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Does cancer #evolution & intra-tumour heterogeneity predict long-term relapse? We tested the evolutionary paradigm in prostate cancer clinical trials with long follow-up, combining genomics with digital histopathology: nature.com/articles/s4301…
New #vacancy for a Lab Manager to support the 11 labs across our Division of Molecular Pathology @ICR_London, which includes our Centre for Evolution and Cancer @CEC_ICR. Details here: jobs.icr.ac.uk/vacancies/961/… @JonesLabICR @kamilkranc @PaedCancerEvol @BezziLab_ICR @HuangLabICR
Starting day 3 of #TMFOCE in sunny #Rimini (admittedly, a bit less “fresh” this morning..) with @GuccioneLab insights on fetal-like phenotypes in CRC 🤩. Perk of Ernesto’s intro, a sneak peak of co-organiser @MagnaniLab_ICR and his past interests (on the left of the pic) 😉🤣
Join one of the world's leading centres for cancer #DrugDiscovery! We're making a significant investment in our Division of #CancerTherapeutics with the appointment of five new senior Faculty. Find out more about the new roles here ⬇ icr.ac.uk/media/docs/def… #ScienceJob
Does immune selection influences tumor antigenicity and impact response to checkpoint inhibitors? Yes! Our latest publication sheds new light on the complex relationship between cancer and the immune system. #immunotherapy #Cancer @ICR_London @CEC_ICR rb.gy/4fqzhm
We see and feel the loss of talented EU students in postgraduate research (including postdocs). The high overseas student fees issue is somewhat mirrored for PhD students too. theguardian.com/education/2023…
theguardian.com
Number of EU students enrolling in UK universities halves post-Brexit
Data shows sharp decline in students from Italy, Germany and France with Brexit seen as primary deterrent
Please RT 🎉🎉🎉 Join us to understand how the ribosome dictates cell identity, focusing on hematopoiesis and leukemia. We're studying cell identity in-vivo and developing new and amazing tools! Fully funded @ERC_Research positions - postdocs and PhDs. nachmanilab.com
nachmanilab.com
Home | The Nachmani Lab
At Daphna Nachmani's lab we study molecular mechanisms controlling hematopoietic stem cell function and hematopoiesis. By focusing on rRNA modifications we aim to reveal translation regulation as a...
(1/8) New Preprint! Would you like to design synthetic cis-regulatory DNA for your preferred application? Look no further! We have made it simple and robust! biorxiv.org/content/10.110…
Cancers are genetic/phenotypic polymorphs, a quasispecies of cellular entities that dances around immune system attacks. We detail an approach to dissect the patchwork behavior of tumors using deep spatial profiling alongside a novel barcoding strategy. sciencedirect.com/science/articl…
Check out our paper just published in @nature showing that melanoma growth and metastatic dissemination are fuelled by limited and distinct cancer cell populations. nature.com/articles/s4158… work led by AMAZING @karraspan (1/3)
Most people at #BCB22 used high-throughput DNA or RNA seq at the centre of their research. But lots of other features define cancer: foremost PROTEINS! Also pH, mechanobiology, oxygen & glucose availability, host factors etc etc. Are we stuck looking under the lamppost? #BCB22_Qs
💥Are you interested in cancer clonal dynamics and resistance to treatments? We have 2 postdoc positions open at the @ICR_London @CEC_ICR to study prostate cancer evolution at single-cell resolution 💥 Apply here jobs.icr.ac.uk/vacancies/335/…
Fantastic study by the lab of our @CR_UK Convergence Science Centre director @behrens_lab and colleagues!
Just out in @Nature! Mesenchymal #PancreaticCancer cells secrete GREM1, preventing further epithelial-to-mesenchymal transition and preserving tumour heterogeneity. Congratulations to postdoc @linxiang_lan et al for the great work! @ICR_London @TheCrick nature.com/articles/s4158…
On behalf of my co-authors I am delighted to share our report published in @CCR_AACR, Assessment of Androgen Receptor splice variant-7 as a biomarker of clinical response in castration-sensitive prostate cancer aacrjournals.org/clincancerres/… @AdamSharpMedOnc 1/10
🚨🚨Last two weeks to apply for a postdoc position in our lab at the @ICR_London @CEC_ICR funded by the @CR_UK 🚨🚨 jobs.icr.ac.uk/vacancies/213/…
What a tour de force! Fantastic and timely analysis of a major prostate cancer subtype.
Kudos to Hyunho, Yan, and our team for having identified Mesenchymal and stem-like prostate cancer (MSPC) and traced its origin to therapy-induced de-differentiation @Columbia @columbiacancer @ColumbiaGenDev @theNCI #metastasis #ProstateCancer #Cancer #in cell.com/cell-reports/f…
How do we infer clonal dynamics in human tissue, when we typically only have access to a single snapshot of that tissue’s evolutionary history? With lineage tracing markers and maths! Our review out now doi.org/10.1002/path.5… @trevoragraham @abobbyandrews
Today is #DarwinDay! 🧬 We spoke to the incoming Director of our Centre for Evolution and #Cancer about his research, how he's inspired by Charles Darwin and the potential of harnessing evolutionary theories to defeat cancer: icr.ac.uk/blogs/science-… #CancerEvolution
Interested in single cell genomics but need help getting started? Check out my lab's Single Cell Genomics Day on March 4. Talks will feature recent exciting computational and experimental advances and will be livestreamed at satijalab.org/scgd. Please RT/spread the word!
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