#nrf2 search results
In my blog I discuss how #Nrf2 activators with EC50 similar to GC50 are likely activating #Nrf2 through response to cytotoxicity, with poor tolerability in clinical translation. New approach #GlucoRegulate avoided this with effective clinical translation. pjthornalley.com/index.php/blog/
In my blog I discuss why delivering health benefit from #Nrf2 activators has stalled: unclear activation mechanism and toxicity. New approaches with #GlucoRegulate (trans-#resveratrol and #hesperetin combination) is a new, clinically effective approach. pjthornalley.com/index.php/blog/
Many believe plant antioxidants are healthy due to stimulating the NRF2 pathway, boosting antioxidant production. However, these compounds aren't antioxidants; they're pro-oxidants, eliciting a hormetic response. This is similar to how toxins activate NRF2. #antioxidants #NRF2
In my blog I explain how #resveratrol (tRES) and #hesperetin (HESP) combination activate master health protector #Nrf2 through activation of PKA. HESP decreases EC50 of tRES, bringing it into the physiological concentration range for clinical response. pjthornalley.com/index.php/blog/
酸化ストレスを巧みに感知する生体の仕組みが明らかに！ ストレスセンサー「KEAP1」が刺激に応じて、転写因子NRF2を活性化および抑制化の両方向性に調節する分子機構を解明しました。 詳細は megabank.tohoku.ac.jp/news/63370 から！ #KEAP1 #NRF2 #酸化ストレス
In my blog (pjthornalley.com/index.php/blog/), I discuss pharmacological responses achievable clinically with #resveratrol: #Nrf2 activation, #PDE-1 and aromatic hydrocarbon receptor inhibition. Nrf2 activation is potentiated by Hesperetin, as in #GlucoRegulate. mdpi.com/2076-3921/14/8…
La Regeneración celular optimizada, nos ralentiza los achaques del envejecimiento y la oxidación celular, lo que se traduce en una mejor función de todo nuestro organismo. Info DM #nrf2 #joeMcCord #GNMX #PathwaysBioscience #ACTIVZ
On #MASLD we propose #Nrf2 activator #GlucoRegulate for therapy. It: increases G6PD to counter glycolytic overload, ChREBP activation and lipogenesis; increases Glo1 to counter UPR activation and inflammation; and decreases SREBP1 to counter lipogenesis. portlandpress.com/clinsci/articl…
portlandpress.com
Molecular mechanisms of metabolic dysfunction-associated steatotic liver disease (MASLD): functio...
Metabolic dysfunction–associated steatotic liver disease (MASLD) is a major non-communicable disease with global prevalence of 38% and no early-stage treatment. It has risk factors of insulin...
Con mi papá platicando de nuestra empresa ACTIVZ, la empresa que cambia vidas en salud y economía, no hay otro producto para la salud con un plan de compensación como este. Enamorada del producto ya estaba, pero el plan de negocio es extraordinario. Te cuento todo, info DM #nrf2
私たちの細胞には「酸化ストレス」から身を守るための防衛システムが備わっています。 このシステム、普段は「ロック」がかかっているのですが、ポリフェノールが、このロックを解除する「鍵」のように働き、システムを起動させるきっかけに？ #Nrf2 #ポリフェノール note.com/ptgolfer/n/nc3…
Multifaceted Roles of #NRF2 in #Cancer: Friend or Foe? mdpi.com/2076-3921/13/1… @_atanas_ @_INPST @ScienceCommuni2 @DHPSP @DominicDAgosti2 @DrPalmquist @CancerResrch @cancernewstoday @OncologyTimes @cancerresearchr
Metformin decelerates aging clock in male monkeys cell.com/cell/abstract/… @CellCellPress #Neuro_aging, #Metaformin, #Nrf2, #Longevity
Hoy nuestra compañera Ángela ha expuesto su presentación sobre el papel de los compuestos inductores de #NRF2 como terapia para el #Alzheimer en la Training School de @benbedphar 👏
🚨👩🏼🔬🧪👨🏻🔬‼️ Today the leader of @FatlivL Dr. Angela M. Valverde has presented our new data about the potetial role of NRF2 in preserving hepatic progenitor cell fate at the 4th BenBedPhar Sci Meeting held in Zagreb 🇭🇷 Hope you enjoy it! #BenBedPhar #NRF2 #OvalCells #LiverDiseases
