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Hyungsoon Im

@ImLabMGH

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Hyungsoon Im reposted

New perspective in @NatureRevCancer Defining precancer: a grand challenge for the cancer community nature.com/articles/s4156… From @theNCI Precancer Think Tank Team, we hope the article provides researchers with a framework to start addressing key topics in preneoplasia research.

Aiims1742's tweet image. New perspective in @NatureRevCancer 
Defining precancer: a grand challenge for the cancer community
nature.com/articles/s4156…
From @theNCI Precancer Think Tank Team, we hope the article provides researchers with a framework to start addressing key topics in preneoplasia research.

Hyungsoon Im reposted

What happens to an ADC after its infusion? How does it interact with tumor & immune cells, what causes response & resistance? Take a deep dive in the molecular world of ADCs though our last review, led by @AlfredZippelius and published in @NatureRevCancer. nature.com/articles/s4156…

PTarantinoMD's tweet image. What happens to an ADC after its infusion? How does it interact with tumor & immune cells, what causes response & resistance? Take a deep dive in the molecular world of ADCs though our last review, led by @AlfredZippelius and published in @NatureRevCancer. nature.com/articles/s4156…

Hyungsoon Im reposted

ctDNA analysis of SONIA published on @NatureMedicine. 34% of the patients had high ctDNA before entering the study, and derived a PFS2 benefit from an early (first line) use of CDK4/6-inhibitors. Patients with low ctDNA, instead, derived no benefit. nature.com/articles/s4159…

PTarantinoMD's tweet image. ctDNA analysis of SONIA published on @NatureMedicine. 34% of the patients had high ctDNA before entering the study, and derived a PFS2 benefit from an early (first line) use of CDK4/6-inhibitors. Patients with low ctDNA, instead, derived no benefit. nature.com/articles/s4159…

Hyungsoon Im reposted

🧵 CRP vs Procalcitonin – Inflammation vs Infection? Both rise in systemic illness. But they don’t speak the same language. Let’s break down when to use CRP, when to trust Procalcitonin—and when both lie. 👇 @IhabFathiSulima @DrAkhilX @Janetbirdope @emcrit @andrewsuleh

Rheumat_Aravind's tweet image. 🧵 CRP vs Procalcitonin – Inflammation vs Infection?

Both rise in systemic illness.
But they don’t speak the same language.

Let’s break down when to use CRP, when to trust Procalcitonin—and when both lie. 👇
@IhabFathiSulima @DrAkhilX @Janetbirdope @emcrit @andrewsuleh…

Hyungsoon Im reposted

Excellent review in @NatRevClinOncol📣🌟 An integrated algorithm for Cancer of Unknown Primary diagnosis & treatment combines histologic morphology, IHC, gene expression profiling & genomic sequencing, establishing a new therapeutic paradigm. doi.org/10.1038/s41571… @OncoAlert

OscarTahuahua's tweet image. Excellent review in @NatRevClinOncol📣🌟

An integrated algorithm for Cancer of Unknown Primary diagnosis & treatment combines histologic morphology, IHC, gene expression profiling & genomic sequencing, establishing a new therapeutic paradigm.

doi.org/10.1038/s41571… @OncoAlert

Hyungsoon Im reposted

Multiple ADCs have outperformed chemo for treating mBC. Yet their most transformative impact is expected in the curative setting. DB11 will report at #ESMO25 & much more is coming. We review the field in our latest NPJ Breast review, led by Pooja Patel. nature.com/articles/s4152…

PTarantinoMD's tweet image. Multiple ADCs have outperformed chemo for treating mBC. Yet their most transformative impact is expected in the curative setting. DB11 will report at #ESMO25 & much more is coming. We review the field in our latest NPJ Breast review, led by Pooja Patel. nature.com/articles/s4152…

Hyungsoon Im reposted

Cancer vaccines will be a big part of the future of immunotherapy. A new, super review @TheLancet thelancet.com/journals/lance…

EricTopol's tweet image. Cancer vaccines will be a big part of the future of immunotherapy. A new, super review @TheLancet 
thelancet.com/journals/lance…

Hyungsoon Im reposted

A new cell line atlas of biliary tract cancers uncovers new subtypes and potential drug targets for better treatment of these deadly diseases. Learn more: broad.io/DepMap-BTCs @MGBResearchNews @targetcancer

broadinstitute's tweet image. A new cell line atlas of biliary tract cancers uncovers new subtypes and potential drug targets for better treatment of these deadly diseases. Learn more: broad.io/DepMap-BTCs 

@MGBResearchNews @targetcancer

Hyungsoon Im reposted

The ultimate ADC review! 40 years of ADC. Must read for residents. 10.1158/2159-8290.CD-24-0708 @tuttsakhil @drvineetgovinda @shaunak_3 @SuyogCancer @todrashish @jtgeorgy @ajoyojohn

medoncodoc's tweet image. The ultimate ADC review! 40 years of ADC. Must read for residents. 

10.1158/2159-8290.CD-24-0708

@tuttsakhil @drvineetgovinda @shaunak_3 @SuyogCancer @todrashish @jtgeorgy @ajoyojohn
medoncodoc's tweet image. The ultimate ADC review! 40 years of ADC. Must read for residents. 

