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BasuLab1's profile picture. Cancer surgeon-scientist @PennMedicine. Our lab advances therapy for #headandneckcancer #HPV #hnscm. Opinions my own. Patient appointments 2156626972

Devraj Basu, MD, PhD, FACS

@BasuLab1

Cancer surgeon-scientist @PennMedicine. Our lab advances therapy for #headandneckcancer #HPV #hnscm. Opinions my own. Patient appointments 2156626972

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Devraj Basu, MD, PhD, FACS
 @BasuLab1
Mar 30

@JNCI_Now We defined the gene expression profiles distinguishing HPV+ OPSCCs that are prone to recur after TORS-based therapy. These the tumor-intrinsic and immune-related traits were tightly interrelated and generalizeable to nonsurgical cases as well. academic.oup.com/jnci/advance-a…

BasuLab1's tweet image. @JNCI_Now We defined the gene expression profiles distinguishing HPV+ OPSCCs that are prone to recur after TORS-based therapy. These the tumor-intrinsic and immune-related traits were tightly interrelated and generalizeable to nonsurgical cases as well. academic.oup.com/jnci/advance-a…
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Arthur Schopenhauer
@SchopenhauerNow
Nov 8
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David Sher
 @DavidSherMD
Oct 24

The field is understandably desperate to improve outcomes in this high-risk population of HPV-negative HNSCC. However, we also have to be cautious in interpreting phase II studies. This sub-100 patient trial led to a truly immense amount of additional work (and money) that…

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Devraj Basu, MD, PhD, FACS reposted
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David Sher
 @DavidSherMD
Oct 23

The optimal management of oligometastatic HNSCC is a debated and important question. How can we improve *overall survival* in this more favorable population? EA3211 is a phase III randomized trial studying this exact issue. Enrollment is even more streamlined with the most…

eaonc's profile picture. Biomarker-driven medical research involving adults who have or are at risk of developing cancer
ECOG-ACRIN Cancer Research Group
 @eaonc
Oct 22

#ClinicalTrial EA3211, led by @DavidSherMD of @utswcancer, aims to improve results for patients with #HeadAndNeckCancer that has spread to a limited number of places. Learn more: bit.ly/ea3211-study

eaonc's tweet image. #ClinicalTrial EA3211, led by @DavidSherMD of @utswcancer, aims to improve results for patients with #HeadAndNeckCancer that has spread to a limited number of places. Learn more: bit.ly/ea3211-study
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🔥 Matt Dancho (Business Science) 🔥
@mdancho84
Oct 13

K-means is one of the most powerful algorithms for data scientists. But it's confusing for beginners. Let's fix that:

mdancho84's tweet image. K-means is one of the most powerful algorithms for data scientists. But it's confusing for beginners. Let's fix that:
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Devraj Basu, MD, PhD, FACS reposted
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David Sher
 @DavidSherMD
Sep 30

I think we need to reserve judgement and final analysis until seeing all of the papers from these trials…. … but are these results really so different? - In the US trial, more IMRT patients (40% vs. 27% = 13% difference) received g-tubes. - In the UK trial, more IMRT patients…

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Devraj Basu, MD, PhD, FACS
 @BasuLab1
Sep 25

A hopeful NCI director choice for cancer patients and those committed to advancing cancer care. Godspeed to Dr. Letai in navigating the challenges of his new role. science.org/content/articl…

BasuLab1's tweet card. Harvard physician-scientist Anthony Letai is poised to head world’s largest cancer research agency
Researchers are relieved at Trump’s likely pick for National Cancer Institute
Source: science.org
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Devraj Basu, MD, PhD, FACS
 @BasuLab1
Sep 17

Interesting work on how anti-tumor immune suppression and anti-PD1 resistance arises via PNI and strategies to reverse it nature.com/articles/s4158…

BasuLab1's tweet card. Nature - Perineural invasion and cancer-induced nerve injury of tumour-associated nerves are associated with poor response to anti-PD-1 therapy, which can be reversed by combining anti-PD-1 therapy...
Cancer-induced nerve injury promotes resistance to anti-PD-1 therapy
Source: nature.com
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David Sher
 @DavidSherMD
Sep 7

It was such a pleasure to read the results of this juicy and terrific randomized trial of postop RT dose de-escalation for HPV+ OPSCC from @DanielMaMD and colleagues at @MayoRadOnc. The field has been waiting for the formal results, and this paper does not disappoint.…

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David Sher
 @DavidSherMD
Sep 1

This paper is a nice addition to the literature on the successful use of carboplatin-paclitaxel as a radiation sensitizer. The favorable results clearly motivate larger prospective trials on the use of carbo-pac as a radiation sensitizer in HNSCC. The most commonly delivered…

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JAMA Otolaryngology – Head & Neck Surgery
 @JAMAOto
Sep 1

In patients with SCCHN receiving radiation with C/P vs cisplatin, there were no differences in locoregional recurrence-free survival, progression-free survival, distant metastasis-free survival, and overall survival. ja.ma/47t0I24 @DRNabilSaba @NikkiSchmittMD

JAMAOto's tweet image. In patients with SCCHN receiving radiation with C/P vs cisplatin, there were no differences in locoregional recurrence-free survival, progression-free survival, distant metastasis-free survival, and overall survival. ja.ma/47t0I24 @DRNabilSaba @NikkiSchmittMD
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Adela
 @adelapoite
Sep 11

Xevinapant or Placebo Plus Platinum-Based Chemoradiotherapy in Unresected Locally Advanced Squamous Cell Carcinoma of the Head and Neck (TrilynX): A Randomized, Phase III Study | Journal of Clinical Oncology ascopubs.org/doi/10.1200/JC…

