#slayerstructure search results
3. The 3D crystals are made of stacks of 2D lattices of SlpA #xraycrystallography #SlayerStructure #BugSlayer 5/n
2. the complex is maintained by an intricate “paperclip” motif by the interacting domains. #SlayerStructure #xraycrystallography #BugSlayer 4/n
7. The #Cdiff #BugSlayer is very tightly packed, with pores of only about 11A, so only small ions can diffuse through #SlayerStructure 9/n
5. The crystal packing of SlpA mimics the assembly of the S-layer in the cells, so interactions in the crystal are a model for how the #BugSlayer assembles. #SlayerStructure 7/n
8. Removing the most exposed SLPL domain (D2), doesn’t change the overall SlpA structure and a functional S-layer is assembled. However, #Cdiff then becomes susceptible to lysozyme, even though the pores are still very narrow (16A). #SlayerStructure #BugSlayers 10/n
Many new questions to answer: how do things go in/out of the #Cdiff cells? How can we disrupt this armour? How does the #SlayerStructure link to function and infection? Lots to keep us busy, but for now, a huge thank you to the whole @BugS_layers team! 11/11
Our work revealing the structure and organisation of #BugSlayer in #Cdiff is finally out in @NatComms! Huge team effort from joint 1st authors @PaolaLanzoni, @barwinskasendra, @JSamWilson, @OishikBanerji! #SlayerStructure nature.com/articles/s4146… 1/n
Together with @Joekaryotic, @filipacostavaz, @GillDouce1, @FairweatherNeil, Shauna O’Beirne, Arnaud Basle, Kamel el Omari and Armin Wenger, coordinated by @PerBullough, @RobFagan and @pssalgado! #SlayerStructure 2/n
#Cdiff #Slayerstructure #BugSlayer Fascinating story of an arduous journey with happy ending - many congrats Paula and team @paolalanzoni @barwinskasendra
7. The #Cdiff #BugSlayer is very tightly packed, with pores of only about 11A, so only small ions can diffuse through #SlayerStructure 9/n dlvr.it/SKw0zN #cdi #cdiff
7. The #Cdiff #BugSlayer is very tightly packed, with pores of only about 11A, so only small ions can diffuse through #SlayerStructure 9/n dlvr.it/SKw0zN #cdi #cdiff
#Cdiff #Slayerstructure #BugSlayer Fascinating story of an arduous journey with happy ending - many congrats Paula and team @paolalanzoni @barwinskasendra
Many new questions to answer: how do things go in/out of the #Cdiff cells? How can we disrupt this armour? How does the #SlayerStructure link to function and infection? Lots to keep us busy, but for now, a huge thank you to the whole @BugS_layers team! 11/11
8. Removing the most exposed SLPL domain (D2), doesn’t change the overall SlpA structure and a functional S-layer is assembled. However, #Cdiff then becomes susceptible to lysozyme, even though the pores are still very narrow (16A). #SlayerStructure #BugSlayers 10/n
7. The #Cdiff #BugSlayer is very tightly packed, with pores of only about 11A, so only small ions can diffuse through #SlayerStructure 9/n
5. The crystal packing of SlpA mimics the assembly of the S-layer in the cells, so interactions in the crystal are a model for how the #BugSlayer assembles. #SlayerStructure 7/n
3. The 3D crystals are made of stacks of 2D lattices of SlpA #xraycrystallography #SlayerStructure #BugSlayer 5/n
2. the complex is maintained by an intricate “paperclip” motif by the interacting domains. #SlayerStructure #xraycrystallography #BugSlayer 4/n
Together with @Joekaryotic, @filipacostavaz, @GillDouce1, @FairweatherNeil, Shauna O’Beirne, Arnaud Basle, Kamel el Omari and Armin Wenger, coordinated by @PerBullough, @RobFagan and @pssalgado! #SlayerStructure 2/n
Our work revealing the structure and organisation of #BugSlayer in #Cdiff is finally out in @NatComms! Huge team effort from joint 1st authors @PaolaLanzoni, @barwinskasendra, @JSamWilson, @OishikBanerji! #SlayerStructure nature.com/articles/s4146… 1/n
3. The 3D crystals are made of stacks of 2D lattices of SlpA #xraycrystallography #SlayerStructure #BugSlayer 5/n
2. the complex is maintained by an intricate “paperclip” motif by the interacting domains. #SlayerStructure #xraycrystallography #BugSlayer 4/n
7. The #Cdiff #BugSlayer is very tightly packed, with pores of only about 11A, so only small ions can diffuse through #SlayerStructure 9/n
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