagawa
UroTeragLATAM's tweet image. 🎯Patient individualisation is a Must! For Patient selection and follow up! The aim is that the Patient live longer BUT also BETTER 🥇 #qualityoflife #PSMAddition #ESMO25 #prostatacancer @DrScottTagawa

#PSMAddition (LBA6, #ESMO25 )The phase 3 PSMAddition trial brings radioligand therapy into the mHSPC setting. In 1,144 PSMA+ patients, adding [^177Lu]Lu-PSMA-617 to ADT + ARPI significantly improved rPFS (HR 0.72, p = 0.002) ✅ 85% completed all 6 Lu-PSMA cycles.

docjavip's tweet image. #PSMAddition (LBA6, #ESMO25 )The phase 3 PSMAddition trial brings radioligand therapy into the mHSPC setting.

In 1,144 PSMA+ patients, adding [^177Lu]Lu-PSMA-617 to ADT + ARPI significantly improved rPFS (HR 0.72, p = 0.002)

✅ 85% completed all 6 Lu-PSMA cycles.
docjavip's tweet image. #PSMAddition (LBA6, #ESMO25 )The phase 3 PSMAddition trial brings radioligand therapy into the mHSPC setting.

In 1,144 PSMA+ patients, adding [^177Lu]Lu-PSMA-617 to ADT + ARPI significantly improved rPFS (HR 0.72, p = 0.002)

✅ 85% completed all 6 Lu-PSMA cycles.

@AzadOncology delivered one of the most thorough and balanced discussions I’ve ever heard. Excellent summary ⬇️. Congratulations to @DrScottTagawa on an excellent presentation and to the #PSMAddition investigators for addressing the role of Lu-PSMA-617 in mHSPC. #ESMO25

AmandaNizamMD's tweet image. @AzadOncology delivered one of the most thorough and balanced discussions I’ve ever heard. Excellent summary ⬇️. 

Congratulations to @DrScottTagawa on an excellent presentation and to the #PSMAddition investigators for addressing the role of Lu-PSMA-617 in mHSPC. #ESMO25…

Congrats to @DrScottTagawa on his presentation of PSMA-Addition, and to @AzadOncology on a very thoughtful discussion. Compelling data data but agree with Azad’s take that questions remain. Excellent points around the possibility of a “sink effect” & risks of secondary…

montypal's tweet image. Congrats to @DrScottTagawa on his presentation of PSMA-Addition, and to @AzadOncology on a very thoughtful discussion. Compelling data data but agree with Azad’s take that questions remain. Excellent points around the possibility of a “sink effect” & risks of secondary…
montypal's tweet image. Congrats to @DrScottTagawa on his presentation of PSMA-Addition, and to @AzadOncology on a very thoughtful discussion. Compelling data data but agree with Azad’s take that questions remain. Excellent points around the possibility of a “sink effect” & risks of secondary…


Breakthrough in #PSMAddition: 177Lu-PSMA-617+ ADT+ARPi significant improve rPFS in patients with PSMA-pos mHSPC. Data reveals an HR of 0.27. Adverse event profile remained within expected for #Lu177PSMA treatment with no unexpected increases when combined with ADT+ARPI #ESMO25

UroTeragLATAM's tweet image. Breakthrough in #PSMAddition: 177Lu-PSMA-617+ ADT+ARPi significant improve rPFS in patients with PSMA-pos mHSPC. Data reveals an HR of 0.27. Adverse event profile remained within expected for #Lu177PSMA treatment with no unexpected increases when combined with ADT+ARPI #ESMO25
UroTeragLATAM's tweet image. Breakthrough in #PSMAddition: 177Lu-PSMA-617+ ADT+ARPi significant improve rPFS in patients with PSMA-pos mHSPC. Data reveals an HR of 0.27. Adverse event profile remained within expected for #Lu177PSMA treatment with no unexpected increases when combined with ADT+ARPI #ESMO25
UroTeragLATAM's tweet image. Breakthrough in #PSMAddition: 177Lu-PSMA-617+ ADT+ARPi significant improve rPFS in patients with PSMA-pos mHSPC. Data reveals an HR of 0.27. Adverse event profile remained within expected for #Lu177PSMA treatment with no unexpected increases when combined with ADT+ARPI #ESMO25

5 GU studies that we focused on during our conference highlight discussion with @bergsa83 from #ESMO25: ✅ #PSMAddition by @DrScottTagawa#CAPItello281#POTOMAC#Keynote905/EV303 ✅ #IMvigor011 by @tompowles1 #gusm #OncTwitter #MedTwitter @OncUpdates

OncBrothers's tweet image. 5 GU studies that we focused on during our conference highlight discussion with @bergsa83 from #ESMO25: 

✅ #PSMAddition by @DrScottTagawa 
✅ #CAPItello281
✅ #POTOMAC
✅ #Keynote905/EV303
✅ #IMvigor011 by @tompowles1 

#gusm #OncTwitter #MedTwitter @OncUpdates

GU Malignancy Highlights from #ESMO25 w/ @bergsa83! 5 key studies: ✅ #PSMAddition#CAPItello281#POTOMAC#Keynote905#IMvigor011 Full Discussion: - oncbrothers.com/esmo-gu-2025 - Also on the “Oncology Brothers” podcast #OncTwitter #gusm @OncUpdates @myESMO



1. #PSMAddition: PhIII, LuPSMA + ADT + ARPi vs. ADT + ARPi in mHSPC - rPFS ⬆️ with LuPSMA (HR: 0.72) - Higher xerostomia & neutropenia - How many of these pts would’ve received Chemo + ADT +ARPi today outside trial? - This will likely be another triplet available soon 3/11

OncBrothers's tweet image. 1. #PSMAddition: PhIII, LuPSMA + ADT + ARPi vs. ADT + ARPi in mHSPC

- rPFS ⬆️ with LuPSMA (HR: 0.72)
- Higher xerostomia & neutropenia
- How many of these pts would’ve received Chemo + ADT +ARPi today outside trial? 
- This will likely be another triplet available soon

3/11
OncBrothers's tweet image. 1. #PSMAddition: PhIII, LuPSMA + ADT + ARPi vs. ADT + ARPi in mHSPC

- rPFS ⬆️ with LuPSMA (HR: 0.72)
- Higher xerostomia & neutropenia
- How many of these pts would’ve received Chemo + ADT +ARPi today outside trial? 
- This will likely be another triplet available soon

3/11
OncBrothers's tweet image. 1. #PSMAddition: PhIII, LuPSMA + ADT + ARPi vs. ADT + ARPi in mHSPC

- rPFS ⬆️ with LuPSMA (HR: 0.72)
- Higher xerostomia & neutropenia
- How many of these pts would’ve received Chemo + ADT +ARPi today outside trial? 
- This will likely be another triplet available soon

3/11
OncBrothers's tweet image. 1. #PSMAddition: PhIII, LuPSMA + ADT + ARPi vs. ADT + ARPi in mHSPC

- rPFS ⬆️ with LuPSMA (HR: 0.72)
- Higher xerostomia & neutropenia
- How many of these pts would’ve received Chemo + ADT +ARPi today outside trial? 
- This will likely be another triplet available soon

3/11

🎯PSMAddition ph 3 study in 1L mHSPC ADT + ARPI +/- LutPSMA🔥 👉 rPFSby BIRC -the primary endpoint was met!! 👉 OS immature! Other new intensification triplet in mHSPC (with 70% of AntiAr hormone in doublet control arm!) RLTs is arriving in to early disease!🙌@myESMO @OncoAlert

cdanicas's tweet image. 🎯PSMAddition ph 3 study in 1L mHSPC ADT + ARPI +/- LutPSMA🔥
👉 rPFSby BIRC -the primary endpoint was met!!
👉 OS immature!
Other new intensification triplet in mHSPC (with 70% of AntiAr hormone in doublet control arm!) RLTs is arriving in to early disease!🙌@myESMO @OncoAlert…
cdanicas's tweet image. 🎯PSMAddition ph 3 study in 1L mHSPC ADT + ARPI +/- LutPSMA🔥
👉 rPFSby BIRC -the primary endpoint was met!!
👉 OS immature!
Other new intensification triplet in mHSPC (with 70% of AntiAr hormone in doublet control arm!) RLTs is arriving in to early disease!🙌@myESMO @OncoAlert…
cdanicas's tweet image. 🎯PSMAddition ph 3 study in 1L mHSPC ADT + ARPI +/- LutPSMA🔥
👉 rPFSby BIRC -the primary endpoint was met!!
👉 OS immature!
Other new intensification triplet in mHSPC (with 70% of AntiAr hormone in doublet control arm!) RLTs is arriving in to early disease!🙌@myESMO @OncoAlert…
cdanicas's tweet image. 🎯PSMAddition ph 3 study in 1L mHSPC ADT + ARPI +/- LutPSMA🔥
👉 rPFSby BIRC -the primary endpoint was met!!
👉 OS immature!
Other new intensification triplet in mHSPC (with 70% of AntiAr hormone in doublet control arm!) RLTs is arriving in to early disease!🙌@myESMO @OncoAlert…