Testimonios de mejoría extraordinaria de parálisis facial con GNM-X de ACTIVZ autorizados para su difusión. Prevención y mejoría de Más de 250 enfermedades crónico neuro degenerativas. Info DM 🙌 #nrf2 #DrJoeMiltonMcCord #epigenética #ciencia #salud #ACTIVZ
We start September with good news! We have just had a new manuscript accepted: repurposing an activator of #NRF2 in #TDP-43 dependent frontotemporal #dementia. This work is part of @ignaciosilva96 doctoral thesis in collaboration with @DeFemia @BBM_UCM @UAM_Madrid @IIBmCSICUAM
A perfect summer read! Our latest review on #aging, #NRF2 and #TAU. Do not miss it!!! @IIBmCSICUAM @SaludISCIII @IdiPAZScience @ucc_complutense @UAM_Madrid @antioxidants_OA
We optimised #GlucoRegulate supplement for activation of master cytoprotector #Nrf2, combining hesperetin with trans-#Resveratrol, not cis-. trans- is about 20-fold more effective than cis; latter likely not achieving effective concentrations clinically. mdpi.com/2076-3921/14/8…
📚 Read our #published Review "#Melatonin-Mediated #Nrf2 Activation as a Potential Therapeutic Strategy in Mutation-Driven #Neurodegenerative Diseases" by Lucía Íñigo-Catalina, et al. 🔺 Access the full text at: mdpi.com/2076-3921/14/1… 🔺 SI Open: mdpi.com/journal/antiox…
On #MASLD we propose #Nrf2 activator #GlucoRegulate for therapy. It: increases G6PD to counter glycolytic overload, ChREBP activation and lipogenesis; increases Glo1 to counter UPR activation and inflammation; and decreases SREBP1 to counter lipogenesis. portlandpress.com/clinsci/articl…
portlandpress.com
Molecular mechanisms of metabolic dysfunction-associated steatotic liver disease (MASLD): functio...
Metabolic dysfunction–associated steatotic liver disease (MASLD) is a major non-communicable disease with global prevalence of 38% and no early-stage treatment. It has risk factors of insulin...
Metabolic analysis - supported by pre-clinical studies and a clinical study - suggests activation of #Nrf2 would be more effective. #MASLD #glycolyticoverload See portlandpress.com/clinsci/articl…
portlandpress.com
Molecular mechanisms of metabolic dysfunction-associated steatotic liver disease (MASLD): functio...
Metabolic dysfunction–associated steatotic liver disease (MASLD) is a major non-communicable disease with global prevalence of 38% and no early-stage treatment. It has risk factors of insulin...
Nrf2 also known as nuclear factor erythroid 2-related factor 2 is a transcription factor. enkilife.com/p/Phospho-Nrf2… #Antibodies #Nrf2 #antioxidant #oxidative
Extract from buried Phoebe zhennan wood (BPE) relieves physical fatigue by activating Nrf-2/HO-1 and AMPK/PGC-1α pathways. Improves endurance, reduces oxidative stress, and protects muscles. 🔗 doi.org/10.53388/TMR20… #PhysicalFatigue #AntiFatigue #Nrf2 #AMPK
Latest Review in @Landmark_IMR Ionizing Radiation in Clinical Diagnostics and Radiotherapy: The Dual Role of NRF2 in Cell Protection and Carcinogenesis ➡️imrpress.com/journal/FBL/30… 👨🎓Alessandra Verdina, Gabriella D’Orazi #NRF2 #Keap1 #ROS #oxidativestress #DNArepair #cancer #imaging
Latest Review in @Landmark_IMR Ionizing Radiation in Clinical Diagnostics and Radiotherapy: The Dual Role of NRF2 in Cell Protection and Carcinogenesis ➡️imrpress.com/journal/FBL/30… 👨🎓Alessandra Verdina, Gabriella D’Orazi #NRF2 #Keap1 #ROS #oxidativestress #DNArepair #cancer #imaging
酸化ストレスを巧みに感知する生体の仕組みが明らかに！ ストレスセンサー「KEAP1」が刺激に応じて、転写因子NRF2を活性化および抑制化の両方向性に調節する分子機構を解明しました。 詳細は megabank.tohoku.ac.jp/news/63370 から！ #KEAP1 #NRF2 #酸化ストレス
🧬 Your Cells Have a Defense Mode Here’s How to Activate It! Broccoli, kale, and green tea aren’t just “health foods” 🌿 They flip the switch on your body’s NRF2 pathway your built-in defense system against stress, toxins, and aging. ⚡ #CellularHealth #NRF2 #LongevityNutrition
