Chowdhury Lab
@ChowdhuryLab
The Chowdhury lab studies #DSBrepair, #RadiationOncology & #microRNAs as biomarkers @Harvardmed @DanaFarber @BrighamWomens. Account managed by lab members.
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Excited to share our new paper from Sara J. Buhrlage lab & @ChowdhuryLab! We designed CAS-010, a selective, low nanomolar USP28 inhibitor that reduces p53 transcriptional activity, mimics p53 pathway loss & disrupts 53BP1-USP28 binding, offering new insights into USP28 function.
🧬 Grad students and postdocs in DNA repair/DDR: don’t forget to register for the 2026 GRS “Safeguarding the Genome” seminar — Feb 28–Mar 1, Ventura, CA. Keynote: @ChowdhuryLab. Abstracts due by Nov 23, 2025. Register here: 🔗 grc.org/dna-damage-mut…
📢 For all HaloTag lovers💙💚💛❤️💜🩶 we are excited to share that our work, in which we developed a new biotin-HaloTag ligand, is now published in @JCellBiol! Full link here: rupress.org/jcb/article-ab…
Excited to share our publication out in Science today! We define a role for the CST complex in DSB repair pathway choice. This study was conducted in close collaboration with Patrick Sung’s lab. Congratulations to Michelle Swift and all other authors! science.org/doi/10.1126/sc…
Thank you to @ChowdhuryLab (@Harvardmed, @DanaFarber) for joining us for a fantastic #WednedsayLectureSeries on "#DNA repair mechanisms in the context of cell cycle with implication in #cancer." 🧬 Hosted by the Si Lab.
📣 Excited to share our latest review on 53BP1’s function in replication stress, its role in fork protection, and the significance of 53BP1 nuclear bodies in this context! sciencedirect.com/science/articl…
🚨 TENURE-TRACK Faculty Opportunity The Genome Integrity Program @UMassChan umassmed.edu/genomeintegrit… Join us exploring DNA replication/repair with Core services supporting your cutting-edge research. 🔗 Learn more: academicjobsonline.org/ajo/jobs/28037 #Genomics #FacultyJobs #Research #Science
Out in @Nature today! We report that a CDK5-cyclin B1 complex maintains proper cell division. We discovered that CDK5, a long regarded non-cell cycle CDK functioning only in neurons, yet overexpressed in many cancers, does regulate mitosis! Link: nature.com/articles/s4158…
Happy to announce our new publication in @NatureComms, spearheaded by super-talented project leader @ReuterLM . We identified that helicase loading is a self-limiting reaction supporting equal distribution of the replicative helicase across the genome. rdcu.be/dRTAZ
Very grateful that Dana-Farber’s Center for BRCA and Related Genes in collaboration with the @UTHealthSA has been awarded a $3M program project grant from the @theNCI. Honored to lead the research under the new grant with Dr. Panagiotis (Panos) Konstantinopoulos.
📢SAVE THE DATE: 7-10 July 2025 @AgnelSfeir , @KarleneCimprich & @ChowdhuryLab are chairing the #BGFP25 which is taking place in wonderful Lisbon, Portugal next July.☀️ Registration is now OPEN, for more info and details on how to register, follow the 🔗: bit.ly/3AnsVZF
Happy to share a publication from the lab demonstrating that 53BP1 loss is a positive predictive biomarker for immune checkpoint blockade efficacy, with important implications for the treatment of PARPi-resistant ovarian and pancreatic cancers! nature.com/articles/s4146…
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