Åsa Hidmark
@ImmRes
Immunology Research Consultant. PhD at Karolinska, 7 years at Heidelberg University. Swedish, English, German, French
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A new anti-cancer approach involves an antibody that blocks two key proteins needed by tumors to build blood vessels buff.ly/2piUoCY
How bad science has misled millions with chronic fatigue syndrome | OPINION bit.ly/2ofQ0Ti
"Vaccines have been so successful that we’ve lost the historical memory of the impact these diseases have on children." – @FlaviaBustreo
Also, gene-environment interactions may be underestimated if gene-gene interactions are not taken into account
Swedish scientists described 2015 how genes interact with the environment to modify susceptibility to environment ncbi.nlm.nih.gov/pmc/articles/P…
This and other similar published works indicates that specific gene combinations heighten susceptibility
>the high activity MAOA allele promotes aggression in boys which had been experiencing child abuse and also had the 5-HTTLPR “SS” genotype
Two genes involved in serotonin signalling, monoamine oxidase A gene (breaking down serotonin) and 5-HTT (transporting seretonin) >
This study shows that the interaction between 2 alleles promotes aggression in a specific environment ncbi.nlm.nih.gov/pmc/articles/P…
>of genes is much lower. In particular if your mate has a different genetic setup, then the heritability of combinations is lower
Implications for heritability of a genetic trait: While the Mendelian chance to inherit one gene is 50%, the chance to inherit combination >
Certain alleles are only associate with the phenotype in a very specific setting of other genes, which are also conditionally associated
This is an important principle explanation for why large genome wide association investigations doesn't come up with individual candidates
This means that the risk for schizofrenia is increased when there is a specific combination of genes rather than these alleles by themselves
Epistasisc effect (gene-dene-interaction) is shown for 2 genes where different alleles affect risk for schizophrenia sciencedirect.com/science/articl…
Chinese scientist modify human embryos using CRISPR/Cas9 with up to 80% successrate
Des chercheurs modifient des embryons humains viables en utilisant CRISPR/Cas9 sciencesetavenir.fr/sante/des-cher…
The bad luck is not only mutants arising: it is our immune system failing to deal with them.
66 percent of cancer-causing genetic mutations arise from the “bad luck” bit.ly/2opdZ3I
Encouraging! Strong results for low-cost, heat-stable #rotavirus vaccine in #Niger 🇳🇪 ow.ly/anGC30ab2nH v/@NEJM #vaccineswork
And also “We know lack of access to healthy food is associated with bad outcomes in virtually every area you look.”
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