Civilization VC
@CivilizationVC
We accelerate (AI) breakthroughs that will define human health + civilization for the next century. Founded by @ShahramSN. RTs/likes ≠ endorsements. 🩺 🧬 AI
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Too many investors rush to “professionalize” companies by replacing emerging CEOs (especially young PhDs) before they’ve had a real opportunity to develop. Others simply don’t have the operating experience to guide founders with depth, and unintentionally push them down the…
Last week was a landmark for our fund and portfolio. Second #IPO of the year! Stock nearly doubled on the first day of trade. Congrats to the entire @BillionToOneInc team!
Hung out with my friend Tyler at the legendary Buck’s restaurant in Woodside. Only in Silicon Valley will you see this type of memorabilia next to the bathroom door!
Never argue with a man in a hoodie who says he’s fixing healthcare with AI. He’s already reached conclusions far beyond your facts.
Making smart investments in #biotech is more than just reviewing patents and papers — that's what most miss. It's the people that make the breakthroughs and overcome challenges. That's the one element that most investors fail to diligence optimally. Know the person.
Humility is a prerequisite to knowledge.
We @tahoe_ai believe models that live up to the title "virtual cell" are a few years away. To build them, we need data. And we need open source, compute-efficient models that make the search for the ultimate models an empirical problem. Our Tahoe-100M dataset was a step towards…
Now that you've read the set up, *here* is the #CEO Oguzhan's incredible story about that fateful day... when we met at a cafe ... and the tides turned for both of us.💸
I received a comment on my Linkedin today from one of the most exceptional #biotech #diagnostics CEOs of our generation - Oguzhan Atay of @BillionToOneInc. In less than a month he will running a public company. A generational company that's changing the lives of #mothers and…
"Surround yourself with data-driven truth-seekers" 💯 The truth shall set you free.
Twenty Years In Early Stage Biotech VC (Part 2): People Continuing in the trifecta of anniversary blogs, here are a few observations on people, talent and teams: · The power of luck! · Life is short… live by the NAR (No Asshole Rule) · By the time you know you need a…
lifescivc.com
Twenty Years In Early Stage Biotech VC (Part 2): People - LifeSciVC
Talented people make the magic happen in biotech. This is the second post in my “Twenty Years In Early Stage Venture” trifecta. Yesterday’s was on Science. Today we’re talking about the People part...
"The single most important value creation activity in biotech is excellent clinical trial execution"
Twenty Years In Early Stage Biotech VC (Part 1) Here are some observations on the “Science” of startups from my vantage point as an early stage VC… · Science-first opportunism beats top-down strategy for deal selection · Don’t believe what you read in science papers at face…
lifescivc.com
Twenty Years In Early Stage Biotech VC (Part 1): Science - LifeSciVC
In the blink of an eye, twenty years have passed: in mid-October 2005, I joined Atlas Venture as a principal on the global life science team. We closed Fund VII a few months after I joined; and,...
Another day, another IPO. We're proud to unveil the pending public offering of @CivilizationVC portfolio company @BillionToOneInc, a diagnostics rocketship. 🚀🧬 We were the first check into the company in 2017 - and I believe the only #lifesciences #healthtech #biotech…
Third - AI will bend healthcare cost curves faster in fields like diagnostics, clinical trial design and healthcare services than therapeutics. Diagnostics is leveraging AI for better liquid biopsy tests, image analysis, multi-omics integration... these are happening now for…
Second: #Biology is nonlinear and more complex than language. When you generate text/video using #AI today, that's thanks to models using tens of trillions of tokens. In contrast, under 20K molecules have been tested in humans to generate the kind of gold standard data we need…
We're seeing daily posts about #bio < > #AI, $1B financings 💰, new models released. But what of it? Are we really about to see a "revolution" in bio fueled by AI? Short answer: soon, but it will take a few more years. Here are my 3 quick thoughts. First - Data, not models,…
#China biotech "curbs" is an important debate, balancing US national security with patient interests. On the one hand, the US should clearly do more to stimulate its domestic #biotech industry through more NIH, NSF and similar funding programs. We should give more incentives for…
This is scary. We're targeting #Parkinson's among other neurodegenerative diseases with our 💵💰💸 at @CivilizationVC.
Once rare, Parkinson's disease is now the fastest growing neurodegenerative disease, with a new case diagnosed every 6 minutes in the US. Why? I argue that it's lax regulation of toxic chemicals, from pesticides to those used in dry cleaning. Read: nytimes.com/2025/09/08/opi…
One of my CEOs asked me this week - "how do I hire"? After starting/running/funding over 70 companies - with 20 exits to players like @Roche @illumina @23andMe - here are my Top 5 Rules. Thread 🧵👇
This is probably one of the most important posts for early stage founders. Especially in biology - when you fail to proactively and precisely point out risks - and instead hype or distort progress - you're fooling no one. And once you lose credibility, it's hard to win it…
Believe it or not, it's usually wise to walk investors through the risks involved in your startup. Investors know there's risk. If there wasn't, your valuation would be billions of dollars right now. And if you're vague about the risks you seem glib, or worse still, clueless.
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