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Dear Chemo, we need to talk… What if therapies used to control primary tumor growth increase the likelihood of metastatic relapse? And how do they impact disseminated cells that have already seeded distant organs at diagnosis? Why do we need to understand EXTRA-TIME....
✨Highlighting a @CD_AACR Special Issue Commentary for #AACR24 - Chemotherapy and the Extra-tumor Immune Microenvironment: EXTRA-TIME - by @LabPhan, Katherine Weilbaecher, Rebecca Aft, Peter Croucher, and @c_chaffer doi.org/10.1158/2159-8… @GarvanInstitute @UNSWScience
1/ How do you recover microenvironmental signals that drive cell differentiation from sc data? By taking the ENTRAIN! ENTRAIN is an environment-aware trajectory inference tool developed by @wunniess a brilliant PhD student @GarvanInstitute @UNSWMedicine. tinyurl.com/2vh2273d
Out today in @JExpMed our @DeenickLab paper comparing APDS1 and APDS2. We show while these two conditions are similar, not all PI3K dysregulation is the same. Great collab with @stutangye and 3 great PhD students @bier_julia, Tina Nguyen and Anthony Lau bit.ly/42rfmlB
In our latest paper, in @SciImmunology, led by @ryangrui from @casanova_lab, we determine the consequences of Tbet deficiency on B cells humoral immunity in humans. science.org/doi/10.1126/sc…
Congrats @ElissaDeenick and @bier_julia from @GarvanInstitute cool review describing a new mechanism of autoantibody production by extrafollicular plasmablasts that bypass GC negative selection in PID patients with PI3K GOF. Relevance to AIHA/ITP? onlinelibrary.wiley.com/doi/10.1111/im…
Another great patient outcome @CIRCA_genomics, @kinghorngenomes and @GarvanInstitute. CTLA4 haploinsufficiency 2˚ to cryptic splicing presenting with Kaposi sarcoma treated with everolimus. Thx to @aifa_news @StVincentClinic @Info4PI and the patients! link.springer.com/article/10.100…
Primary immune deficiency is caused by genetic mutations that lead to immune dysfunction and subsequent susceptibility to infection. @ElissaDeenick @GarvanInstitute et al review the mechanisms underlying defective antibody responses in #PID. #immunology onlinelibrary.wiley.com/doi/10.1111/im…
A summary of @CIRCA_genomics and our blueprint for genomic medicine. Pls see online list of all the amazing CIRCA members. Thanks to @StVincentClinic @aifa_news @Info4PI @GarvanInstitute @kinghorngenomes @IDFAustralia @stutangye et al. For the patients! rdcu.be/b4AX7
First data from the IUIS IEI/PID c'ttee on COVID19 in PID pts are in. thanks to @IsabelleMeyts for summarising • 6 cases reported in PID patients to 22/03, none severe, 3 needing admission. • 1 patient co-infected with another Coronavirus (CoV229E).
This is going to be an incredibly valuable data set for the PID community. So if you’re seeing immune deficient patients affected by #COVID19 please complete this survey prep’d by @katesul23577100 @IsabelleMeyts @MahlaouiNizar
Rare genetic disease diagnosis doesn’t only help patients and their families – it benefits the wider population too. @stutangye and @CIRCA_genomics are delving into DNA to reveal these incredibly uncommon genetic variants medicalresearch.nsw.gov.au/how-rare-disea…
Great talk by @bier_julia from @DeenickLab and @stutangye @GarvanInstitute on APDS syndrome. Using CRISPR mice to dissect the mechanism of immune dysregulation in patients @ASImmunology #ASI2019SA.
Another great Deenick Lab graduate @GarvanInstitute @stutangye
Well done Julia on a fantastic final PhD talk and a great PhD overall. So happy to have you in the @DeenickLab @bier_julia
Fantastic paper by Shane Grey and Chris Goodnow on how A20 tunes immunity. A20 is mutated in some patients with Behcet's which is endemic along the ancient Silk Road. Is the price of immunity a predisposition to autoimmunity? @GarvanInstitute @NatImmunol rdcu.be/bRqcC
Congrats Julia on handing in your thesis! Well done for all you’ve achieved in your PhD. @bier_julia @stutangye
Well done Anthony Lau representing the lab and taking home a prize for his talk on PI3K GOF at the ASI NSW/ACT branch meeting. Fellow Garvinites Gammy and Etienne also taking home prizes. @GarvanInstitute @ASImmunology
Taking a break at the ASI NSW/ACT retreat. Not a bad spot for some Immunology. @ASImmunology
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