#ESMO25 Abstract Highlights! #PSMAddition: PhIII, LuPSMA + ADT + ARPi vs. ADT + ARPi in mHSPC 🎯rPFS ⬆️w/LuPSMA (primary endpoint met) (HR 0.72) ⚠️OS immature 🚀 LuPSMA triplet likely joining mHSPC intensification options soon #MedTwitter #OncTwitter #OncTwitter #MedX

OncUpdates's tweet image. #ESMO25 Abstract Highlights! 

#PSMAddition: PhIII, LuPSMA + ADT + ARPi vs. ADT + ARPi in mHSPC

🎯rPFS ⬆️w/LuPSMA (primary endpoint met) (HR 0.72)
⚠️OS immature
🚀 LuPSMA triplet likely joining mHSPC intensification options soon

#MedTwitter #OncTwitter #OncTwitter #MedX
OncUpdates's tweet image. #ESMO25 Abstract Highlights! 

#PSMAddition: PhIII, LuPSMA + ADT + ARPi vs. ADT + ARPi in mHSPC

🎯rPFS ⬆️w/LuPSMA (primary endpoint met) (HR 0.72)
⚠️OS immature
🚀 LuPSMA triplet likely joining mHSPC intensification options soon

#MedTwitter #OncTwitter #OncTwitter #MedX
OncUpdates's tweet image. #ESMO25 Abstract Highlights! 

#PSMAddition: PhIII, LuPSMA + ADT + ARPi vs. ADT + ARPi in mHSPC

🎯rPFS ⬆️w/LuPSMA (primary endpoint met) (HR 0.72)
⚠️OS immature
🚀 LuPSMA triplet likely joining mHSPC intensification options soon

#MedTwitter #OncTwitter #OncTwitter #MedX
OncUpdates's tweet image. #ESMO25 Abstract Highlights! 

#PSMAddition: PhIII, LuPSMA + ADT + ARPi vs. ADT + ARPi in mHSPC

🎯rPFS ⬆️w/LuPSMA (primary endpoint met) (HR 0.72)
⚠️OS immature
🚀 LuPSMA triplet likely joining mHSPC intensification options soon

#MedTwitter #OncTwitter #OncTwitter #MedX

Expert #ProstateCancer panel #UromigosLive day 2 in #PSMAddition met rPFS ❓will OS be positive (immature, allowed crossover) ❓QoL vs AE ❓long-term tox - renal & 2ary malignancies ❓do all pts need all 6 doses ❓better pt selection - SUVmean or total PSMA tumor volume

DrKarineTawagi's tweet image. Expert #ProstateCancer panel  #UromigosLive day 2 in #PSMAddition met rPFS

❓will OS be positive (immature, allowed crossover)
❓QoL vs AE
❓long-term tox - renal & 2ary malignancies 
❓do all pts need all 6 doses 
❓better pt selection - SUVmean or total PSMA tumor volume
DrKarineTawagi's tweet image. Expert #ProstateCancer panel  #UromigosLive day 2 in #PSMAddition met rPFS

❓will OS be positive (immature, allowed crossover)
❓QoL vs AE
❓long-term tox - renal & 2ary malignancies 
❓do all pts need all 6 doses 
❓better pt selection - SUVmean or total PSMA tumor volume
DrKarineTawagi's tweet image. Expert #ProstateCancer panel  #UromigosLive day 2 in #PSMAddition met rPFS

❓will OS be positive (immature, allowed crossover)
❓QoL vs AE
❓long-term tox - renal & 2ary malignancies 
❓do all pts need all 6 doses 
❓better pt selection - SUVmean or total PSMA tumor volume

As presented at #ESMO25, second interim analysis results from the #PSMAddition trial showed that adding 177Lu-PSMA-617 to standard ADT plus an ARPI significantly improved rPFS in metastatic hormone-sensitive prostate cancer. Learn more: hmpgloballearningnetwork.com/site/onc/news/…

OncLearnNetwork's tweet image. As presented at #ESMO25, second interim analysis results from the #PSMAddition trial showed that adding 177Lu-PSMA-617 to standard ADT plus an ARPI significantly improved rPFS in metastatic hormone-sensitive prostate cancer. Learn more: hmpgloballearningnetwork.com/site/onc/news/…

At #ESMO25, Scott Tagawa, MD, discusses results from the #PSMAddition trial evaluating the addition of 177Lu-PSMA-617 to ADT and ARPI therapy for patients with metastatic hormone-sensitive prostate cancer. Learn more: hmpgloballearningnetwork.com/site/onc/video… #medtwitter #onctwitter

OncLearnNetwork's tweet image. At #ESMO25, Scott Tagawa, MD, discusses results from the #PSMAddition trial evaluating the addition of 177Lu-PSMA-617 to ADT and ARPI therapy for patients with metastatic hormone-sensitive prostate cancer. Learn more: hmpgloballearningnetwork.com/site/onc/video…

#medtwitter #onctwitter

Day 3 #ESMO25 Highlights: Prostate Ca 1. #PSMAddition: LuPSMA in mHSPC 2. #ENZARD: ADT+XRT+/-Enza 3. #EMBARK: Enza biochem recurrent Prostate Ca 4. #CAPItello281: Abi+/-Capi in PTEN Mesothelioma: 5. #DREAM3R: Durva+Chemo 1L #OncTwitter @OncUpdates @OncoAlert 1/11

OncBrothers's tweet image. Day 3 #ESMO25 Highlights: 

Prostate Ca  
1. #PSMAddition: LuPSMA in mHSPC 

2. #ENZARD: ADT+XRT+/-Enza 

3. #EMBARK: Enza biochem recurrent Prostate Ca

4. #CAPItello281: Abi+/-Capi in PTEN 

Mesothelioma:
5. #DREAM3R: Durva+Chemo 1L 

#OncTwitter @OncUpdates @OncoAlert 
1/11

GU Malignancy Highlights from #ESMO25 w/ @bergsa83! 5 key studies: ✅ #PSMAddition#CAPItello281#POTOMAC#Keynote905#IMvigor011 Full Discussion: - oncbrothers.com/esmo-gu-2025 - Also on the “Oncology Brothers” podcast #OncTwitter #gusm @OncUpdates @myESMO


Interim #PSMAddition analysis shows lutetium PSMA-617 improves rPFS in #mHSPC. @DrScottTagawa @WeillCornell joins Oliver Sartor, MD @EJHospital to discuss on UroToday > bit.ly/4hLFCiJ @PCFnews @PCF_Science #PCFRetreat25

urotoday's tweet image. Interim #PSMAddition analysis shows lutetium PSMA-617 improves rPFS in #mHSPC. @DrScottTagawa @WeillCornell joins Oliver Sartor, MD @EJHospital to discuss on UroToday > bit.ly/4hLFCiJ @PCFnews @PCF_Science #PCFRetreat25

#PSMAddition: PhIII, LuPSMA + ADT + ARPi vs. ADT + ARPi in mHSPC 🎯rPFS ⬆️w/LuPSMA (primary endpoint met) (HR 0.72) ⚠️OS immature 🚀 LuPSMA triplet likely joining mHSPC intensification options soon #MedTwitter #OncTwitter #OncTwitter #MedX

OncUpdates's tweet image. #PSMAddition: PhIII, LuPSMA + ADT + ARPi vs. ADT + ARPi in mHSPC

🎯rPFS ⬆️w/LuPSMA (primary endpoint met) (HR 0.72)
⚠️OS immature
🚀 LuPSMA triplet likely joining mHSPC intensification options soon

