Genome Data Science lab
@GenomeDataLab
Computational biology @UCPH_Research/@IRBBarcelona: genetics & evolution of tumors & human populations. #ERC, #HorizonEU, #NNF, #DCS, #DFF funded. PI @FranSupek
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🚨 My PhD paper is officially published in @GenomeBiology! 📜🚀 We quantified the efficiency of a key cellular mRNA QC pathway (NMD) 🧬across thousands of human tumors & healthy tissues, revealing its activity is highly variable! 🧵1/8 👇 🔗genomebiology.biomedcentral.com/articles/10.11…
Fantastic to be in such great company!🤩 👏Congrats to 19 colleagues from my institutions (🇩🇰BRIC @UCPH_health and 🇪🇸@IRBBarcelona) in this year's Elsevier/Stanford top 2% most cited researchers list
Congrats to our CRISPy fresh doctor 👏👏 Marcel McCullough for successfully defending his PhD thesis: 🧬✂️Combinatorial Gene Editing in Human Cells to Model Deficiencies of DNA Repair in Cancer Thx to committee members @CeronLab @LValleResearch and @DSzuts for great discussion!
Very cool collaborative work of our lab w/group of Lluis Ribas at @IRBBarcelona, spearheaded by the 2 Marinas 😀Marina Murillo and our alumna @msalvadoresf
In this fascinating preprint, the authors uncover an eye-opening feature of tRNA genes: they’re insanely prone to mutation. Analyzing somatic mutations in cancer tissues, they report that tRNA genes are up to 9 times more mutated than protein-coding genes. Interestingly, the…
🧵Ahmed’s @GenomeDataLab paper on evolution of chemotherapy resistance is out in @NatureComms! We developed DiffInvex - a method tracking how #cancer driver genes change under therapy, applied to ~10k genomes. Key insight: resistance often emerges through existing pathways. 1/5
🚨 Big news! I'm thrilled to share that our latest research has just been published in Nature Communications 🎉 🔍 Title: DiffInvex identifies evolutionary shifts in driver gene repertoires during tumorigenesis and chemotherapy 📎 doi.org/10.1038/s41467… (1/4) ⬇️
Great news – we received funding from the Independent Research Fund Denmark @DFF_raad! 🧬We will study #cancer driver mutations in tumor suppressor genes. In particular, we will focus on so-called "dominant negative" mutations, by combining #genomics, #AI & CRISPR gene editing
Double PhD defense day in the lab 🤩 Congrats to our dr. Guille Palou @gpaloumarquez, fresh from the oven 🎊🥳 and similarly so our newly-minted dr. Ignasi Toledano @IgnasiToledano! Amazing defense both, bravo 👏👏
Website for the Marie Curie "INTERACT" call for interdisciplinary PhD fellowships at UCph/DTU/DCS is now up 👇 interact-msca.ku.dk Applications open 20th December.
No less than 6⃣6⃣ PhD fellowships will be available to assorted groups at 🌆U of Copenhagen & to 🇩🇰DTU via the "INTERACT" call 🎓Applications open 20/12. Spread the word! Apply + join us👇 Maybe there is a Nobel prize in physics awaiting you as well 😁 linkedin.com/posts/biotech-…
Postdoc and PhD position in AI for cancer genomics at BRIC/UCPH. Only 5 days left to apply!
➡️Postdoc in AI for Cancer Genomics at the Supek Group, BRIC candidate.hr-manager.net/ApplicationIni… ➡️PhD fellowship in AI for Cancer Genomics at the Supek Group, BRIC candidate.hr-manager.net/ApplicationIni… Deadline 14/11. For informal inquiries, drop me an email.
candidate.hr-manager.net
PhD fellowship in AI for Cancer Genomics at the Supek Group, BRIC
PhD fellowship in AI for Cancer Genomics at the Supek Group, BRIC
The youngsters from lab are at @EMBLEvents DNA Replication symposium #EESreplication 🧬 Our alumna dr. Marina @msalvadoresf and PhD Marcell @MarcellVeiner gave talks on their recent work 👏-- identifying DNA replication origins by mutation patterns and neural nets🤖
🔥PhD student & postdoc opportunity @GenomeDataLab! Are you keen on: - driving cutting-edge science @ interface of #AI and cancer #genomics? - working in a dynamic & supportive environment of @UCPH_BRIC? - joining the U of Copenhagen, top-3 ranked uni in EU? Apply below👇
No less than 6⃣6⃣ PhD fellowships will be available to assorted groups at 🌆U of Copenhagen & to 🇩🇰DTU via the "INTERACT" call 🎓Applications open 20/12. Spread the word! Apply + join us👇 Maybe there is a Nobel prize in physics awaiting you as well 😁 linkedin.com/posts/biotech-…
EMBO DNA Replication symposium -> still in time to register to attend! 👏to our @MarcellVeiner and @msalvadoresf - they will have talks on using 🤖#AI and cancer mutation analysis to understand 🧬DNA replication in human cells👇 embl.org/about/info/cou…
Deadline for abstracts approaching! Don't miss this exciting DNA Replication Symposium 🧬 Stellar speaker lineup! MANY talks selected from abstracts.
New pre-print out! 👨🔬 🔗biorxiv.org/content/10.110… Here, we studied the incidence and impact of allele-specific expression (ASE; imbalance between two alleles in mRNA levels ⚖️) in tumorigenesis. 1/6
🤖The @GenomeDataLab develops #ArtificialIntelligence (#AI) models to predict epigenetic disturbances that result from inherited mutations. Their aim is to better predict how heritable and epigenetic changes jointly shape the risk of developing #LungCancer in every individual.
🔢💊Un algoritmo desarrollado por expertos del #IRBBarcelona y del @CRGenomica puede predecir qué fármacos serán más efectivos para el tratamiento de enfermedades genéticas y del #cáncer. 📰@agenciaefe ➡️shorturl.at/7nmVO @GenomeDataLab @BenLehner @IgnasiToledano
2. Early stop codons cause ~10–20% of genetic conditions A promising approach is to force the ribosome to ignore the stop codon, using a drug, to produce full-length proteins How effective this is depends on the drug, the gene, and the stop codon nature.com/articles/s4158…
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