Cian McCarthy
@CianPMcCarthy
Cardiologist @MGHHeartHealth | Former IM Resident @MGHMedicine & CV fellow @MGHCVFELLOWS | Alum: @UCC | Irish ☘️ | Opinions are my own
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Is the PREVENT Calculator Best for Determining CVD Risk? Insights From a Post Hoc Analysis of SPRINT Trial medscape.com/viewarticle/pr…
PREVENTing Hypertensive Cardiovascular Disease: Where to Draw the Line? | JACC jacc.org/doi/10.1016/j.…
SHANE LOWRY COMES UP CLUTCH TO RETAIN THE RYDER CUP! #TeamEurope | #OurTimeOurPlace
Mortality in type 1 MI is higher in the short term (<30days post discharge) and lower in the long term (>30 days) ahajournals.org/doi/10.1161/CI… @CianPMcCarthy @CircOutcomes
To win my National Open in front of these fans was absolutely incredible. I love coming home, I love playing in this atmosphere and I’ll never take it for granted. Forever grateful for the support.
assessment and management of patients with type 2 myocardial infarction: an international Delphi study academic.oup.com/ehjqcco/articl…
Rationale and design of the REMBRANDT trial: A phase 3 study to evaluate the effect of #obicetrapib/ezetimibe on coronary plaque characteristics. #LLT sciencedirect.com/science/articl…
AQUATIC In pts with CAD (>6 months after stent) and AF, OAC alone resulted in less major bleeding and less MACE/CV death than OAC and aspirin, with a NNH of 46 patients, contributing to evidence for the OAC alone strategy for chronic CAD and AF nejm.org/doi/full/10.10…
2️⃣ Obicetrapib and Cardiovascular Outcomes x.com/JACCJournals/s… x.com/ProfKausikRay/… BROADWAY NEJM x.com/NEJM/status/19… PREVAIL REBMBRANDT: Obicetrapib+ ezetimibe x.com/CianPMcCarthy/…
Obicetrapib is a selective CETPi which ⏬ LDL-C by ~36%. Now in @AmericanHeartJ, we discuss the rational/design of the phase 3 REMBRANDT trial which will examine the effect of obicetrapib + ezetimibe on coronary plaque. sciencedirect.com/science/articl… @JohnKastelein @ProfSNicholls
DAPA ACT HF TIMI 68 negative trial on inpatient SGLT2i initiation (possibly due to short 2 month follow up and low event rate) but totality of data from EMPULSE, SOLOIST WHF, and DAPA ACT HF TIMI 68 shows significant benefit (incl mortality) to inpatient initiation of SGLT2i 2/4
Conflicting data from REBOOT and BETAMI-DANBLOCK regarding use of beta blockers after MI in preserved LVEF (both published in NEJM), however meta-analysis of trials of mildly reduced LVEF 40-49% shows consistent benefit to beta blockers in this population 4/4
MAPLE-HCM shows Aficamten monotherapy superior to metoprolol monotherapy in symptomatic oHCM patients in improving exercise capacity, symptoms, LVOT gradient, NT proBNP. Could support a paradigm shift to myosin inhibitors as initial therapy for LVOTO? 3/4
BP 139/89 = “normal” BP 140/90 = “disease” Same with cholesterol. These binary thresholds are outdated & misleading jacc.org/doi/10.1016/j.… #JACC #Hypertension #Cholesterol #CVD @johnwmcevoy
In this Viewpoint, @CianPMcCarthy and colleagues advocate for cardiovascular disease outcome trials for new BP lowering treatments targeting novel pathways. ja.ma/4lsA64L @CianPMcCarthy @johnwmcevoy
Implementing the 2025 Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: Leveraging Evidence to Push the Boundaries of Clinical Care | Hypertension ahajournals.org/doi/10.1161/HY…
Blood pressure (BP) guidelines moved the bar lower for hypertension treatment, among other changes in the first national guideline update since 2017. Read more at: medpagetoday.com/cardiology/hyp…
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