#MedTwitter #OncTwitter #OncTwitter #MedX
OncUpdates's tweet image. #PSMAddition: PhIII, LuPSMA + ADT + ARPi vs. ADT + ARPi in mHSPC

🎯rPFS ⬆️w/LuPSMA (primary endpoint met) (HR 0.72)
⚠️OS immature
🚀 LuPSMA triplet likely joining mHSPC intensification options soon

#MedTwitter #OncTwitter #OncTwitter #MedX
OncUpdates's tweet image. #PSMAddition: PhIII, LuPSMA + ADT + ARPi vs. ADT + ARPi in mHSPC

🎯rPFS ⬆️w/LuPSMA (primary endpoint met) (HR 0.72)
⚠️OS immature
🚀 LuPSMA triplet likely joining mHSPC intensification options soon

#MedTwitter #OncTwitter #OncTwitter #MedX

Phase III trial of [177Lu]Lu-PSMA-617 combined with ADT + ARPI in patients with PSMA-positive metastatic hormone-sensitive #ProstateCancer #PSMAddition. Presented by @DrScottTagawa @WeillCornell. #ESMO25 written coverage by @RKSayyid @UAUrology > bit.ly/4nZfS4N @myESMO

urotoday's tweet image. Phase III trial of [177Lu]Lu-PSMA-617 combined with ADT + ARPI in patients with PSMA-positive metastatic hormone-sensitive #ProstateCancer #PSMAddition. Presented by @DrScottTagawa @WeillCornell. #ESMO25 written coverage by @RKSayyid @UAUrology > bit.ly/4nZfS4N @myESMO
urotoday's tweet image. Phase III trial of [177Lu]Lu-PSMA-617 combined with ADT + ARPI in patients with PSMA-positive metastatic hormone-sensitive #ProstateCancer #PSMAddition. Presented by @DrScottTagawa @WeillCornell. #ESMO25 written coverage by @RKSayyid @UAUrology > bit.ly/4nZfS4N @myESMO
urotoday's tweet image. Phase III trial of [177Lu]Lu-PSMA-617 combined with ADT + ARPI in patients with PSMA-positive metastatic hormone-sensitive #ProstateCancer #PSMAddition. Presented by @DrScottTagawa @WeillCornell. #ESMO25 written coverage by @RKSayyid @UAUrology > bit.ly/4nZfS4N @myESMO
urotoday's tweet image. Phase III trial of [177Lu]Lu-PSMA-617 combined with ADT + ARPI in patients with PSMA-positive metastatic hormone-sensitive #ProstateCancer #PSMAddition. Presented by @DrScottTagawa @WeillCornell. #ESMO25 written coverage by @RKSayyid @UAUrology > bit.ly/4nZfS4N @myESMO

Quelle serait l'étude phase 2 ou 3 en ce moment sur laquelle vous mettriez de bons espoirs sur les kc prostate métastatiques sensibles à la castration? je pensais à #psmaddition? #afu #urologie #doctoctoc RT appreciés..


#PSMAddition: a phase 3 trial to compare treatment with 177Lu-PSMA-617 + Standard of Care vs SOC alone in patients with #mHSPC. Presentation by @DrScottTagawa @WeillCornell. #ESMO21 written coverage by @WallisCJD @UofT on UroToday > bit.ly/3Epp0cn @myESMO

urotoday's tweet image. #PSMAddition: a phase 3 trial to compare treatment with 177Lu-PSMA-617 + Standard of Care vs SOC alone in patients with #mHSPC. Presentation by @DrScottTagawa @WeillCornell. #ESMO21 written coverage by @WallisCJD @UofT on UroToday > bit.ly/3Epp0cn @myESMO

Want to learn about trials in progress at #ASCO23? Check out abstract no. TPS5116 on Sat, June 3 from 8 to 11 AM CDT for the latest Novartis presentation from the #PSMAddition Phase 3 study on RLT plus SOC vs SOC alone in patients with metastatic hormone-sensitive prostate cancer


Completely agree @DrMHofman. We have already achieved major improvements with systemic therapy and it is incumbent on us to prove that PSMA-TRT is more effective and as safe. Fortunately trials available such as #UpFrontPSMA and #PSMAddition

This post is unavailable.

Expert #ProstateCancer panel #UromigosLive day 2 in #PSMAddition met rPFS ❓will OS be positive (immature, allowed crossover) ❓QoL vs AE ❓long-term tox - renal & 2ary malignancies ❓do all pts need all 6 doses ❓better pt selection - SUVmean or total PSMA tumor volume

DrKarineTawagi's tweet image. Expert #ProstateCancer panel  #UromigosLive day 2 in #PSMAddition met rPFS

❓will OS be positive (immature, allowed crossover)
❓QoL vs AE
❓long-term tox - renal & 2ary malignancies 
❓do all pts need all 6 doses 
❓better pt selection - SUVmean or total PSMA tumor volume
DrKarineTawagi's tweet image. Expert #ProstateCancer panel  #UromigosLive day 2 in #PSMAddition met rPFS

❓will OS be positive (immature, allowed crossover)
❓QoL vs AE
❓long-term tox - renal & 2ary malignancies 
❓do all pts need all 6 doses 
❓better pt selection - SUVmean or total PSMA tumor volume
DrKarineTawagi's tweet image. Expert #ProstateCancer panel  #UromigosLive day 2 in #PSMAddition met rPFS

❓will OS be positive (immature, allowed crossover)
❓QoL vs AE
❓long-term tox - renal & 2ary malignancies 
❓do all pts need all 6 doses 
❓better pt selection - SUVmean or total PSMA tumor volume

Interim #PSMAddition analysis shows lutetium PSMA-617 improves rPFS in #mHSPC. @DrScottTagawa @WeillCornell joins Oliver Sartor, MD @EJHospital to discuss on UroToday > bit.ly/4hLFCiJ @PCFnews @PCF_Science #PCFRetreat25

urotoday's tweet image. Interim #PSMAddition analysis shows lutetium PSMA-617 improves rPFS in #mHSPC. @DrScottTagawa @WeillCornell joins Oliver Sartor, MD @EJHospital to discuss on UroToday > bit.ly/4hLFCiJ @PCFnews @PCF_Science #PCFRetreat25

#PSMAddition: PhIII, LuPSMA + ADT + ARPi vs. ADT + ARPi in mHSPC 🎯rPFS ⬆️w/LuPSMA (primary endpoint met) (HR 0.72) ⚠️OS immature 🚀 LuPSMA triplet likely joining mHSPC intensification options soon #MedTwitter #OncTwitter #OncTwitter #MedX

OncUpdates's tweet image. #PSMAddition: PhIII, LuPSMA + ADT + ARPi vs. ADT + ARPi in mHSPC

🎯rPFS ⬆️w/LuPSMA (primary endpoint met) (HR 0.72)
⚠️OS immature
🚀 LuPSMA triplet likely joining mHSPC intensification options soon

#MedTwitter #OncTwitter #OncTwitter #MedX
OncUpdates's tweet image. #PSMAddition: PhIII, LuPSMA + ADT + ARPi vs. ADT + ARPi in mHSPC

🎯rPFS ⬆️w/LuPSMA (primary endpoint met) (HR 0.72)
⚠️OS immature
🚀 LuPSMA triplet likely joining mHSPC intensification options soon

#MedTwitter #OncTwitter #OncTwitter #MedX
OncUpdates's tweet image. #PSMAddition: PhIII, LuPSMA + ADT + ARPi vs. ADT + ARPi in mHSPC

🎯rPFS ⬆️w/LuPSMA (primary endpoint met) (HR 0.72)
⚠️OS immature
🚀 LuPSMA triplet likely joining mHSPC intensification options soon

#MedTwitter #OncTwitter #OncTwitter #MedX

At #ESMO25, Scott Tagawa, MD, discusses results from the #PSMAddition trial evaluating the addition of 177Lu-PSMA-617 to ADT and ARPI therapy for patients with metastatic hormone-sensitive prostate cancer. Learn more: hmpgloballearningnetwork.com/site/onc/video… #medtwitter #onctwitter

OncLearnNetwork's tweet image. At #ESMO25, Scott Tagawa, MD, discusses results from the #PSMAddition trial evaluating the addition of 177Lu-PSMA-617 to ADT and ARPI therapy for patients with metastatic hormone-sensitive prostate cancer. Learn more: hmpgloballearningnetwork.com/site/onc/video…

