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This day in 1812 Spencer Perceval became the only Prime Minister to be assassinated. It's the LEAST interesting thing about him. With his frenemy James Stephen he engineered one of the first bans on slavery in British territory. And he did it WITHOUT parliamentary approval /1 🧵
Delighted to share our newest work on engineering superior effector T states. A new horizon for T cell therapy. Big thanks to Jesus Corria and all the colleagues at Ludwig.
George Coukos and colleagues show that orthogonal cytokine engineering can reprogram CD8 T cells to escape exhaustion leading to tumor regression. Read it here: rdcu.be/daodw @CorriaJesus @CoukosGeorge nature.com/articles/s4159…
HOW TO RELIABLY STOP HICCUPS: Hiccups = phrenic nerve-to-diaphragm spasm. To de-spasm that circuit, inhale maximally (via your nose) 3 times with no exhales in between. Then hold your breath for 15-30 seconds & then slowly exhale (via your mouth). Done.
Like we have observed in the T-synthetic effector cell state induced by orthogonal engineering (doi.org/10.1101/2022.0… ) , Granzyme C also marks a mature cytotoxic effector state of ILC1s, which contribute to antitumor immunity science.org/doi/10.1126/sc… @CoukosGeorge @carmonation
I just had a dream that somehow combined Star Trek, Harry Potter, and Spiderman, and it was EPIC, you're welcome magical Spider-Kirk.
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