Hyungsoon Im
@ImLabMGH
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New perspective in @NatureRevCancer Defining precancer: a grand challenge for the cancer community nature.com/articles/s4156… From @theNCI Precancer Think Tank Team, we hope the article provides researchers with a framework to start addressing key topics in preneoplasia research.
What happens to an ADC after its infusion? How does it interact with tumor & immune cells, what causes response & resistance? Take a deep dive in the molecular world of ADCs though our last review, led by @AlfredZippelius and published in @NatureRevCancer. nature.com/articles/s4156…
ctDNA analysis of SONIA published on @NatureMedicine. 34% of the patients had high ctDNA before entering the study, and derived a PFS2 benefit from an early (first line) use of CDK4/6-inhibitors. Patients with low ctDNA, instead, derived no benefit. nature.com/articles/s4159…
🧵 CRP vs Procalcitonin – Inflammation vs Infection? Both rise in systemic illness. But they don’t speak the same language. Let’s break down when to use CRP, when to trust Procalcitonin—and when both lie. 👇 @IhabFathiSulima @DrAkhilX @Janetbirdope @emcrit @andrewsuleh…
Excellent review in @NatRevClinOncol📣🌟 An integrated algorithm for Cancer of Unknown Primary diagnosis & treatment combines histologic morphology, IHC, gene expression profiling & genomic sequencing, establishing a new therapeutic paradigm. doi.org/10.1038/s41571… @OncoAlert
Multiple ADCs have outperformed chemo for treating mBC. Yet their most transformative impact is expected in the curative setting. DB11 will report at #ESMO25 & much more is coming. We review the field in our latest NPJ Breast review, led by Pooja Patel. nature.com/articles/s4152…
Cancer vaccines will be a big part of the future of immunotherapy. A new, super review @TheLancet thelancet.com/journals/lance…
A new cell line atlas of biliary tract cancers uncovers new subtypes and potential drug targets for better treatment of these deadly diseases. Learn more: broad.io/DepMap-BTCs @MGBResearchNews @targetcancer
The ultimate ADC review! 40 years of ADC. Must read for residents. 10.1158/2159-8290.CD-24-0708 @tuttsakhil @drvineetgovinda @shaunak_3 @SuyogCancer @todrashish @jtgeorgy @ajoyojohn
Happy to share our new review article on the sensing and imaging of #ExtracellularVesicles. Published with @SpringerNature in @LightSciAppl. @MGHCSB @MGBResearchNews nature.com/articles/s4137…
🎯 ADC success rate & time in Phase: ~10% of phase 1 ADCs makes it to approval (three times higher than other drug classes) Recent ADCs took a median time of 7 years from clinical introduction to approval. Shortest time for T-DXd (only 4 years!) Via Lavinia Woodward (#Beacon)
12 lessons students learn in the Sinclair Lab: Lesson 1. Write the way you speak
Online now: Strategies for mitigating data heterogeneities in AI-based neuro-disease detection dlvr.it/TJJC9F
When AI models are developed based on clinical data, many issues with data heterogeneity are often overlooked. In this NeuroView article published in Neuron, we shared our strategies for mitigating these underlying issues in developing neuro-AI models. dlvr.it/TJJC9F
How can AI overcome data challenges when detecting neurological diseases?@NeuroCellPress @MGHCSB "Strategies for mitigating data heterogeneities in AI-based neuro-disease detection" • This NeuroView article discusses strategies for mitigating data heterogeneities in AI-based…
Analyzing a big stack of images from #Microscopy 🔬? Check out our CycloNET pipeline to ease your workload. The paper is officially out 🎉. The code is open for everyone to access on the @MGHCSB site (csb.mgh.harvard.edu/bme_software). doi.org/10.1038/s41598…
Happy to share our new paper on SCOPE technology! 🎉 This innovative CRISPR assay recognizes and amplifies target mRNA with incredible precision, enabling the detection of low-abundant mRNA in #extracellularvesicles. go.nature.com/47Yw8Mf.
Thrilled to welcome our collaborators from @MbararaUST and @KNUSTKH to @MGHCSB 🎉. We are working together to implement a point-of-care test for #cervicalcancer, backed by the @theNCI Affordable Cancer Technologies initiative. Their local #HPV work is truly inspiring!
For readers interested in antibody-drug conjugates as cancer therapies, here's a comprehensive review nature.com/articles/s4157… rdcu.be/dROhz
How to map your research article efficiently
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