#medtwitter #onctwitter

5 GU studies that we focused on during our conference highlight discussion with @bergsa83 from #ESMO25: ✅ #PSMAddition by @DrScottTagawa#CAPItello281#POTOMAC#Keynote905/EV303 ✅ #IMvigor011 by @tompowles1 #gusm #OncTwitter #MedTwitter @OncUpdates

OncBrothers's tweet image. 5 GU studies that we focused on during our conference highlight discussion with @bergsa83 from #ESMO25: 

✅ #PSMAddition by @DrScottTagawa 
✅ #CAPItello281
✅ #POTOMAC
✅ #Keynote905/EV303
✅ #IMvigor011 by @tompowles1 

#gusm #OncTwitter #MedTwitter @OncUpdates

GU Malignancy Highlights from #ESMO25 w/ @bergsa83! 5 key studies: ✅ #PSMAddition#CAPItello281#POTOMAC#Keynote905#IMvigor011 Full Discussion: - oncbrothers.com/esmo-gu-2025 - Also on the “Oncology Brothers” podcast #OncTwitter #gusm @OncUpdates @myESMO



GU Malignancy Highlights from #ESMO25 w/ @bergsa83! 5 key studies: ✅ #PSMAddition#CAPItello281#POTOMAC#Keynote905#IMvigor011 Full Discussion: - oncbrothers.com/esmo-gu-2025 - Also on the “Oncology Brothers” podcast #OncTwitter #gusm @OncUpdates @myESMO


#Prostatakrebs: Radioligandentherapie erfolgreich bei hormonsensitiven #Tumoren geprüft. #PSMAddition-Studie vom @myESMO-Kongress deutet darauf hin, dass nicht nur Patienten mit metastasiertem kastrationsresistenten #Prostatakarzinom profitieren. tinyurl.com/2ypw4kt8


A reflection of key prostate studies at @myESMO #ESMO25, starting with #PSMAddition. First positive study of a radioligand in mHSPC, with significant PFS improvement (HR 0.72), favourable safety profile. Complete response rates notably higher, 57% and 42% 1/4

Kenrickng1's tweet image. A reflection of key prostate studies at @myESMO #ESMO25, starting with #PSMAddition. First positive study of a radioligand in mHSPC, with significant PFS improvement (HR 0.72), favourable safety profile. Complete response rates notably higher, 57% and 42% 1/4

Phase III trial of [177Lu]Lu-PSMA-617 combined with ADT + ARPI in patients with PSMA-positive #mHSPC #PSMAddition. Presentation by @AzadOncology @PeterMacCC. #ESMO25 written coverage by @RKSayyid @UAUrology > bit.ly/3WRb2u8 @myESMO

urotoday's tweet image. Phase III trial of [177Lu]Lu-PSMA-617 combined with ADT + ARPI in patients with PSMA-positive #mHSPC #PSMAddition. Presentation by @AzadOncology @PeterMacCC. #ESMO25 written coverage by @RKSayyid @UAUrology > bit.ly/3WRb2u8 @myESMO
urotoday's tweet image. Phase III trial of [177Lu]Lu-PSMA-617 combined with ADT + ARPI in patients with PSMA-positive #mHSPC #PSMAddition. Presentation by @AzadOncology @PeterMacCC. #ESMO25 written coverage by @RKSayyid @UAUrology > bit.ly/3WRb2u8 @myESMO
urotoday's tweet image. Phase III trial of [177Lu]Lu-PSMA-617 combined with ADT + ARPI in patients with PSMA-positive #mHSPC #PSMAddition. Presentation by @AzadOncology @PeterMacCC. #ESMO25 written coverage by @RKSayyid @UAUrology > bit.ly/3WRb2u8 @myESMO
urotoday's tweet image. Phase III trial of [177Lu]Lu-PSMA-617 combined with ADT + ARPI in patients with PSMA-positive #mHSPC #PSMAddition. Presentation by @AzadOncology @PeterMacCC. #ESMO25 written coverage by @RKSayyid @UAUrology > bit.ly/3WRb2u8 @myESMO

#ESMO25 Abstract Highlights! #PSMAddition: PhIII, LuPSMA + ADT + ARPi vs. ADT + ARPi in mHSPC 🎯rPFS ⬆️w/LuPSMA (primary endpoint met) (HR 0.72) ⚠️OS immature 🚀 LuPSMA triplet likely joining mHSPC intensification options soon #MedTwitter #OncTwitter #OncTwitter #MedX

OncUpdates's tweet image. #ESMO25 Abstract Highlights! 

#PSMAddition: PhIII, LuPSMA + ADT + ARPi vs. ADT + ARPi in mHSPC

🎯rPFS ⬆️w/LuPSMA (primary endpoint met) (HR 0.72)
⚠️OS immature
🚀 LuPSMA triplet likely joining mHSPC intensification options soon

#MedTwitter #OncTwitter #OncTwitter #MedX
OncUpdates's tweet image. #ESMO25 Abstract Highlights! 

#PSMAddition: PhIII, LuPSMA + ADT + ARPi vs. ADT + ARPi in mHSPC

🎯rPFS ⬆️w/LuPSMA (primary endpoint met) (HR 0.72)
⚠️OS immature
🚀 LuPSMA triplet likely joining mHSPC intensification options soon

#MedTwitter #OncTwitter #OncTwitter #MedX
OncUpdates's tweet image. #ESMO25 Abstract Highlights! 

#PSMAddition: PhIII, LuPSMA + ADT + ARPi vs. ADT + ARPi in mHSPC

🎯rPFS ⬆️w/LuPSMA (primary endpoint met) (HR 0.72)
⚠️OS immature
🚀 LuPSMA triplet likely joining mHSPC intensification options soon

#MedTwitter #OncTwitter #OncTwitter #MedX
OncUpdates's tweet image. #ESMO25 Abstract Highlights! 

#PSMAddition: PhIII, LuPSMA + ADT + ARPi vs. ADT + ARPi in mHSPC

🎯rPFS ⬆️w/LuPSMA (primary endpoint met) (HR 0.72)
⚠️OS immature
🚀 LuPSMA triplet likely joining mHSPC intensification options soon

#MedTwitter #OncTwitter #OncTwitter #MedX

@AzadOncology delivered one of the most thorough and balanced discussions I’ve ever heard. Excellent summary ⬇️. Congratulations to @DrScottTagawa on an excellent presentation and to the #PSMAddition investigators for addressing the role of Lu-PSMA-617 in mHSPC. #ESMO25

AmandaNizamMD's tweet image. @AzadOncology delivered one of the most thorough and balanced discussions I’ve ever heard. Excellent summary ⬇️. 

Congratulations to @DrScottTagawa on an excellent presentation and to the #PSMAddition investigators for addressing the role of Lu-PSMA-617 in mHSPC. #ESMO25…

Congrats to @DrScottTagawa on his presentation of PSMA-Addition, and to @AzadOncology on a very thoughtful discussion. Compelling data data but agree with Azad’s take that questions remain. Excellent points around the possibility of a “sink effect” & risks of secondary…

montypal's tweet image. Congrats to @DrScottTagawa on his presentation of PSMA-Addition, and to @AzadOncology on a very thoughtful discussion. Compelling data data but agree with Azad’s take that questions remain. Excellent points around the possibility of a “sink effect” & risks of secondary…
montypal's tweet image. Congrats to @DrScottTagawa on his presentation of PSMA-Addition, and to @AzadOncology on a very thoughtful discussion. Compelling data data but agree with Azad’s take that questions remain. Excellent points around the possibility of a “sink effect” & risks of secondary…


1. #PSMAddition: PhIII, LuPSMA + ADT + ARPi vs. ADT + ARPi in mHSPC - rPFS ⬆️ with LuPSMA (HR: 0.72) - Higher xerostomia & neutropenia - How many of these pts would’ve received Chemo + ADT +ARPi today outside trial? - This will likely be another triplet available soon 3/11

OncBrothers's tweet image. 1. #PSMAddition: PhIII, LuPSMA + ADT + ARPi vs. ADT + ARPi in mHSPC

- rPFS ⬆️ with LuPSMA (HR: 0.72)
- Higher xerostomia & neutropenia
- How many of these pts would’ve received Chemo + ADT +ARPi today outside trial? 
- This will likely be another triplet available soon