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Devraj Basu, MD, PhD, FACS
 @BasuLab1
Aug 14

Wow - some truly visionary philanthropy here. cancerletter.com/conversation-w…

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Neil D. Gross, MD, FACS
 @DrNeilGross
Aug 8

Long-Term Follow-Up of E3311, an ECOG-ACRIN Cancer Research Group Phase II Trial of Transoral Surgery and Risk-Based Adjuvant Treatment in Human Papillomavirus–Initiated Oropharynx Cancer | Journal of Clinical Oncology ascopubs.org/doi/full/10.12…

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Aaron Ring
@aaronmring
Jul 23

T cells do the heavy lifting when it comes to the anti-tumor action of checkpoint immunotherapy. But do antibodies play a role too? That’s the question @yile_dai looked to answer in his thesis work, out today in @Nature! 🧵below nature.com/articles/s4158…

aaronmring's tweet image. T cells do the heavy lifting when it comes to the anti-tumor action of checkpoint immunotherapy. But do antibodies play a role too? That’s the question @yile_dai looked to answer in his thesis work, out today in @Nature! 🧵below nature.com/articles/s4158…
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JNCI
 @JNCI_Now
Jun 21

A @PennCancer team has defined a network of tumor-intrinsic and immune-related molecular traits that distinguish the subset of early stage HPV+ oropharyngeal cancers predisposed to fail standard therapy:oxford.ly/45wkbOu @basulab1 @PennMedicine @Penn_ENT @Penn_CBIO.

JNCI_Now's tweet card. AbstractBackground. Limited understanding of the biology predisposing certain human papillomavirus-related (HPV+) oropharyngeal squamous cell carcinomas (O
Tumor-intrinsic and immune-related features associated with treatment failure in human papillomav...
Source: academic.oup.com
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Wafik S. El-Deiry, MD, PhD, FACP
@weldeiry
Jun 19

I’ve been urged by colleagues to broadcast this loudly @NIHDirector_Jay @RobertKennedyJr 🎤 🇺🇸 📣 📢 ☎️

weldeiry's profile picture. Physician-Scientist Med Onc Pub https://t.co/8RMRruPhfx Director @BrownUCancer Assoc Dean @BrownMedicine @americancancer Prof Chair @WIN_Consortium Boat Capt
Wafik S. El-Deiry, MD, PhD, FACP
@weldeiry
Jun 19

I hope severe budget cuts to @NIH and @theNCI can be avoided to minimize disruption to research progress and a more reasonable budget is passed. Our community needs to plan for US leadership in biomedical research so breakthroughs can help people here and everywhere. @HHSGov

weldeiry's tweet image. I hope severe budget cuts to @NIH and @theNCI can be avoided to minimize disruption to research progress and a more reasonable budget is passed. Our community needs to plan for US leadership in biomedical research so breakthroughs can help people here and everywhere. @HHSGov
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Ravi Uppaluri, MDPhD
 @DrUppaluri
Jun 18

nejm.org/doi/full/10.10…

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Devraj Basu, MD, PhD, FACS reposted
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The ASCO Post
 @ASCOPost
Jun 16

FDA approves pembrolizumab for resectable, locally advanced HNSCC based on KEYNOTE‑689. Led by Dr. Ravindra Uppaluri @DrUppaluri, the study showed a 30% drop in recurrence risk. Full details from The ASCO Post: ascopost.com/news/june-2025… #HNSCC #Oncology

ASCOPost's tweet image. FDA approves pembrolizumab for resectable, locally advanced HNSCC based on KEYNOTE‑689. Led by Dr. Ravindra Uppaluri @DrUppaluri, the study showed a 30% drop in recurrence risk. Full details from The ASCO Post: ascopost.com/news/june-2025… #HNSCC #Oncology
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BasuLab1's profile picture.
Devraj Basu, MD, PhD, FACS
 @BasuLab1
Jun 10

Work with Sagar Kansara, MD, @lucmorrisnyc, @AHNS to help starting to assess how best to apply neoadjuvant + adjuvant anti-PD1 to advanced resectable head and neck cancer in standard clinical practice

AHNSinfo's profile picture. The American Head and Neck Society is the single largest organization in North America for the advancement of research and education in head and neck oncology.
AHNS
 @AHNSinfo
Jun 9

An infographic presented by the AHNS Basic and Translational Science Service The promise and uncertainties of applying the new neoadjuvant anti-PD1 standard created by KEYNOTE-689 #AHNS #neoadjuvant #immunotherapy #HNSCC

AHNSinfo's tweet image. An infographic presented by the AHNS Basic and Translational Science Service The promise and uncertainties of applying the new neoadjuvant anti-PD1 standard created by KEYNOTE-689 #AHNS #neoadjuvant #immunotherapy #HNSCC
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Devraj Basu, MD, PhD, FACS
 @BasuLab1
Jun 5

In case anyone else is also having trouble keeping track...

CJTsaiMDPhD's profile picture. Lead, Allan & Ruth Kerbel Palliative RT/Oligomet Program (PROP) @PMcancercentre @RadMedPM @UHN. Via @MSKCancerCenter @MDAndersonNews. HN/skin/metastatic cancers
C. Jillian Tsai, MD, PhD
 @CJTsaiMDPhD
Jun 5

I'd say ctDNA assays in general. A lot of different assays/variations in sensitivity. I made a very rough table and am going to update it later.

CJTsaiMDPhD's tweet image. I'd say ctDNA assays in general. A lot of different assays/variations in sensitivity. I made a very rough table and am going to update it later.
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Elon Musk

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