10.1158/2159-8290.CD-24-0708

@tuttsakhil @drvineetgovinda @shaunak_3 @SuyogCancer @todrashish @jtgeorgy @ajoyojohn
medoncodoc's tweet image. The ultimate ADC review! 40 years of ADC. Must read for residents. 

10.1158/2159-8290.CD-24-0708

@tuttsakhil @drvineetgovinda @shaunak_3 @SuyogCancer @todrashish @jtgeorgy @ajoyojohn
medoncodoc's tweet image. The ultimate ADC review! 40 years of ADC. Must read for residents. 

10.1158/2159-8290.CD-24-0708

@tuttsakhil @drvineetgovinda @shaunak_3 @SuyogCancer @todrashish @jtgeorgy @ajoyojohn

Hyungsoon Im reposted

🎯 ADC success rate & time in Phase: ~10% of phase 1 ADCs makes it to approval (three times higher than other drug classes) Recent ADCs took a median time of 7 years from clinical introduction to approval. Shortest time for T-DXd (only 4 years!) Via Lavinia Woodward (#Beacon)

PTarantinoMD's tweet image. 🎯 ADC success rate & time in Phase:

~10% of phase 1 ADCs makes it to approval (three times higher than other drug classes)

Recent ADCs took a median time of 7 years from clinical introduction to approval.

Shortest time for T-DXd (only 4 years!)

Via Lavinia Woodward (#Beacon)

Hyungsoon Im reposted

12 lessons students learn in the Sinclair Lab: Lesson 1. Write the way you speak

davidasinclair's tweet image. 12 lessons students learn in the Sinclair Lab:
 
Lesson 1. Write the way you speak

Hyungsoon Im reposted

Online now: Strategies for mitigating data heterogeneities in AI-based neuro-disease detection dlvr.it/TJJC9F

NeuroCellPress's tweet image. Online now:  Strategies for mitigating data heterogeneities in AI-based neuro-disease detection dlvr.it/TJJC9F

When AI models are developed based on clinical data, many issues with data heterogeneity are often overlooked. In this NeuroView article published in Neuron, we shared our strategies for mitigating these underlying issues in developing neuro-AI models. dlvr.it/TJJC9F


Hyungsoon Im reposted

How can AI overcome data challenges when detecting neurological diseases?@NeuroCellPress @MGHCSB "Strategies for mitigating data heterogeneities in AI-based neuro-disease detection" • This NeuroView article discusses strategies for mitigating data heterogeneities in AI-based…

aipulserx's tweet image. How can AI overcome data challenges when detecting neurological diseases?@NeuroCellPress @MGHCSB 

"Strategies for mitigating data heterogeneities in AI-based neuro-disease detection"

• This NeuroView article discusses strategies for mitigating data heterogeneities in AI-based…

Hyungsoon Im reposted

Analyzing a big stack of images from #Microscopy 🔬? Check out our CycloNET pipeline to ease your workload. The paper is officially out 🎉. The code is open for everyone to access on the @MGHCSB site (csb.mgh.harvard.edu/bme_software). doi.org/10.1038/s41598…

HakhoLee_Lab's tweet image. Analyzing a big stack of images from #Microscopy 🔬? Check out our CycloNET pipeline to ease your workload. The paper is officially out 🎉. The code is open for everyone to access on the @MGHCSB site (csb.mgh.harvard.edu/bme_software).  

doi.org/10.1038/s41598…

Hyungsoon Im reposted

Happy to share our new paper on SCOPE technology! 🎉 This innovative CRISPR assay recognizes and amplifies target mRNA with incredible precision, enabling the detection of low-abundant mRNA in #extracellularvesicles. go.nature.com/47Yw8Mf.

HakhoLee_Lab's tweet image. Happy to share our new paper on SCOPE technology! 🎉  This innovative CRISPR assay recognizes and amplifies target mRNA with incredible precision, enabling the detection of low-abundant mRNA in #extracellularvesicles. go.nature.com/47Yw8Mf.

Hyungsoon Im reposted

Thrilled to welcome our collaborators from @MbararaUST and @KNUSTKH to @MGHCSB 🎉. We are working together to implement a point-of-care test for #cervicalcancer, backed by the @theNCI Affordable Cancer Technologies initiative. Their local #HPV work is truly inspiring!

HakhoLee_Lab's tweet image. Thrilled to welcome our collaborators from @MbararaUST and @KNUSTKH to @MGHCSB 🎉. We are working together to implement a point-of-care test for #cervicalcancer, backed by the @theNCI Affordable Cancer Technologies initiative. Their local #HPV work is truly inspiring!

Hyungsoon Im reposted

For readers interested in antibody-drug conjugates as cancer therapies, here's a comprehensive review nature.com/articles/s4157… rdcu.be/dROhz

NatRevDrugDisc's tweet image. For readers interested in antibody-drug conjugates as cancer therapies, here's a comprehensive review nature.com/articles/s4157… rdcu.be/dROhz

Hyungsoon Im reposted

How to map your research article efficiently

acagamic's tweet image. How to map your research article efficiently

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