3/11
OncBrothers's tweet image. 1. #PSMAddition: PhIII, LuPSMA + ADT + ARPi vs. ADT + ARPi in mHSPC

- rPFS ⬆️ with LuPSMA (HR: 0.72)
- Higher xerostomia & neutropenia
- How many of these pts would’ve received Chemo + ADT +ARPi today outside trial? 
- This will likely be another triplet available soon

3/11
OncBrothers's tweet image. 1. #PSMAddition: PhIII, LuPSMA + ADT + ARPi vs. ADT + ARPi in mHSPC

- rPFS ⬆️ with LuPSMA (HR: 0.72)
- Higher xerostomia & neutropenia
- How many of these pts would’ve received Chemo + ADT +ARPi today outside trial? 
- This will likely be another triplet available soon

3/11
OncBrothers's tweet image. 1. #PSMAddition: PhIII, LuPSMA + ADT + ARPi vs. ADT + ARPi in mHSPC

- rPFS ⬆️ with LuPSMA (HR: 0.72)
- Higher xerostomia & neutropenia
- How many of these pts would’ve received Chemo + ADT +ARPi today outside trial? 
- This will likely be another triplet available soon

3/11

🎯PSMAddition ph 3 study in 1L mHSPC ADT + ARPI +/- LutPSMA🔥 👉 rPFSby BIRC -the primary endpoint was met!! 👉 OS immature! Other new intensification triplet in mHSPC (with 70% of AntiAr hormone in doublet control arm!) RLTs is arriving in to early disease!🙌@myESMO @OncoAlert

cdanicas's tweet image. 🎯PSMAddition ph 3 study in 1L mHSPC ADT + ARPI +/- LutPSMA🔥
👉 rPFSby BIRC -the primary endpoint was met!!
👉 OS immature!
Other new intensification triplet in mHSPC (with 70% of AntiAr hormone in doublet control arm!) RLTs is arriving in to early disease!🙌@myESMO @OncoAlert…
cdanicas's tweet image. 🎯PSMAddition ph 3 study in 1L mHSPC ADT + ARPI +/- LutPSMA🔥
👉 rPFSby BIRC -the primary endpoint was met!!
👉 OS immature!
Other new intensification triplet in mHSPC (with 70% of AntiAr hormone in doublet control arm!) RLTs is arriving in to early disease!🙌@myESMO @OncoAlert…
cdanicas's tweet image. 🎯PSMAddition ph 3 study in 1L mHSPC ADT + ARPI +/- LutPSMA🔥
👉 rPFSby BIRC -the primary endpoint was met!!
👉 OS immature!
Other new intensification triplet in mHSPC (with 70% of AntiAr hormone in doublet control arm!) RLTs is arriving in to early disease!🙌@myESMO @OncoAlert…
cdanicas's tweet image. 🎯PSMAddition ph 3 study in 1L mHSPC ADT + ARPI +/- LutPSMA🔥
👉 rPFSby BIRC -the primary endpoint was met!!
👉 OS immature!
Other new intensification triplet in mHSPC (with 70% of AntiAr hormone in doublet control arm!) RLTs is arriving in to early disease!🙌@myESMO @OncoAlert…


Day 3 #ESMO25 Highlights: Prostate Ca 1. #PSMAddition: LuPSMA in mHSPC 2. #ENZARD: ADT+XRT+/-Enza 3. #EMBARK: Enza biochem recurrent Prostate Ca 4. #CAPItello281: Abi+/-Capi in PTEN Mesothelioma: 5. #DREAM3R: Durva+Chemo 1L #OncTwitter @OncUpdates @OncoAlert 1/11

OncBrothers's tweet image. Day 3 #ESMO25 Highlights: 

Prostate Ca  
1. #PSMAddition: LuPSMA in mHSPC 

2. #ENZARD: ADT+XRT+/-Enza 

3. #EMBARK: Enza biochem recurrent Prostate Ca

4. #CAPItello281: Abi+/-Capi in PTEN 

Mesothelioma:
5. #DREAM3R: Durva+Chemo 1L 

#OncTwitter @OncUpdates @OncoAlert 
1/11

Phase III trial of [177Lu]Lu-PSMA-617 combined with ADT + ARPI in patients with PSMA-positive metastatic hormone-sensitive #ProstateCancer #PSMAddition. Presented by @DrScottTagawa @WeillCornell. #ESMO25 written coverage by @RKSayyid @UAUrology > bit.ly/4nZfS4N @myESMO

urotoday's tweet image. Phase III trial of [177Lu]Lu-PSMA-617 combined with ADT + ARPI in patients with PSMA-positive metastatic hormone-sensitive #ProstateCancer #PSMAddition. Presented by @DrScottTagawa @WeillCornell. #ESMO25 written coverage by @RKSayyid @UAUrology > bit.ly/4nZfS4N @myESMO
urotoday's tweet image. Phase III trial of [177Lu]Lu-PSMA-617 combined with ADT + ARPI in patients with PSMA-positive metastatic hormone-sensitive #ProstateCancer #PSMAddition. Presented by @DrScottTagawa @WeillCornell. #ESMO25 written coverage by @RKSayyid @UAUrology > bit.ly/4nZfS4N @myESMO
urotoday's tweet image. Phase III trial of [177Lu]Lu-PSMA-617 combined with ADT + ARPI in patients with PSMA-positive metastatic hormone-sensitive #ProstateCancer #PSMAddition. Presented by @DrScottTagawa @WeillCornell. #ESMO25 written coverage by @RKSayyid @UAUrology > bit.ly/4nZfS4N @myESMO
urotoday's tweet image. Phase III trial of [177Lu]Lu-PSMA-617 combined with ADT + ARPI in patients with PSMA-positive metastatic hormone-sensitive #ProstateCancer #PSMAddition. Presented by @DrScottTagawa @WeillCornell. #ESMO25 written coverage by @RKSayyid @UAUrology > bit.ly/4nZfS4N @myESMO

🎯Patient individualisation is a Must! For Patient selection and follow up! The aim is that the Patient live longer BUT also BETTER 🥇 #qualityoflife #PSMAddition #ESMO25 #prostatacancer @DrScottTagawa

UroTeragLATAM's tweet image. 🎯Patient individualisation is a Must! For Patient selection and follow up! The aim is that the Patient live longer BUT also BETTER 🥇 #qualityoflife #PSMAddition #ESMO25 #prostatacancer @DrScottTagawa
UroTeragLATAM's tweet image. 🎯Patient individualisation is a Must! For Patient selection and follow up! The aim is that the Patient live longer BUT also BETTER 🥇 #qualityoflife #PSMAddition #ESMO25 #prostatacancer @DrScottTagawa
UroTeragLATAM's tweet image. 🎯Patient individualisation is a Must! For Patient selection and follow up! The aim is that the Patient live longer BUT also BETTER 🥇 #qualityoflife #PSMAddition #ESMO25 #prostatacancer @DrScottTagawa

Breakthrough in #PSMAddition: 177Lu-PSMA-617+ ADT+ARPi significant improve rPFS in patients with PSMA-pos mHSPC. Data reveals an HR of 0.27. Adverse event profile remained within expected for #Lu177PSMA treatment with no unexpected increases when combined with ADT+ARPI #ESMO25

UroTeragLATAM's tweet image. Breakthrough in #PSMAddition: 177Lu-PSMA-617+ ADT+ARPi significant improve rPFS in patients with PSMA-pos mHSPC. Data reveals an HR of 0.27. Adverse event profile remained within expected for #Lu177PSMA treatment with no unexpected increases when combined with ADT+ARPI #ESMO25
UroTeragLATAM's tweet image. Breakthrough in #PSMAddition: 177Lu-PSMA-617+ ADT+ARPi significant improve rPFS in patients with PSMA-pos mHSPC. Data reveals an HR of 0.27. Adverse event profile remained within expected for #Lu177PSMA treatment with no unexpected increases when combined with ADT+ARPI #ESMO25
UroTeragLATAM's tweet image. Breakthrough in #PSMAddition: 177Lu-PSMA-617+ ADT+ARPi significant improve rPFS in patients with PSMA-pos mHSPC. Data reveals an HR of 0.27. Adverse event profile remained within expected for #Lu177PSMA treatment with no unexpected increases when combined with ADT+ARPI #ESMO25

#PSMAddition (LBA6, #ESMO25 )The phase 3 PSMAddition trial brings radioligand therapy into the mHSPC setting. In 1,144 PSMA+ patients, adding [^177Lu]Lu-PSMA-617 to ADT + ARPI significantly improved rPFS (HR 0.72, p = 0.002) ✅ 85% completed all 6 Lu-PSMA cycles.

docjavip's tweet image. #PSMAddition (LBA6, #ESMO25 )The phase 3 PSMAddition trial brings radioligand therapy into the mHSPC setting.

