Churchman Lab
@ChurchmanLab
The Churchman Lab studies transcription elongation and mitochondrial gene expression at Harvard Medical School. Run by @fiddle.
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Blake Tye of @ChurchmanLab gives a beautiful talk about ribosome assembly defects and its role in triggering protein folding stress! @fiddle
Natural RNA Polymerase Aptamers Regulate Transcription in E. coli cell.com/molecular-cell…
A Novel RNA Phosphorylation State Enables 5′ Dependent Degradation in E coli cell.com/molecular-cell…
Heterogeneous Ribosomes Preferentially Translate Distinct Subpools of mRNAs Genome-wide cell.com/molecular-cell…
Single-Cell Alternative Splicing Analysis with Expedition Reveals Splicing Dynamics during Neuron Differentiation cell.com/molecular-cell…
"Cell-cycle dynamics of chromosomal organization at single-cell resolution" From Fraser and Tanay labs. nature.com/nature/journal…
"Recurrent and functional regulatory mutations in breast cancer" Gad Getz lab at the Broad Institute. nature.com/nature/journal…
Transcription elongation factors represent in vivo cancer dependencies in glioblastoma nature.com/nature/journal…
m6A mRNA modifications are deposited in pre-mRNA, are not required for splicing but do specify cytoplasmic turnover genesdev.cshlp.org/content/31/10/…
Organelle-specific RNA mapping by proximity labeling courtesy Alice Ting. biorxiv.org/content/biorxi…
Splicing factor Prp31 mutant flies - the flies are fine in regular light but constant light results in phenotypes biorxiv.org/content/early/…
"Structure of a pre-catalytic spliceosome" Kiyoshi Nagai lab at MRC Laboratory of Molecular Biology. nature.com/nature/journal…
From Nature Reviews "Network propagation: a universal amplifier of genetic associations" (Trey Ideker and others) - nature.com/nrg/journal/va…
From Julia Zeitlinger in Nature Genetics: Paused polymerase II inhibits new transcriptional initiation nature.com/ng/journal/v49…
"Definition of a High-Confidence Mitochondrial Proteome at Quantitative Scale": cell.com/cell-reports/f…
A very nice review on dynamic RNA modifications : cell.com/cell/abstract/…
Non-coding RNAs: the dark side of nuclear– mitochondrial communication (review) emboj.embopress.org/content/36/9/1…
Phase separation drives heterochromatin domain formation from Karpen lab at Berkeley. nature.com/nature/journal…
Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin from Narlikar lab at UCSF. nature.com/nature/journal…
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