HevenerLab
@HevenerLab
Pharmacy Education and Infectious Disease Research at University of Tennessee, College of Pharmacy
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Really enjoyed reading this. "What’s in a Name? Drug Nomenclature and Medicinal Chemistry Trends using INN Publications" pubs.acs.org/doi/10.1021/ac…
Very nice summary. Interesting how many of these were biologics. nature.com/articles/d4157…
Congrats to Dr. Dianqing Sun on his lab's latest publication! We were excited to assist with some of the modeling on this manuscript discussing novel anti-staphylococcal compounds. pubs.acs.org/doi/10.1021/ac…
pubs.acs.org
Pharmacophore Modeling, Synthesis, and Antibacterial Evaluation of Chalcones and Derivatives
A series of novel chalcone and thiol-Michael addition analogues was synthesized and tested against Mycobacterium tuberculosis and other clinically significant bacterial pathogens. Previously reported...
Check out our team's publication on the essentiality of the FabK enzyme in C. difficile! Congrats to Dr. Hurdle and his folks at Texas A&M. pubs.acs.org/doi/10.1021/ac…
pubs.acs.org
The Fatty Acid Synthesis Protein Enoyl-ACP Reductase II (FabK) is a Target for Narrow-Spectrum...
Clostridium difficile infection (CDI) is an antibiotic-induced microbiota shift disease of the large bowel. While there is a need for narrow-spectrum CDI antibiotics, it is unclear which cellular...
Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysis thelancet.com/journals/lanin…
Check out the lab's latest manuscript that just hit press, a review in a recent Methods in Enzymology text. sciencedirect.com/science/articl…
Good review article on Drug Repurposing in NRDD. nature.com/articles/nrd.2…
Clearance in Drug Design pubs.acs.org/doi/10.1021/ac…
pubs.acs.org
Clearance in Drug Design
Due to its implications for both dose level and frequency, clearance rate is one of the most important pharmacokinetic parameters to consider in the design of drug candidates. Clearance can be...
This bacteria is engineered to be a probiotic that expresses the human protein that is mutated in people with phenylketonuria. Pretty cool. nature.com/articles/nbt.4…
nature.com
Development of a synthetic live bacterial therapeutic for the human metabolic disease phenylketon...
Nature Biotechnology - Synthetic probiotic for a human metabolic disease is taken through a drug development pathway to enable translation into clinic trials.
Shared Platform for Antibiotic Research and Knowledge: A Collaborative Tool to SPARK Antibiotic Discovery pubs.acs.org/doi/10.1021/ac…
pubs.acs.org
Shared Platform for Antibiotic Research and Knowledge: A Collaborative Tool to SPARK Antibiotic...
The discovery of urgently needed antibiotics is hindered by challenges to information sharing. To help address this challenge, The Pew Charitable Trusts launched SPARK: the Shared Platform for...
I always find the comments section of these posts so informative. blogs.sciencemag.org/pipeline/archi…
They used to say kinases were 'undruggable' now there's several kinase inhibitors on the market. Now phosphatase inhibitors could be possible? Perhaps we should reconsider our use of the term 'undruggable'. drugdiscoverytoday.com/view/47513/new…
Please Retweet: Postdoctoral Research Associate : Houston, TX, United States : Naturejobs - nature.com/naturejobs/sci… - via @naturejobs
Reached a milestone: first paper to hit 100 citations! Published as a graduate student in the Lee lab. This paper took off in the last couple years for some reason. pubs.acs.org/doi/full/10.10…
pubs.acs.org
Validation of Molecular Docking Programs for Virtual Screening against Dihydropteroate Synthase
Dihydropteroate synthase (DHPS) is the target of the sulfonamide class of antibiotics and has been a validated antibacterial drug target for nearly 70 years. The sulfonamides target the p-aminobenz...
The latest publication from the Hevener laboratory just hit press, a review article discussing topoisomerase-targeted cancer chemotherapy. Special thanks to the UTHSC pharmacy students who worked... sciencedirect.com/science/articl…
New UTHSC Tennessee Clinical and Translational Science Institute Established to Improve Human Health for Southerners. news.uthsc.edu/new-uthsc-tenn…
The latest publication from the Hevener lab just hit press - a chapter in Methods in Molecular Biology - Computational Toxicology. 🍻 link.springer.com/protocol/10.10…
Study Shows Sulfonamide Antibacterials Capable of Reversing Azole Resistance in Candida albicans shar.es/anFwVN
Learning about an emerging fungal pathogen, Candida auris at #ASMicrobe scary stuff
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