In 1,144 PSMA+ patients, adding [^177Lu]Lu-PSMA-617 to ADT + ARPI significantly improved rPFS (HR 0.72, p = 0.002)

✅ 85% completed all 6 Lu-PSMA cycles.
docjavip's tweet image. #PSMAddition (LBA6, #ESMO25 )The phase 3 PSMAddition trial brings radioligand therapy into the mHSPC setting.

In 1,144 PSMA+ patients, adding [^177Lu]Lu-PSMA-617 to ADT + ARPI significantly improved rPFS (HR 0.72, p = 0.002)

✅ 85% completed all 6 Lu-PSMA cycles.

As presented at #ESMO25, second interim analysis results from the #PSMAddition trial showed that adding 177Lu-PSMA-617 to standard ADT plus an ARPI significantly improved rPFS in metastatic hormone-sensitive prostate cancer. Learn more: hmpgloballearningnetwork.com/site/onc/news/…

OncLearnNetwork's tweet image. As presented at #ESMO25, second interim analysis results from the #PSMAddition trial showed that adding 177Lu-PSMA-617 to standard ADT plus an ARPI significantly improved rPFS in metastatic hormone-sensitive prostate cancer. Learn more: hmpgloballearningnetwork.com/site/onc/news/…

#PSMAddition: A phase 3 trial to compare treatment with 177Lu-PSMA-617 + standard of care and standard of care alone in patients with #mHSPC. Presentation by @DrScottTagawa @WeillCornell. #ASCO23 written coverage by @zklaassen_md @GACancerCenter > bit.ly/3CdnCda @ASCO

urotoday's tweet image. #PSMAddition: A phase 3 trial to compare treatment with 177Lu-PSMA-617 + standard of care and standard of care alone in patients with #mHSPC. Presentation by @DrScottTagawa @WeillCornell. #ASCO23 written coverage by @zklaassen_md @GACancerCenter > bit.ly/3CdnCda @ASCO
urotoday's tweet image. #PSMAddition: A phase 3 trial to compare treatment with 177Lu-PSMA-617 + standard of care and standard of care alone in patients with #mHSPC. Presentation by @DrScottTagawa @WeillCornell. #ASCO23 written coverage by @zklaassen_md @GACancerCenter > bit.ly/3CdnCda @ASCO

Want to learn about trials in progress at #ASCO23? Check out abstract no. TPS5116 on Sat, June 3 from 8 to 11 AM CDT for the latest Novartis presentation from the #PSMAddition Phase 3 study on RLT plus SOC vs SOC alone in patients with metastatic hormone-sensitive prostate cancer


No results for "#psmaddition"

🎯Patient individualisation is a Must! For Patient selection and follow up! The aim is that the Patient live longer BUT also BETTER 🥇 #qualityoflife #PSMAddition #ESMO25 #prostatacancer @DrScottTagawa

UroTeragLATAM's tweet image. 🎯Patient individualisation is a Must! For Patient selection and follow up! The aim is that the Patient live longer BUT also BETTER 🥇 #qualityoflife #PSMAddition #ESMO25 #prostatacancer @DrScottTagawa
UroTeragLATAM's tweet image. 🎯Patient individualisation is a Must! For Patient selection and follow up! The aim is that the Patient live longer BUT also BETTER 🥇 #qualityoflife #PSMAddition #ESMO25 #prostatacancer @DrScottTagawa
UroTeragLATAM's tweet image. 🎯Patient individualisation is a Must! For Patient selection and follow up! The aim is that the Patient live longer BUT also BETTER 🥇 #qualityoflife #PSMAddition #ESMO25 #prostatacancer @DrScottTagawa

A reflection of key prostate studies at @myESMO #ESMO25, starting with #PSMAddition. First positive study of a radioligand in mHSPC, with significant PFS improvement (HR 0.72), favourable safety profile. Complete response rates notably higher, 57% and 42% 1/4

Kenrickng1's tweet image. A reflection of key prostate studies at @myESMO #ESMO25, starting with #PSMAddition. First positive study of a radioligand in mHSPC, with significant PFS improvement (HR 0.72), favourable safety profile. Complete response rates notably higher, 57% and 42% 1/4

#PSMAddition (LBA6, #ESMO25 )The phase 3 PSMAddition trial brings radioligand therapy into the mHSPC setting. In 1,144 PSMA+ patients, adding [^177Lu]Lu-PSMA-617 to ADT + ARPI significantly improved rPFS (HR 0.72, p = 0.002) ✅ 85% completed all 6 Lu-PSMA cycles.

docjavip's tweet image. #PSMAddition (LBA6, #ESMO25 )The phase 3 PSMAddition trial brings radioligand therapy into the mHSPC setting.

In 1,144 PSMA+ patients, adding [^177Lu]Lu-PSMA-617 to ADT + ARPI significantly improved rPFS (HR 0.72, p = 0.002)

✅ 85% completed all 6 Lu-PSMA cycles.
docjavip's tweet image. #PSMAddition (LBA6, #ESMO25 )The phase 3 PSMAddition trial brings radioligand therapy into the mHSPC setting.

In 1,144 PSMA+ patients, adding [^177Lu]Lu-PSMA-617 to ADT + ARPI significantly improved rPFS (HR 0.72, p = 0.002)

✅ 85% completed all 6 Lu-PSMA cycles.

Breakthrough in #PSMAddition: 177Lu-PSMA-617+ ADT+ARPi significant improve rPFS in patients with PSMA-pos mHSPC. Data reveals an HR of 0.27. Adverse event profile remained within expected for #Lu177PSMA treatment with no unexpected increases when combined with ADT+ARPI #ESMO25

UroTeragLATAM's tweet image. Breakthrough in #PSMAddition: 177Lu-PSMA-617+ ADT+ARPi significant improve rPFS in patients with PSMA-pos mHSPC. Data reveals an HR of 0.27. Adverse event profile remained within expected for #Lu177PSMA treatment with no unexpected increases when combined with ADT+ARPI #ESMO25
UroTeragLATAM's tweet image. Breakthrough in #PSMAddition: 177Lu-PSMA-617+ ADT+ARPi significant improve rPFS in patients with PSMA-pos mHSPC. Data reveals an HR of 0.27. Adverse event profile remained within expected for #Lu177PSMA treatment with no unexpected increases when combined with ADT+ARPI #ESMO25
UroTeragLATAM's tweet image. Breakthrough in #PSMAddition: 177Lu-PSMA-617+ ADT+ARPi significant improve rPFS in patients with PSMA-pos mHSPC. Data reveals an HR of 0.27. Adverse event profile remained within expected for #Lu177PSMA treatment with no unexpected increases when combined with ADT+ARPI #ESMO25

5 GU studies that we focused on during our conference highlight discussion with @bergsa83 from #ESMO25: ✅ #PSMAddition by @DrScottTagawa#CAPItello281#POTOMAC#Keynote905/EV303 ✅ #IMvigor011 by @tompowles1 #gusm #OncTwitter #MedTwitter @OncUpdates

OncBrothers's tweet image. 5 GU studies that we focused on during our conference highlight discussion with @bergsa83 from #ESMO25: 

✅ #PSMAddition by @DrScottTagawa 
✅ #CAPItello281
✅ #POTOMAC
✅ #Keynote905/EV303
✅ #IMvigor011 by @tompowles1 

#gusm #OncTwitter #MedTwitter @OncUpdates

GU Malignancy Highlights from #ESMO25 w/ @bergsa83! 5 key studies: ✅ #PSMAddition#CAPItello281#POTOMAC#Keynote905#IMvigor011 Full Discussion: - oncbrothers.com/esmo-gu-2025 - Also on the “Oncology Brothers” podcast #OncTwitter #gusm @OncUpdates @myESMO