In my blog I discuss how #Nrf2 activators with EC50 similar to GC50 are likely activating #Nrf2 through response to cytotoxicity, with poor tolerability in clinical translation. New approach #GlucoRegulate avoided this with effective clinical translation. pjthornalley.com/index.php/blog/
📚 Read our #published Review "Non-#Electrophilic Activation of #NRF2 in #Neurological #Disorders: Therapeutic Promise of Non-Pharmacological Strategies" by Chunyan Li, et al. 🔺 Access the full text at: mdpi.com/2076-3921/14/9… 🔺 Special Issue Open: mdpi.com/journal/antiox…
Multifaceted Roles of #NRF2 in #Cancer: Friend or Foe? mdpi.com/2076-3921/13/1… @_atanas_ @_INPST @ScienceCommuni2 @DHPSP @DominicDAgosti2 @DrPalmquist @CancerResrch @cancernewstoday @OncologyTimes @cancerresearchr
🚀 From Bench to Paper | Targeting #NRF2 reverses lung cancer immunosuppression— published in #Nature #Lung tumors hijack NRF2 in bone marrow progenitors → driving immunosuppressive mo-macs. · NRF2 boosts myelopoiesis but dampens immunity · Blocking NRF2 restores T/NK function +…
Are you interested in #NRF2 and #ALS? Here you can find the last news about!!!! @Biomol_MDPI @DeFemia @Isalabe13 @MadridEla @IIBmCSICUAM @CIB_CSIC
This week some members of our lab have attended the BenBedPhar Training School 2023 at the wonderful Smolenice Castle in Slovakia @benbedphar #nrf2
DM to learn more. #nrf2 #natural #Menopause #cellularhealth #agingbody #healthylifestyle #askme #wellnesscoach
A perfect summer read! Our latest review on #aging, #NRF2 and #TAU. Do not miss it!!! @IIBmCSICUAM @SaludISCIII @IdiPAZScience @ucc_complutense @UAM_Madrid @antioxidants_OA
In my blog I discuss why delivering health benefit from #Nrf2 activators has stalled: unclear activation mechanism and toxicity. New approaches with #GlucoRegulate (trans-#resveratrol and #hesperetin combination) is a new, clinically effective approach. pjthornalley.com/index.php/blog/
Con mi papá platicando de nuestra empresa ACTIVZ, la empresa que cambia vidas en salud y economía, no hay otro producto para la salud con un plan de compensación como este. Enamorada del producto ya estaba, pero el plan de negocio es extraordinario. Te cuento todo, info DM #nrf2
Testimonios de mejoría extraordinaria de parálisis facial con GNM-X de ACTIVZ autorizados para su difusión. Prevención y mejoría de Más de 250 enfermedades crónico neuro degenerativas. Info DM 🙌 #nrf2 #DrJoeMiltonMcCord #epigenética #ciencia #salud #ACTIVZ
Read the article on #NRF2 signaling thresholds in lung cancer initiation and progression, by @LabDeNicola and stop by to visit first author Janine DeBlasi at her #AACR23 poster now (Section 1 Board 12)— bit.ly/3A2rah9
#Nrf2Energy #Nrf2 #NRF1 #Nutrigenomics #Phytonutrients #Protandim #LittleYellowPill #Nrf2Activated #Nrf1Activation #Validated #Science #LookYounger #FeelYounger #PerformBetter #SleepBetter #Nrf2opportunity #LFVN #LifeVantage #WorldChangers #Petandim #TrueScience #AXIO #PhysIQ
In my blog I explain how #resveratrol (tRES) and #hesperetin (HESP) combination activate master health protector #Nrf2 through activation of PKA. HESP decreases EC50 of tRES, bringing it into the physiological concentration range for clinical response. pjthornalley.com/index.php/blog/
KEAP1-NRF2系が生体内において、酸化ストレスを感知して生体の恒常性を維持する巧妙な仕組みを明らかにして論文として発表しました！ 詳細は megabank.tohoku.ac.jp/news/59336 をご覧ください。 #NRF2 #KEAP1
📜State-of-the-Art Review Ferroptosis: regulation by competition between NRF2 and BACH1 and propagation of the death signal 🔗buff.ly/3ZK8UUn ✒️By Kazuhiko Igarashi & colleagues @kazuigarashi @hironishiZw @tohoku_univ #ferroptosis #celldeath #NRF2 #transcriptionfactor
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