LabWaggoner's profile picture. Research lab of Dr. Stephen Waggoner. Opinions expressed are Dr. Waggoner's alone and not on behalf of lab staff or employer.
@labwaggoner.bsky.social

Waggoner Lab

@LabWaggoner

Research lab of Dr. Stephen Waggoner. Opinions expressed are Dr. Waggoner's alone and not on behalf of lab staff or employer. @labwaggoner.bsky.social

Optimized arenaviruses with tumor-tropic mutations promote safe anti-tumor efficacy via sustainable immune modulatory properties @CellRepMed cell.com/cell-reports-m… 🇩🇪

LabWaggoner's tweet image. Optimized arenaviruses with tumor-tropic mutations promote safe anti-tumor efficacy via sustainable immune modulatory properties @CellRepMed 
cell.com/cell-reports-m… 🇩🇪

Review @CellRepMed @YvK13 🇳🇱 Dendritic cell immunotherapy advances for solid tumors: Vaccination and modulation cell.com/cell-reports-m…

LabWaggoner's tweet image. Review @CellRepMed @YvK13 🇳🇱
Dendritic cell immunotherapy advances for solid tumors: Vaccination and modulation
cell.com/cell-reports-m…

Conversion of highly specific IgGs into IgM induces broader reactivity toward several human pathogens while preserving functional activity @CellRepMed cell.com/cell-reports-m… 🇳🇱 @UMCU_Intl

LabWaggoner's tweet image. Conversion of highly specific IgGs into IgM induces broader reactivity toward several human pathogens while preserving functional activity @CellRepMed 
cell.com/cell-reports-m… 🇳🇱 @UMCU_Intl

Genetically Engineered Organs for Early Reporting of Transplant Rejection @MolTherapy 🇺🇸🇳🇱 @harvardmed cell.com/molecular-ther…

LabWaggoner's tweet image. Genetically Engineered Organs for Early Reporting of Transplant Rejection @MolTherapy 🇺🇸🇳🇱 @harvardmed 
cell.com/molecular-ther…

Virus driven Disruption of Transcription Termination (DoTT) generated cellular Z-RNAs are bona fide ZBP1 ligands driving cell death as a host response to counter viral disruption of the cellular transcriptional machinery @Nature 🇺🇸🇩🇪 @FoxChaseCancer nature.com/articles/s4158…

LabWaggoner's tweet image. Virus driven Disruption of Transcription Termination (DoTT) generated cellular Z-RNAs are bona fide ZBP1 ligands driving cell death as a host response to counter viral disruption of the cellular transcriptional machinery @Nature 🇺🇸🇩🇪 @FoxChaseCancer
nature.com/articles/s4158…

Chronic HBV infection impairs the glucose metabolism and effector function of NK cells via HBsAg/IL-15/mTOR axis @cddpress @ShandongU 🇨🇳 nature.com/articles/s4141…

LabWaggoner's tweet image. Chronic HBV infection impairs the glucose metabolism and effector function of NK cells via HBsAg/IL-15/mTOR axis @cddpress @ShandongU 🇨🇳
nature.com/articles/s4141…

Cholesterol sensing by the SCAP–FAM134B complex regulates ER-phagy and STING innate immunity @NatureCellBio @ZheJiangUniv 🇨🇳 nature.com/articles/s4155…

LabWaggoner's tweet image. Cholesterol sensing by the SCAP–FAM134B complex regulates ER-phagy and STING innate immunity @NatureCellBio @ZheJiangUniv 🇨🇳
nature.com/articles/s4155…

Mitochondrial anchored protein ligase (MAPL) induces pyroptosis through an inflammatory pathway involving mitochondria and lysosomes @NatureCellBio @mitodynamics @mitocollier @mcgillu 🇨🇦 nature.com/articles/s4155…

LabWaggoner's tweet image. Mitochondrial anchored protein ligase (MAPL) induces pyroptosis through an inflammatory pathway involving mitochondria and lysosomes @NatureCellBio 
@mitodynamics @mitocollier @mcgillu 🇨🇦
nature.com/articles/s4155…

UBE2L3 is a keratinocyte-intrinsic suppressor of epidermal IL-17 production in Vγ2+ γδT cells in mouse and CD8+ T cells in human through the CXCL16/CXCR6 signaling pathway in psoriasis @NatureComms @ZheJiangUniv 🇨🇳 nature.com/articles/s4146…