1. #PSMAddition: PhIII, LuPSMA + ADT + ARPi vs. ADT + ARPi in mHSPC - rPFS ⬆️ with LuPSMA (HR: 0.72) - Higher xerostomia & neutropenia - How many of these pts would’ve received Chemo + ADT +ARPi today outside trial? - This will likely be another triplet available soon 3/11

OncBrothers's tweet image. 1. #PSMAddition: PhIII, LuPSMA + ADT + ARPi vs. ADT + ARPi in mHSPC

- rPFS ⬆️ with LuPSMA (HR: 0.72)
- Higher xerostomia & neutropenia
- How many of these pts would’ve received Chemo + ADT +ARPi today outside trial? 
- This will likely be another triplet available soon

3/11
OncBrothers's tweet image. 1. #PSMAddition: PhIII, LuPSMA + ADT + ARPi vs. ADT + ARPi in mHSPC

- rPFS ⬆️ with LuPSMA (HR: 0.72)
- Higher xerostomia & neutropenia
- How many of these pts would’ve received Chemo + ADT +ARPi today outside trial? 
- This will likely be another triplet available soon

3/11
OncBrothers's tweet image. 1. #PSMAddition: PhIII, LuPSMA + ADT + ARPi vs. ADT + ARPi in mHSPC

- rPFS ⬆️ with LuPSMA (HR: 0.72)
- Higher xerostomia & neutropenia
- How many of these pts would’ve received Chemo + ADT +ARPi today outside trial? 
- This will likely be another triplet available soon

3/11
OncBrothers's tweet image. 1. #PSMAddition: PhIII, LuPSMA + ADT + ARPi vs. ADT + ARPi in mHSPC

- rPFS ⬆️ with LuPSMA (HR: 0.72)
- Higher xerostomia & neutropenia
- How many of these pts would’ve received Chemo + ADT +ARPi today outside trial? 
- This will likely be another triplet available soon

3/11

🎯PSMAddition ph 3 study in 1L mHSPC ADT + ARPI +/- LutPSMA🔥 👉 rPFSby BIRC -the primary endpoint was met!! 👉 OS immature! Other new intensification triplet in mHSPC (with 70% of AntiAr hormone in doublet control arm!) RLTs is arriving in to early disease!🙌@myESMO @OncoAlert

cdanicas's tweet image. 🎯PSMAddition ph 3 study in 1L mHSPC ADT + ARPI +/- LutPSMA🔥
👉 rPFSby BIRC -the primary endpoint was met!!
👉 OS immature!
Other new intensification triplet in mHSPC (with 70% of AntiAr hormone in doublet control arm!) RLTs is arriving in to early disease!🙌@myESMO @OncoAlert…
cdanicas's tweet image. 🎯PSMAddition ph 3 study in 1L mHSPC ADT + ARPI +/- LutPSMA🔥
👉 rPFSby BIRC -the primary endpoint was met!!
👉 OS immature!
Other new intensification triplet in mHSPC (with 70% of AntiAr hormone in doublet control arm!) RLTs is arriving in to early disease!🙌@myESMO @OncoAlert…
cdanicas's tweet image. 🎯PSMAddition ph 3 study in 1L mHSPC ADT + ARPI +/- LutPSMA🔥
👉 rPFSby BIRC -the primary endpoint was met!!
👉 OS immature!
Other new intensification triplet in mHSPC (with 70% of AntiAr hormone in doublet control arm!) RLTs is arriving in to early disease!🙌@myESMO @OncoAlert…
cdanicas's tweet image. 🎯PSMAddition ph 3 study in 1L mHSPC ADT + ARPI +/- LutPSMA🔥
👉 rPFSby BIRC -the primary endpoint was met!!
👉 OS immature!
Other new intensification triplet in mHSPC (with 70% of AntiAr hormone in doublet control arm!) RLTs is arriving in to early disease!🙌@myESMO @OncoAlert…


#ESMO25 Abstract Highlights! #PSMAddition: PhIII, LuPSMA + ADT + ARPi vs. ADT + ARPi in mHSPC 🎯rPFS ⬆️w/LuPSMA (primary endpoint met) (HR 0.72) ⚠️OS immature 🚀 LuPSMA triplet likely joining mHSPC intensification options soon #MedTwitter #OncTwitter #OncTwitter #MedX

OncUpdates's tweet image. #ESMO25 Abstract Highlights! 

#PSMAddition: PhIII, LuPSMA + ADT + ARPi vs. ADT + ARPi in mHSPC

🎯rPFS ⬆️w/LuPSMA (primary endpoint met) (HR 0.72)
⚠️OS immature
🚀 LuPSMA triplet likely joining mHSPC intensification options soon

#MedTwitter #OncTwitter #OncTwitter #MedX
OncUpdates's tweet image. #ESMO25 Abstract Highlights! 

#PSMAddition: PhIII, LuPSMA + ADT + ARPi vs. ADT + ARPi in mHSPC

🎯rPFS ⬆️w/LuPSMA (primary endpoint met) (HR 0.72)
⚠️OS immature
🚀 LuPSMA triplet likely joining mHSPC intensification options soon

#MedTwitter #OncTwitter #OncTwitter #MedX
OncUpdates's tweet image. #ESMO25 Abstract Highlights! 

#PSMAddition: PhIII, LuPSMA + ADT + ARPi vs. ADT + ARPi in mHSPC

🎯rPFS ⬆️w/LuPSMA (primary endpoint met) (HR 0.72)
⚠️OS immature
🚀 LuPSMA triplet likely joining mHSPC intensification options soon

#MedTwitter #OncTwitter #OncTwitter #MedX
OncUpdates's tweet image. #ESMO25 Abstract Highlights! 

#PSMAddition: PhIII, LuPSMA + ADT + ARPi vs. ADT + ARPi in mHSPC

🎯rPFS ⬆️w/LuPSMA (primary endpoint met) (HR 0.72)
⚠️OS immature
🚀 LuPSMA triplet likely joining mHSPC intensification options soon

#MedTwitter #OncTwitter #OncTwitter #MedX

Day 3 #ESMO25 Highlights: Prostate Ca 1. #PSMAddition: LuPSMA in mHSPC 2. #ENZARD: ADT+XRT+/-Enza 3. #EMBARK: Enza biochem recurrent Prostate Ca 4. #CAPItello281: Abi+/-Capi in PTEN Mesothelioma: 5. #DREAM3R: Durva+Chemo 1L #OncTwitter @OncUpdates @OncoAlert 1/11

OncBrothers's tweet image. Day 3 #ESMO25 Highlights: 

Prostate Ca  
1. #PSMAddition: LuPSMA in mHSPC 

2. #ENZARD: ADT+XRT+/-Enza 

3. #EMBARK: Enza biochem recurrent Prostate Ca

4. #CAPItello281: Abi+/-Capi in PTEN 

Mesothelioma:
5. #DREAM3R: Durva+Chemo 1L 

#OncTwitter @OncUpdates @OncoAlert 
1/11

As presented at #ESMO25, second interim analysis results from the #PSMAddition trial showed that adding 177Lu-PSMA-617 to standard ADT plus an ARPI significantly improved rPFS in metastatic hormone-sensitive prostate cancer. Learn more: hmpgloballearningnetwork.com/site/onc/news/…

OncLearnNetwork's tweet image. As presented at #ESMO25, second interim analysis results from the #PSMAddition trial showed that adding 177Lu-PSMA-617 to standard ADT plus an ARPI significantly improved rPFS in metastatic hormone-sensitive prostate cancer. Learn more: hmpgloballearningnetwork.com/site/onc/news/…

@AzadOncology delivered one of the most thorough and balanced discussions I’ve ever heard. Excellent summary ⬇️. Congratulations to @DrScottTagawa on an excellent presentation and to the #PSMAddition investigators for addressing the role of Lu-PSMA-617 in mHSPC. #ESMO25

AmandaNizamMD's tweet image. @AzadOncology delivered one of the most thorough and balanced discussions I’ve ever heard. Excellent summary ⬇️. 

