Gitlin Lab MSK
@GitlinLab_MSK
Assistant Member/Professor, Lab Head @MSKCancerCenter ex-@Genentech @StanfordPath @TriIMDPhD. #PhysicianScientist #Immunologist. Views my own.
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Thrilled to share our new paper in @ScienceAdvances 🚀We uncover a new mechanism that protects adipocytes from cell death during #obesity and #ageing — with major implications for metabolic syndrome, including #diabetes, #MASLD and #lipodystrophy. science.org/doi/10.1126/sc…
Our paper is now out in final form at Nature Genetics! For those who missed the preprint, we used large-scale Perturb-seq targeting transcription factors to push primary fibroblasts into diverse transcriptional states, including those observed in cell atlas studies.
I am a strong believer that depth of data can be just as powerful as scale of data. Deep analysis of small groups of humans, and even individuals, can lead to novel biological insights and principles. Today I am the guinea pig. In my own blood, @CalebLareau finds strong evidence…
When I decided to move across the country to do my postdoc with @Satpathology, I knew he was a one-in-a-billion kind of guy. Single-cell sequencing just confirmed it--Check out what the most serendipitous discovery of my career! (PS my mitos are super boring 👎👎)
I am a strong believer that depth of data can be just as powerful as scale of data. Deep analysis of small groups of humans, and even individuals, can lead to novel biological insights and principles. Today I am the guinea pig. In my own blood, @CalebLareau finds strong evidence…
🚨Today, in @NatureCancer, we show that CAR-T cells and CAR-NK cells contain the seeds of their own self-destruction. Disruption of a FAS-L/FAS circuit enhances CAR potency against liquid and solid cancers. rdcu.be/exjEy @MSKCancerCenter @parkerici @MSK_DeptOfMed
Congrats @JustinPerryPhD @MSKCancerCenter !!! 🍾
Out today from @ThePerryLab, our work suggesting how exposure to high fructose in pregnant mice or developing neonates directly affects neurodevelopment. In @Nature nature.com/articles/s4158… @MSKCancerCenter @WeillCornell funded by @NIH @NIH_CommonFund cc: @NIHDirector_Jay
I hereby present the @PershingSqFdn Sohn Prize 2025 Cancer Prize winners.
Please join us in celebrating the 2025 Pershing Square Sohn Cancer Prize winners! This year’s six scientists have been selected for their bold ideas and potential to transform cancer research. The winners are: pershingsquarephilanthropies.org/news/the-persh…
Ovarian cancer takes too many lives and receives too little attention. We’re investing $5.25M in bold, interdisciplinary science to change that. The Pershing Square Ovarian Cancer Challenge Grant is supporting 7 world-class researchers to drive progress where it’s most urgently…
Excited to share our study describing a role for a subset of Thetis cells, TC IV, in tolerance to food antigens. A team effort led by Vanja Cabric and @YollandaPariso1 🧵 1/ science.org/doi/10.1126/sc…
Thank you to @psscra for this amazing support! Will support exciting new work by @joshuakmorrison @WeillCornellGS @MSKCancerCenter exploring TNF and cell death signaling with new genetic tools in vivo.
Please join us in celebrating the 2025 Pershing Square Sohn Cancer Prize winners! This year’s six scientists have been selected for their bold ideas and potential to transform cancer research. The winners are: pershingsquarephilanthropies.org/news/the-persh…
Please join us in celebrating the 2025 Pershing Square Sohn Cancer Prize winners! This year’s six scientists have been selected for their bold ideas and potential to transform cancer research. The winners are: pershingsquarephilanthropies.org/news/the-persh…
Congratulations to Dr. Alexander Gitlin at @MSKCancerCenter. @GitlinLab_MSK is exploring how TNF signaling and Caspase-8 influence colonic inflammation and tumor development, aiming to understand the immune system's role in cancer progression. vimeo.com/1085105928
vimeo.com
Vimeo
Alex Gitlin, MD, PhD - 2025 Pershing Square Sohn Cancer Prize Winner
🔥 congrats to @themis_brown and lab @MSKCancerCenter on this awesome story!! 💥
Yet more brilliance from @themis_brown - its been a joy to have a front-row seat watching her group essentially rewrite the textbook on early life immunity. Kudos to one of the best scientists and human beings that I am fortuate to know! science.org/doi/10.1126/sc…
Combined #preprint and paper alert! Together with @SohrabShah and @VStrongMD, we have been exploring a fundamental paradox of cancer biology: how can the immune response both suppress and facilitate tumorigenesis? (It's a 2-parter!) biorxiv.org/content/10.110…
Excited to share our paper out today in @CellPressNews discovering RNA mis-splicing derived neoantigens & their cognate T cell receptors (TCRs) as well as characterization of endogenous neoantigen T cells in leukemia patients. authors.elsevier.com/sd/article/S00…
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