LabWaggoner's tweet image. UBE2L3 is a keratinocyte-intrinsic suppressor of epidermal IL-17 production in Vγ2+ γδT cells in mouse and CD8+ T cells in human through the CXCL16/CXCR6 signaling pathway in psoriasis @NatureComms  @ZheJiangUniv 🇨🇳
nature.com/articles/s4146…

Lung tissue–resident memory T cells optimize protection by IL-10 regulation of innate immunity @JExpMed @DonnaFarber3 @Columbia 🇺🇸 rupress.org/jem/article/22…

LabWaggoner's tweet image. Lung tissue–resident memory T cells optimize protection by IL-10 regulation of innate immunity @JExpMed @DonnaFarber3 @Columbia 🇺🇸
rupress.org/jem/article/22…

Adenosine metabolic clearance maintains liver homeostasis by licensing arginine methylation of RIPK1 @JExpMed @HuazhongUST 🇨🇳 rupress.org/jem/article/22…

LabWaggoner's tweet image. Adenosine metabolic clearance maintains liver homeostasis by licensing arginine methylation of RIPK1 @JExpMed @HuazhongUST 🇨🇳
rupress.org/jem/article/22…

Waggoner Lab さんがリポスト

So excited to share are wonderful collaboration lead by Weihong @YalePediatrics and Kimberley and Shruti from @TuftsMedicalCtr on in utero SI B cell development from CLPs @YaleIBIO @YaleMed

B cell development may occur earlier in life than previously thought. @LizaKonnikova & team @TuftsMedSchool report on a conserved intestinal B cell niche in mice and humans, challenging traditional models of lymphopoiesis: insight.jci.org/articles/view/… The image: Immunolabeling of…

JCI_insight's tweet image. B cell development may occur earlier in life than previously thought.

@LizaKonnikova & team @TuftsMedSchool report on a conserved intestinal B cell niche in mice and humans, challenging traditional models of lymphopoiesis: insight.jci.org/articles/view/… 

The image: Immunolabeling of…


Waggoner Lab さんがリポスト

Children face double the risk of Long COVID following SARS-CoV-2 reinfection. Results from a large study of >400,000 children showing increased risk of cardiac damage, mental health, and other symptoms. Reducing the number of reinfections is critical

Daniel_E_Park's tweet image. Children face double the risk of Long COVID following SARS-CoV-2 reinfection. Results from a large study of >400,000 children showing increased risk of cardiac damage, mental health, and other symptoms.
Reducing the number of reinfections is critical

Waggoner Lab さんがリポスト

In one human lifetime (~80 years), global average temperature has risen about 1.3–1.4 °C (≈ 2.3–2.5 °F). That’s based on NASA, NOAA, and Berkeley Earth datasets comparing the 1940s to today — the fastest sustained warming in at least 100,000 years.

I would be interested to know how much warming has occurred in “one human lifetime” What data you are basing your figures on please



Inhibitory receptor SIRPα impedes antitumor immunity by binding to CD18 (β2 integrin) in cis on macrophages @SciImmunology @VeilletteAndre @tangzhenghai1 @umacau_ @ircm_mtl @UMontreal 🇨🇦🇨🇳 science.org/doi/10.1126/sc…

LabWaggoner's tweet image. Inhibitory receptor SIRPα impedes antitumor immunity by binding to CD18 (β2 integrin) in cis on macrophages @SciImmunology @VeilletteAndre @tangzhenghai1 @umacau_ @ircm_mtl @UMontreal 🇨🇦🇨🇳
science.org/doi/10.1126/sc…

SARS-CoV-2 variant booster vaccination broadens human B cell responses through the germinal center reaction @SciImmunology @deepikajaiswa18 @SameerMalladi @WashUMedicine @gogo_science @IcahnMountSinai 🇺🇸 science.org/doi/10.1126/sc…

LabWaggoner's tweet image. SARS-CoV-2 variant booster vaccination broadens human B cell responses through the germinal center reaction @SciImmunology @deepikajaiswa18 @SameerMalladi @WashUMedicine @gogo_science @IcahnMountSinai 🇺🇸
science.org/doi/10.1126/sc…

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