Congratulations to @DrScottTagawa on an excellent presentation and to the #PSMAddition investigators for addressing the role of Lu-PSMA-617 in mHSPC. #ESMO25…

Congrats to @DrScottTagawa on his presentation of PSMA-Addition, and to @AzadOncology on a very thoughtful discussion. Compelling data data but agree with Azad’s take that questions remain. Excellent points around the possibility of a “sink effect” & risks of secondary…

montypal's tweet image. Congrats to @DrScottTagawa on his presentation of PSMA-Addition, and to @AzadOncology on a very thoughtful discussion. Compelling data data but agree with Azad’s take that questions remain. Excellent points around the possibility of a “sink effect” & risks of secondary…
montypal's tweet image. Congrats to @DrScottTagawa on his presentation of PSMA-Addition, and to @AzadOncology on a very thoughtful discussion. Compelling data data but agree with Azad’s take that questions remain. Excellent points around the possibility of a “sink effect” & risks of secondary…


At #ESMO25, Scott Tagawa, MD, discusses results from the #PSMAddition trial evaluating the addition of 177Lu-PSMA-617 to ADT and ARPI therapy for patients with metastatic hormone-sensitive prostate cancer. Learn more: hmpgloballearningnetwork.com/site/onc/video… #medtwitter #onctwitter

OncLearnNetwork's tweet image. At #ESMO25, Scott Tagawa, MD, discusses results from the #PSMAddition trial evaluating the addition of 177Lu-PSMA-617 to ADT and ARPI therapy for patients with metastatic hormone-sensitive prostate cancer. Learn more: hmpgloballearningnetwork.com/site/onc/video…

#medtwitter #onctwitter

#PSMAddition: a phase 3 trial to compare treatment with 177Lu-PSMA-617 + Standard of Care vs SOC alone in patients with #mHSPC. Presentation by @DrScottTagawa @WeillCornell. #ESMO21 written coverage by @WallisCJD @UofT on UroToday > bit.ly/3Epp0cn @myESMO

urotoday's tweet image. #PSMAddition: a phase 3 trial to compare treatment with 177Lu-PSMA-617 + Standard of Care vs SOC alone in patients with #mHSPC. Presentation by @DrScottTagawa @WeillCornell. #ESMO21 written coverage by @WallisCJD @UofT on UroToday > bit.ly/3Epp0cn @myESMO

#PSMAddition: PhIII, LuPSMA + ADT + ARPi vs. ADT + ARPi in mHSPC 🎯rPFS ⬆️w/LuPSMA (primary endpoint met) (HR 0.72) ⚠️OS immature 🚀 LuPSMA triplet likely joining mHSPC intensification options soon #MedTwitter #OncTwitter #OncTwitter #MedX

OncUpdates's tweet image. #PSMAddition: PhIII, LuPSMA + ADT + ARPi vs. ADT + ARPi in mHSPC

🎯rPFS ⬆️w/LuPSMA (primary endpoint met) (HR 0.72)
⚠️OS immature
🚀 LuPSMA triplet likely joining mHSPC intensification options soon

#MedTwitter #OncTwitter #OncTwitter #MedX
OncUpdates's tweet image. #PSMAddition: PhIII, LuPSMA + ADT + ARPi vs. ADT + ARPi in mHSPC

🎯rPFS ⬆️w/LuPSMA (primary endpoint met) (HR 0.72)
⚠️OS immature
🚀 LuPSMA triplet likely joining mHSPC intensification options soon

#MedTwitter #OncTwitter #OncTwitter #MedX
OncUpdates's tweet image. #PSMAddition: PhIII, LuPSMA + ADT + ARPi vs. ADT + ARPi in mHSPC

🎯rPFS ⬆️w/LuPSMA (primary endpoint met) (HR 0.72)
⚠️OS immature
🚀 LuPSMA triplet likely joining mHSPC intensification options soon

#MedTwitter #OncTwitter #OncTwitter #MedX

Interim #PSMAddition analysis shows lutetium PSMA-617 improves rPFS in #mHSPC. @DrScottTagawa @WeillCornell joins Oliver Sartor, MD @EJHospital to discuss on UroToday > bit.ly/4hLFCiJ @PCFnews @PCF_Science #PCFRetreat25

urotoday's tweet image. Interim #PSMAddition analysis shows lutetium PSMA-617 improves rPFS in #mHSPC. @DrScottTagawa @WeillCornell joins Oliver Sartor, MD @EJHospital to discuss on UroToday > bit.ly/4hLFCiJ @PCFnews @PCF_Science #PCFRetreat25

Phase III trial of [177Lu]Lu-PSMA-617 combined with ADT + ARPI in patients with PSMA-positive metastatic hormone-sensitive #ProstateCancer #PSMAddition. Presented by @DrScottTagawa @WeillCornell. #ESMO25 written coverage by @RKSayyid @UAUrology > bit.ly/4nZfS4N @myESMO

urotoday's tweet image. Phase III trial of [177Lu]Lu-PSMA-617 combined with ADT + ARPI in patients with PSMA-positive metastatic hormone-sensitive #ProstateCancer #PSMAddition. Presented by @DrScottTagawa @WeillCornell. #ESMO25 written coverage by @RKSayyid @UAUrology > bit.ly/4nZfS4N @myESMO
urotoday's tweet image. Phase III trial of [177Lu]Lu-PSMA-617 combined with ADT + ARPI in patients with PSMA-positive metastatic hormone-sensitive #ProstateCancer #PSMAddition. Presented by @DrScottTagawa @WeillCornell. #ESMO25 written coverage by @RKSayyid @UAUrology > bit.ly/4nZfS4N @myESMO
urotoday's tweet image. Phase III trial of [177Lu]Lu-PSMA-617 combined with ADT + ARPI in patients with PSMA-positive metastatic hormone-sensitive #ProstateCancer #PSMAddition. Presented by @DrScottTagawa @WeillCornell. #ESMO25 written coverage by @RKSayyid @UAUrology > bit.ly/4nZfS4N @myESMO
urotoday's tweet image. Phase III trial of [177Lu]Lu-PSMA-617 combined with ADT + ARPI in patients with PSMA-positive metastatic hormone-sensitive #ProstateCancer #PSMAddition. Presented by @DrScottTagawa @WeillCornell. #ESMO25 written coverage by @RKSayyid @UAUrology > bit.ly/4nZfS4N @myESMO

Expert #ProstateCancer panel #UromigosLive day 2 in #PSMAddition met rPFS ❓will OS be positive (immature, allowed crossover) ❓QoL vs AE ❓long-term tox - renal & 2ary malignancies ❓do all pts need all 6 doses ❓better pt selection - SUVmean or total PSMA tumor volume

DrKarineTawagi's tweet image. Expert #ProstateCancer panel  #UromigosLive day 2 in #PSMAddition met rPFS

❓will OS be positive (immature, allowed crossover)
❓QoL vs AE
❓long-term tox - renal & 2ary malignancies 
❓do all pts need all 6 doses 
❓better pt selection - SUVmean or total PSMA tumor volume
DrKarineTawagi's tweet image. Expert #ProstateCancer panel  #UromigosLive day 2 in #PSMAddition met rPFS

❓will OS be positive (immature, allowed crossover)
❓QoL vs AE
❓long-term tox - renal & 2ary malignancies 
❓do all pts need all 6 doses 
❓better pt selection - SUVmean or total PSMA tumor volume
DrKarineTawagi's tweet image. Expert #ProstateCancer panel  #UromigosLive day 2 in #PSMAddition met rPFS

❓will OS be positive (immature, allowed crossover)
❓QoL vs AE
❓long-term tox - renal & 2ary malignancies 
❓do all pts need all 6 doses 
❓better pt selection - SUVmean or total PSMA tumor volume

#PSMAddition: A phase 3 trial to compare treatment with 177Lu-PSMA-617 + standard of care and standard of care alone in patients with #mHSPC. Presentation by @DrScottTagawa @WeillCornell. #ASCO23 written coverage by @zklaassen_md @GACancerCenter > bit.ly/3CdnCda @ASCO

urotoday's tweet image. #PSMAddition: A phase 3 trial to compare treatment with 177Lu-PSMA-617 + standard of care and standard of care alone in patients with #mHSPC. Presentation by @DrScottTagawa @WeillCornell. #ASCO23 written coverage by @zklaassen_md @GACancerCenter > bit.ly/3CdnCda @ASCO
urotoday's tweet image. #PSMAddition: A phase 3 trial to compare treatment with 177Lu-PSMA-617 + standard of care and standard of care alone in patients with #mHSPC. Presentation by @DrScottTagawa @WeillCornell. #ASCO23 written coverage by @zklaassen_md @GACancerCenter > bit.ly/3CdnCda @ASCO

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